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Therapeutic Potential of Peptides in Cancer Treatment: Focus on Peptide and Aptamer-Decorated Exosomes. [PDF]

Cancers (Basel)
Gangadaran P, Kumar AS, Kumaran K, Prakash K, Dhayalan S, Rajendran RL, Loganathbabu VKT, Balaji J, Baskaran R, Arun R, Karthikeyan V, Biswas S, Hong CM, ArulJothi KN, Ahn BC.   +14 more
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LHRH-receptors and LHRH-agonist treatment in ovarian cancer: An overview

The Journal of Steroid Biochemistry and Molecular Biology, 1990
Considerable evidence exists that ovarian cancer might be gonadotrophin-dependent. Receptors for LH and FSH have been discovered in these tumors. Proliferation of ovarian cancer cells in vitro could be stimulated by gonadotrophins. Withdrawal of LH and FSH in animal models of ovarian cancer inhibited growth of these tumors.
G, Emons, G S, Pahwa, O, Ortmann, R, Knuppen, F, Oberheuser, K D, Schulz   +5 more
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Glucocorticoid Receptors in LHRH Neurons

Neuroendocrinology, 2008
Luteinizing hormone-releasing hormone (LHRH)-producing neurons constitute the final pathway for regulation of reproductive endocrine function by the central nervous system. Chronically elevated levels of glucocorticoids exert an inhibitory effect on reproductive function.
R S, Ahima, R E, Harlan
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Effect of LHRH-PE40 on target cells via LHRH receptors

Journal of Drug Targeting, 2008
To detect the effect and cytotoxicity of luteinizing hormone-releasing hormone-Pseudomonas aeruginosa exotoxin 40 (LHRH-PE40) on target cells using LHRH receptors (LHRHR).The affinity of LHRH-PE40 and LHRH binding to LHRHR on the membrane surface of target cells were measured by enzyme linked immunosorbent assay.
Xin, Deng, Sven, Klussmann, Guang-Mou, Wu, Doreen, Akkerman, Ya-Qin, Zhu, Ying, Liu, Hang, Chen, Ping, Zhu, Bing-Zhi, Yu, Guo-Li, Zhang   +9 more
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LHRH RECEPTORS AND LHRH RECEPTOR-BEARING CELLS IN PITUITARIES OF STREPTOZOCIN DIABETIC MALE RATS

Pharmacological Research, 1997
Streptozocin (STZ)-diabetic rats have low hypothalamic luteotropic hormone-releasing hormone (LHRH) secretion and various alterations of gonadotrope cells, among which low luteotropic hormone (LH) secretion. Possible causes for the gonadotrope disorders may be low hypothalamic LHRH secretion alone or combined with reduced (a) number of LHRH receptor ...
Bestetti GE, Barone D, Walz A, Moser B, Boujon CE, Brändli-Baiocco A, Rossi GL   +6 more
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Inhibin Interaction with LHRH Receptors at the Pituitary Level

Archives of Andrology, 1982
In order to investigate whether inhibin could modulate the action of luteinizing hormone releasing hormone (LHRH), the in vitro effect of inhibin of LHRH bindings to the pituitaries from intact adult male rats was studied. The inhibin preparations suppressed the binding of labeled LHRH to pituitary receptors in a dose-related manner.
P R, Sheth, S P, Dandekar, N, Seethalakshmi, A R, Sheth   +3 more
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Absence of androgen receptors in LHRH immunoreactive neurons

Brain Research, 1993
Androgen has a negative feedback effect upon reproductive functions. Studies have suggested that this effect is mediated partially at the hypothalamic level. However, it is not clear whether the action is direct or indirect on LHRH neurons. In the present study, double immunocytochemistry was used to localize LHRH and androgen receptors.
X, Huang, R E, Harlan
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Variations in the number of pituitary LHRH receptors correlated with altered responsiveness to LHRH

Life Sciences, 1982
Isolated pituitary cells from metestrous, ovariectomized (OVX), and ovariectomized-estradiol treated (OVX-EB) rats were employed to study the gonadotrophin response to luteinizing hormone-releasing hormone (LHRH) challenge and to quantitate LHRH receptors, using a labeled LHRH analog.
R, Meidan, N B, Aroya, Y, Koch
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HIGH INCIDENCE OF RECEPTORS FOR LUTEINIZING HORMONE-RELEASING HORMONE (LHRH) AND LHRH RECEPTOR GENE EXPRESSION IN HUMAN PROSTATE CANCERS

Journal of Urology, 2000
Agonistic analogs of luteinizing hormone-releasing hormone (LHRH) are widely used for therapy of advanced prostate cancer based upon their ability to suppress testosterone secretion in patients. Various studies also indicate that LHRH analogs might have direct inhibitory effects on prostate tumors mediated by specific LHRH receptors.
G, Halmos, J M, Arencibia, A V, Schally, R, Davis, D G, Bostwick   +4 more
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Characterization and autoradiographic localization of LHRH receptors in the rat brain

Synapse, 1987
AbstractLuteinizing hormone‐releasing hormone (LHRH) is distributed in several extrahypothalamic areas, suggesting that it might act as a neurotransmitter or neuromodulator in the central nervous system. This study was undertaken to characterize and localize LHRH receptors in the rat brain by using slide‐mounted frozen sections.
M, Badr, G, Pelletier
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