Results 141 to 150 of about 8,865 (194)

Absence of androgen receptors in LHRH immunoreactive neurons

Brain Research, 1993
Androgen has a negative feedback effect upon reproductive functions. Studies have suggested that this effect is mediated partially at the hypothalamic level. However, it is not clear whether the action is direct or indirect on LHRH neurons. In the present study, double immunocytochemistry was used to localize LHRH and androgen receptors.
X, Huang, R E, Harlan
openaire   +2 more sources

Variations in the number of pituitary LHRH receptors correlated with altered responsiveness to LHRH

Life Sciences, 1982
Isolated pituitary cells from metestrous, ovariectomized (OVX), and ovariectomized-estradiol treated (OVX-EB) rats were employed to study the gonadotrophin response to luteinizing hormone-releasing hormone (LHRH) challenge and to quantitate LHRH receptors, using a labeled LHRH analog.
R, Meidan, N B, Aroya, Y, Koch
openaire   +2 more sources

HIGH INCIDENCE OF RECEPTORS FOR LUTEINIZING HORMONE-RELEASING HORMONE (LHRH) AND LHRH RECEPTOR GENE EXPRESSION IN HUMAN PROSTATE CANCERS

Journal of Urology, 2000
Agonistic analogs of luteinizing hormone-releasing hormone (LHRH) are widely used for therapy of advanced prostate cancer based upon their ability to suppress testosterone secretion in patients. Various studies also indicate that LHRH analogs might have direct inhibitory effects on prostate tumors mediated by specific LHRH receptors.
G, Halmos, J M, Arencibia, A V, Schally, R, Davis, D G, Bostwick   +4 more
openaire   +2 more sources

Characterization and autoradiographic localization of LHRH receptors in the rat brain

Synapse, 1987
AbstractLuteinizing hormone‐releasing hormone (LHRH) is distributed in several extrahypothalamic areas, suggesting that it might act as a neurotransmitter or neuromodulator in the central nervous system. This study was undertaken to characterize and localize LHRH receptors in the rat brain by using slide‐mounted frozen sections.
M, Badr, G, Pelletier
openaire   +2 more sources

LHRH Receptor Targeted Therapy for Breast Cancer

2008
Breast cancer remains the most common cancer among women, with an estimated 212,920 new cases and 40,970 deaths in the United States in 2006. The present work extends the studies of nanoparticles targeted to the luteinizing hormone-releasing hormone (LHRH) receptor which is overexpressed in breast, ovarian, endometrial and prostate cancer cells.
S S, Kakar, H, Jin, B, Hong, J W, Eaton, Kyung A, Kang   +4 more
openaire   +2 more sources

Modulation of hippocampal LHRH receptors by sex steroids in the rat

Peptides, 1988
The modulation of brain LHRH receptors by sex steroids was assessed in the female rat hippocampus using in vitro autoradiography and iodinated [D-Ser (TBU)6, des-Gly-NH2(10)]LHRH ethylamide as the radioligand. As evaluated by optical densitometry, the density of hippocampal LHRH receptors was increased by castration.
Badr M, MARCHETTI, Bianca Maria, Pelletier G.   +2 more
openaire   +3 more sources

Targeting of Peptide Cytotoxins to LHRH Receptors For Treatment of Cancer

Current Drug Targets, 2016
Receptors for LHRH (luteinizing hormone-releasing hormone) are expressed in about 80% of human endometrial, ovarian and prostate cancers and are also found in more than 50% of breast cancers including triple negative breast cancers. In the human body, LHRH receptors are found at significant levels in the pituitary and reproductive organs.
Jorg B, Engel, Hans-Rudolf, Tinneberg, Ferenc G, Rick, Enniko, Berkes, Andrew V, Schally   +4 more
openaire   +2 more sources

LHRH receptor expression in sarcomas of bone and soft tissue

Hormone Molecular Biology and Clinical Investigation, 2016
Abstract Aim: Luteinizing hormone releasing hormone (LHRH) is a neurohormone, secreted by the hypothalamus, which regulates the secretion of gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary.
Chenthuran, Deivaraju, H Thomas, Temple, Norman, Block, Philip, Robinson, Andrew V, Schally   +4 more
openaire   +2 more sources

Receptor-mediated internalization of LHRH antagonists by pituitary cells

Molecular and Cellular Endocrinology, 1983
A fluorescently labeled antagonist of luteinizing hormone releasing hormone (LHRH), D-pGlu-D-Phe-D-Trp-Ser-Tyr-D-Lys6-(tetramethylrhodamine)-Leu-Arg-Pro-Gly-NH2, was prepared. This peptide retained high-affinity binding to the LHRH receptor of pituitary plasma membrane preparations.
E, Hazum, R, Meidan, M, Liscovitch, D, Keinan, H R, Lindner, Y, Koch   +5 more
openaire   +2 more sources

Effects of an LHRH agonist and gonadotropins on testicular prolactin receptors

Peptides, 1982
Effects of administration of the LHRH agonist D-Leu6-LHRH ethylamide (LHRH-A), gonadotropin (PMS), and their interaction on testicular prolactin (PRL) receptor levels were investigated in rats. LHRH-A (2 micrograms/100 g body wt.) or saline was injected SC daily, and PMS (5 IU) injected every other day.
J B, Fishback, A, Arimura, C M, Turkelson   +2 more
openaire   +2 more sources