Results 251 to 260 of about 2,728,981 (353)

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

Melatonin ameliorates TNFα-induced oral epithelial cell inflammation via Keap1-Nrf2 axis modulation. [PDF]

Am J Transl Res
Wang S, Wang W, Zhang R, Liu Y, Wang Y, Bai Y, Bai Y.   +6 more
europepmc   +1 more source

Characterizing circadian rest–activity rhythm patterns across Alzheimer's disease continuum in Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Sleep and circadian rest–activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR patterns across the DS‐associated AD continuum remain uncharacterized. METHODS We analyzed 7‐day wrist actigraphy in 140 adults
Sandra Giménez, Lídia Vaqué‐Alcázar, Susana Clos, Bessy Benejam, Maria Carmona‐Iragui, Lucía Maure‐Blesa, Laura Videla, Nuole Zhu, Miren Altuna, Javier Arranz, Isabel Barroeta, Íñigo Rodríguez‐Baz, Alexandre Bejanin, Ana Bueno, Susana Fernandez, Laura del Hoyo Soriano, Lucia Pertierra, Daniel Alcolea, Bruce Miller, Lea T. Grinberg, Joaquin Ruiz, Christos Panagiotis Lisgaras, Hau‐Tieng Wu, Alberto Lleó, Ricardo S. Osorio, Esther M. Blessing, Juan Fortea   +26 more
wiley   +1 more source

Monochromatic light affects intestinal barrier function of chick via an anti-oxidation pathway involving melatonin and its receptor Mel1b. [PDF]

Poult Sci
Tang W, Wang Z, Dong Y, Cao J, Chen Y.
europepmc   +1 more source

Prevalence and impact of prescribing cascades in community‐dwelling adults: Longitudinal analysis of the Irish longitudinal study on ageing (TILDA)

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1500-1508, May 2026.
Prescribing cascades occur when medication is prescribed to prevent/treat the adverse effects of another medication and may be intentional/unintentional. This study examines the prevalence of nine prescribing cascades (ThinkCascades) in The Irish Longitudinal StuDy on Ageing (TILDA).
Ann Sinéad Doherty, Rose Anne Kenny, Frank Moriarty, Fiona Boland, Barbara Clyne, Tom Fahey, Denis O' Mahony, Emma Wallace   +7 more
wiley   +1 more source

Effects of Melatonin Disorders on Parkinson's Disease: A Review of Mechanisms and Clinical Manifestations. [PDF]

Neuropsychiatr Dis Treat
Shen Y, He C, Wang Y, Zhang Y, Liu Z, Chen X, Wang S, Bai Y.   +7 more
europepmc   +1 more source

Ubiquitin‐Specific Protease 45 Inhibits Lung Adenocarcinoma Ferroptosis by Regulating Ubiquitination and Stability of Glutathione Peroxidase 4

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Lung adenocarcinoma is the most common subtype of lung cancer and the leading cause of cancer‐related mortality worldwide. Ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation, has emerged as a promising therapeutic target for lung adenocarcinoma.
Mingxiang Huang, Meilan Fang, Yao Wang, Shanshan Liu, Fengqin Li   +4 more
wiley   +1 more source

Melatonin as a Guardian of Mitochondria: Mechanisms and Therapeutic Potential in Neurodegenerative Diseases. [PDF]

Biology (Basel)
Bao Y, Miao G, He N, Bao X, Shi Z, Hu C, Liu X, Wang B, Sun C.   +8 more
europepmc   +1 more source

Thyroid dysfunction in African trypanosomiasis [PDF]

, 1993
Allolio, B., Arlt, W., Chrousos, G. P., Heppner, C., Mbulamberi, D., Petzke, F., Reincke, Martin, Siekmann, L., Vollmer, D., Winkelmann, W.   +9 more
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