Results 31 to 40 of about 2,728,981 (353)

Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology [PDF]

, 2013
Cholangiocytes are epithelial cells lining the biliary epithelium. Cholangiocytes play several key roles in the modification of ductal bile and are also the target cells in chronic cholestatic liver diseases (i.e., cholangiopathies) such as PSC, PBC ...
Alvaro, Domenico, Carpino, G, Franchitto, Antonio, Gaudio, Eugenio, Mancinelli, Romina, Onori, Paolo, Renzi, Anastasia   +6 more
core   +1 more source

Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses

BMC Oral Health, 2020
Background Pulpal inflammation is known to be mediated by multiple signaling pathways. However, whether melatonin plays regulatory roles in pulpal inflammation remains unclear.
Nutthapong Kantrong, Piyabhorn Jit-Armart, Uthaiwan Arayatrakoollikit   +2 more
doaj   +1 more source

Melatonin, Melatonin Receptors and Melanophores: A Moving Story [PDF]

Pigment Cell Research, 2004
Melatonin (5‐methoxy N‐acetyltryptamine) is a hormone synthesized and released from the pineal gland at night, which acts on specific high affinity G‐protein coupled receptors to regulate various aspects of physiology and behaviour, including circadian and seasonal responses, and some retinal, cardiovascular and immunological functions.
Sugden, D, Davidson, K, Hough, K A, Teh, M T   +3 more
openaire   +2 more sources

Melatonin signaling modulates clock genes expression in the mouse retina. [PDF]

PLoS ONE, 2014
Previous studies have shown that retinal melatonin plays an important role in the regulation of retinal daily and circadian rhythms. Melatonin exerts its influence by binding to G-protein coupled receptors named melatonin receptor type 1 and type 2 and ...
Susumu Hiragaki, Kenkichi Baba, Elise Coulson, Stefanie Kunst, Rainer Spessert, Gianluca Tosini   +5 more
doaj   +1 more source

Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice

Frontiers in Pharmacology, 2023
Stress may trigger sleep disorders and are also risk factors for depression. The study explored the melatonin-related mechanisms of stress-associated sleep disorders on a mouse model of chronic stress by exploring the alteration in sleep architecture ...
Tian-Ji Xia, Zhi Wang, Su-Wei Jin, Xin-Min Liu, Yong-Guang Liu, Shan-Shan Zhang, Rui-Le Pan, Ning Jiang, Yong-Hong Liao, Ming-Zhu Yan, Li-Da Du, Li-Da Du, Qi Chang   +12 more
doaj   +1 more source

The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth

Journal of Advanced Research, 2022
Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior. Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well ...
Qianhui Sun, Jinrui Zhang, Xiaoxi Li, Guoheng Yang, Shaoxuan Cheng, Dong Guo, Qingqing Zhang, Feng Sun, Feng Zhao, Dian Yang, Shanshan Wang, Taishu Wang, Shuyan Liu, Lijuan Zou, Yingqiu Zhang, Han Liu   +15 more
doaj   +1 more source

From implantation to birth: insight into molecular melatonin functions [PDF]

, 2018
Melatonin is a lipophilic hormone synthesized and secreted mainly in the pineal gland, acting as a neuroendocrine transducer of photoperiodic information during the night.
Carlomagno, Gianfranco, Minini, Mirko, Tilotta, Marco, Unfer, Vittorio   +3 more
core   +1 more source

Circadian Pattern of Melatonin MT1 and MT2 Receptor Localization in the Rat Suprachiasmatic Nucleus

Journal of Circadian Rhythms, 2015
The suprachiasmatic nucleus (SCN) is the circadian pacemaker. The pineal hormone melatonin is involved in the regulation of circadian phase. As a part of the circadian system its synthesis and secretion is under SCN control.
Nermien Waly, Richard Hallworth
doaj   +1 more source

Emerging pharmacotherapy of tinnitus [PDF]

, 2009
Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by about 1 in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life.
Ana Belén Elgoyhen, Azevedo AA, Bahmad FM, Berthold Langguth, Busto U, Courtney KR, Domeisen H, Feder R, Gananca MM, Goebel G, Goodnick PJ, Gresser U, Guitton MJ, Guitton MJ, Hastak SM, Henry JA, Hilton M, Holstein N, House JW, Kuchar DL, Langguth B, Lenarz T, Mahadevan S, Mardini MK, McCabe BF, Melcher JR, Moller AR, Moller AR, Newman CW, Oliver D, Podoshin L, Richard Salvi, Rogawski MA, Roth SH, Schlee W, Shambaugh GE, Shea JJ, Shulman A, Sieghart W, Tandon R, Wei BPC, Williams SH, Willow M, Zapp JJ   +43 more
core   +1 more source

The role of melatonin in diabetes: therapeutic implications

Archives of Endocrinology and Metabolism, 2015
Melatonin referred as the hormone of darkness is mainly secreted by pineal gland, its levels being elevated during night and low during the day. The effects of melatonin on insulin secretion are mediated through the melatonin receptors (MT1 and MT2).
Shweta Sharma, Hemant Singh, Nabeel Ahmad, Priyanka Mishra, Archana Tiwari   +4 more
doaj   +1 more source