Results 231 to 240 of about 2,302,872 (259)

Receptors | Muscarinic Acetylcholine Receptors

Encyclopedia of Biological Chemistry III, 2021
N. Nathanson, Justin J. Miller
semanticscholar   +1 more source

Endocytosis and recycling of muscarinic receptors

Life Sciences, 1999
Agonist stimulation causes the endocytosis of many G protein-coupled receptors, including muscarinic acetylcholine receptors. In this study we have investigated the agonist-triggered trafficking of the M3 muscarinic receptor expressed in SH-SY5Y human neuroblastoma cells.
J. Michael Edwardson, Philip G. Szekeres
openaire   +3 more sources

Muscarinic Acetylcholine Receptors

1988
The central and peripheral actions of the endogenous neurotransmitter acetylcholine (ACh) are exerted at two main types of receptor, present in both the central and peripheral nervous system of all mammals. Their definition and pharmacological classification dates back to the work of Sir Henry Dale (1914), who demonstrated that certain actions of ACh ...
J. Järv, Tamas Bartfai
openaire   +2 more sources

Constitutively active muscarinic receptors

Life Sciences, 2001
Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin.
Ethan S. Burstein, Tracy A. Spalding
openaire   +2 more sources

Functional nicotinic and muscarinic receptors on mesenchymal stem cells.

Stem Cells and Development, 2009
Mesenchymal stem cells (MSCs) are under the control of a large number of signaling systems. In this study, the presence and functionality of the acetylcholine (ACh) signaling system in MSCs was examined.
M. Hoogduijn, A. Cheng, P. Genever
semanticscholar   +1 more source

Muscarinic receptors revisited

Trends in Neurosciences, 1983
Abstract It is now thought that muscarinic acetylcholine receptors are not identical, and the evidence for this is reviewed briefly, with emphasis on functional studies. In the brain, there is evidence that different subtypes of muscarinic receptors are localized in different regions and there are early suggestions that these may have distinct ...
Malcolm Caulfield, Donald W. Straughan
openaire   +2 more sources

Muscarinic receptors in the ocular surface

Current Opinion in Allergy & Clinical Immunology, 2006
A wide distribution of the eye's muscarinic receptor system has been found and several roles for the muscarinic system in the eye proposed, although functional consequences of muscarinic receptor activation are not always fully characterized. The present paper reviews current knowledge about the presence of muscarinic receptors in the ocular surface ...
Amalia Enríquez-de-Salamanca, Margarita Calonge   +1 more
openaire   +3 more sources

Muscarinic receptors in the Mammalian Heart

Pharmacological Research, 2001
In the mammalian heart, cardiac function is under the control of the sympathetic and parasympathetic nervous system. All regions of the mammalian heart are innervated by parasympathetic (vagal) nerves, although the supraventricular tissues are more densely innervated than the ventricles.
Chris J. van Koppen, Stefan Dhein, Otto-Erich Brodde   +2 more
openaire   +3 more sources

CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment

This review explores the main aspects that form the basis of the cholinergic-oriented treatment of Alzheimer disease. Muscarinic acetylcholine receptor subtypes in the brain and periphery are discussed. It includes a new and updated overview of the involvement of muscarinic receptors in Alzheimer disease and the recent development of new and highly ...
Abraham, Fisher, Allan I, Levey
openaire   +2 more sources

Muscarinic receptors in human airways

Journal of Allergy and Clinical Immunology, 1995
Muscarinic receptors play a double role in airway disorders, mediating an increase in mucus secretion, as well as constriction of smooth muscle. Cholinergic activity of the lung is more pronounced in large than in peripheral airways; in the nose parasympathetic stimulation leads to hypersecretion and vasodilation.
openaire   +3 more sources