Results 231 to 240 of about 41,494 (257)
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Current Protocols in Pharmacology, 1999
AbstractIn the central and peripheral nervous systems, the actions of acetylcholine are mediated by families of ligand gated ion channels and metabotropic receptors. The latter family is composed of muscarinic receptors, since they are selectively activated by muscarine and antagonized by atropine. Five muscarinic receptor subtypes have been identified
Richard M. Eglen +3 more
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AbstractIn the central and peripheral nervous systems, the actions of acetylcholine are mediated by families of ligand gated ion channels and metabotropic receptors. The latter family is composed of muscarinic receptors, since they are selectively activated by muscarine and antagonized by atropine. Five muscarinic receptor subtypes have been identified
Richard M. Eglen +3 more
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Heterogeneity of vascular muscarinic receptors
Journal of Autonomic Pharmacology, 1990SummaryMuscarinic receptors mediate diverse effects on the vasculature. Recently, a consensus has been arrived at with regard to muscarinic receptor classification (Levine and Birdsall, 1989). As a result, it may now be possible to clarify the role of each subtype in the responses of vascular tissues to muscarinic agonists. It is apparent that vascular
R. L. Whiting, R. M. Eglen
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Regulation of muscarinic M2 receptors
Life Sciences, 1997The molecular mechanisms involved in the regulation of muscarinic receptor gene expression are poorly understood. In an effort to gain a better understanding of the regulation of M2 receptors, we have investigated homologous and heterologous regulation of M2 muscarinic receptor protein and gene expression in human embryonic lung fibroblasts (HEL 299 ...
Jonathan Rousell +2 more
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Interaction of Atropine with the Muscarinic Receptor
Nature, 1970WE report here the crystal structures of two muscarinic antagonists of acetylcholine, (−)-(S)-hyoscine hydrobromide1 and (−)-(S)-hyoscyamine hydrobromide (atropine). Correlation of these two structures and that of quinuclidinyl benzilate hydrobromide2 shows marked similarities among the three molecules although they are subjected to very different ...
Trevor J. Petcher, Peter Pauling
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Muscarinic Acetylcholine Receptors
2004Muscarinic acetylcholine receptors are members of the G-protein-coupled receptor superfamily. There are five genes encoding the muscarinic receptors, which are expressed to different extents in a variety of tissues, including cardiac and smooth muscle, secretory glands, and neurons and glial cells in the central and peripheral nervous systems ...
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Structure and Regulation of Muscarinic Receptors
Annual Review of Physiology, 1989Our knowledge of muscarinic receptor structure, mechanism, and regulation has increased enormously over the past five years. At this time, expression of receptor subtype and coupling via signal transducing elements to specific effector systems seems to be cell or tissue specific events.
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Muscarinic receptor subtypes in airways
European Respiratory Journal, 1993Muscarinic receptor subtypes in the airways appear to subserve different physiological functions. M1-receptors facilitate neurotransmission through parasympathetic ganglia and enhance cholinergic reflexes, but are also localized to alveolar walls. M2-receptors act as autoreceptors on post-ganglionic cholinergic nerves and inhibit acetylcholine release.
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Endocytosis and recycling of muscarinic receptors
Life Sciences, 1999Agonist stimulation causes the endocytosis of many G protein-coupled receptors, including muscarinic acetylcholine receptors. In this study we have investigated the agonist-triggered trafficking of the M3 muscarinic receptor expressed in SH-SY5Y human neuroblastoma cells.
J. Michael Edwardson, Philip G. Szekeres
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Constitutively active muscarinic receptors
Life Sciences, 2001Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin.
Ethan S. Burstein, Tracy A. Spalding
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Muscarinic Acetylcholine Receptors
1988The central and peripheral actions of the endogenous neurotransmitter acetylcholine (ACh) are exerted at two main types of receptor, present in both the central and peripheral nervous system of all mammals. Their definition and pharmacological classification dates back to the work of Sir Henry Dale (1914), who demonstrated that certain actions of ACh ...
J. Järv, Tamas Bartfai
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