Results 61 to 70 of about 41,494 (257)

Detection in Molecular Communications with Ligand Receptors under Molecular Interference [PDF]

arXiv, 2020
Molecular Communications (MC) is a bio-inspired communication technique that uses molecules to transfer information among bio-nano devices. In this paper, we focus on the detection problem for biological MC receivers employing ligand receptors to infer the transmitted messages encoded into the concentration of molecules, i.e., ligands.
arxiv  

Finerenone, chronic obstructive pulmonary disease, and heart failure with mildly reduced or preserved ejection fraction: A prespecified analysis of the FINEARTS‐HF trial

European Journal of Heart Failure, EarlyView.
The beneficial effects of finerenone in patients with heart failure (HF) and mildly reduced or preserved ejection fraction were consistent, regardless of a history of chronic obstructive pulmonary disease (COPD) status. BMI, body mass index; LVEF, left ventricular ejection fraction; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide.
Jawad H. Butt, Pardeep S. Jhund, Alasdair D. Henderson, Brian L. Claggett, Akshay S. Desai, Carolyn S.P. Lam, Katharina Mueller, Markus F. Scheerer, Prabhakar Viswanathan, Michele Senni, Sanjiv J. Shah, Adriaan A. Voors, Faiez Zannad, Bertram Pitt, Muthiah Vaduganathan, Scott D. Solomon, John J.V. McMurray   +16 more
wiley   +1 more source

Reversal of rocuronium‐induced intense neuromuscular blockade by sugammadex in Korean children: A pharmacokinetic and pharmacodynamic analysis

Clinical and Translational Science, Volume 16, Issue 1, Page 92-103, January 2023., 2023
Abstract Sugammadex, a selective antagonist of steroidal non‐depolarizing neuromuscular blocking agents, has been used in children in limited circumstances. However, neither pharmacokinetics (PKs) nor recovery profile of sugammadex for intense neuromuscular blockade reversal in children have been reported.
Sang‐Hwan Ji, Ki Young Huh, Jaeseong Oh, Hee‐Jeong Jeong, Young‐Eun Jang, Eun‐Hee Kim, Ji‐Hyun Lee, Jin‐Tae Kim, Hee‐Soo Kim   +8 more
wiley   +1 more source

Peripheral muscarinic receptors mediate the anti-inflammatory effects of auricular acupuncture

Chinese Medicine, 2011
Background The cholinergic and opioid systems play important roles in modulating inflammation. This study tests whether auricular acupuncture (AA) produces anti-inflammatory effects via opioid and peripheral cholinergic receptors in a rat model.
Chung Wai, Zhang Hong, Zhang Shi
doaj   +1 more source

Polypharmacy with tiagabine, levetiracetam, and perampanel in status epilepticus: Insights from EEG, biochemical, and histopathological studies in rats

Epilepsia Open, EarlyView.
Abstract Objective Status epilepticus (SE) is a condition of neurological emergency, which precipitates various functional and morphological changes in the brain. Due to the risk of drug resistance associated with SE, this study aimed to evaluate a multitargeted approach to treat SE by combining clinically used antiseizure drugs. Methods In this study,
Sana Javaid, Faleh Alqahtani, Abida Parveen, Waseem Ashraf, Zohabia Rehman, Syed Muhammad Muneeb Anjum, Tanveer Ahmad, Imran Imran   +7 more
wiley   +1 more source

Exploiting the molecular diversity of the synapse to investigate neuronal communication: A guide through the current toolkit

European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022
Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna, Mattia Ferro, Sara Spadini, Antonio Malgaroli   +3 more
wiley   +1 more source

Harnessing Jasminum Bioactive Compounds: Updated Insights for Therapeutic and Food Preservation Innovations

Food Frontiers, EarlyView.
Jasminum bioactives improve food preservation by providing antimicrobial and antioxidant effects, especially when incorporated into active packaging, edible films, and nanoformulations that enhance stability and controlled release. They also offer many pharmacological benefits, including anti‐inflammatory, neuroprotective, and wound‐healing properties.
Antonio Rescigno, Paolo Zucca, Stefania Peddio, Sriranjani Srikanth, Niharika Prakash Kaushik, Nanjangud Venkatesh Anil Kumar, Gerardo Leyva‐Gómez, Dorota Kregiel, Ibrahim M. Abu‐Reidah, Surjit Sen, Krishnendu Acharya, William N. Setzer, Marta Palma‐Morales, Miquel Martorell, Daniela Calina, Celia Rodríguez‐Pérez, Javad Sharifi‐Rad, William C. Cho   +17 more
wiley   +1 more source

Decreased expression and impaired function of muscarinic acetylcholine receptors in the rat hippocampus following transient forebrain ischemia

Neurobiology of Disease, 2005
In this study, we investigated whether transient cerebral ischemia affects the function and molecular expression of specific muscarinic cholinergic receptors.
Guangming Zhang, Liang Zhang, Richard Logan, Benjamin P. Jung, Darren Yuen, Jee Ching Hsu, James H. Eubanks   +6 more
doaj  

Structure and dynamics of dynorphin peptide and its receptor [PDF]

arXiv, 2019
Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G-protein coupled receptors. The dynorphin peptide was discovered in 1975, while its receptor was cloned in 1993.
arxiv  

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source