Results 111 to 120 of about 38,001 (122)

Memantine Blocks α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors in Rat Hippocampal Neurons

Journal of Pharmacology and Experimental Therapeutics, 2005
The N-methyl-d-aspartate (NMDA) receptor antagonist memantine is an approved drug for treatment of Alzheimer's disease (AD). Other such treatments are cholinesterase inhibitors and nicotinic acetylcholine receptor (nAChR)-sensitizing agents such as ...
Y. Aracava, E. Pereira, A. Maelicke, E. Albuquerque   +3 more
semanticscholar   +1 more source

Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats.

Gastroenterology, 2001
BACKGROUND & AIMS N-methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels that have an important role in long-term potentiation and memory processing in the central nervous system.
J. McRoberts, S. V. Coutinho, J. Marvizón, E. Grady, M. Tognetto, J. Sengupta, H. Ennes, V. Chaban, S. Amadesi, C. Créminon, T. Lanthorn, P. Geppetti, N. Bunnett, E. Mayer   +13 more
semanticscholar   +1 more source

Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore.

Molecular Pharmacology, 2002
A large number of structurally diverse compounds act as open-channel blockers of NMDA receptors. They may share discrete or overlapping binding sites within the channel. In this study, the effects of mutations in and around the membrane-spanning and pore-
K. Kashiwagi, T. Masuko, Christopher D. Nguyen, T. Kuno, Ikuko Tanaka, K. Igarashi, K. Williams   +6 more
semanticscholar   +1 more source

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

Molecular Pharmacology, 1993
K. Williams
semanticscholar   +1 more source

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

Nature, 1986
R. Morris, Elizabeth W. Anderson, G. Lynch, M. Baudry   +3 more
semanticscholar   +1 more source

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

Brain Research, 1984
E. Harris, A. Ganong, C. Cotman
semanticscholar   +1 more source

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

Pharmacological Reviews, 1998
W. Danysz, C. Parsons
semanticscholar   +1 more source

Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

Nature, 1990
S. Traynelis, S. Cull-Candy
semanticscholar   +1 more source

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.

Journal of Pharmacology and Experimental Therapeutics, 1997
G. Fischer, V. Mutel, G. Trube, P. Malherbe, J. Kew, E. Mohacsi, M. Heitz, J. Kemp   +7 more
semanticscholar   +1 more source

Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions.

International review of neurobiology, 2007
D. Javitt
semanticscholar   +1 more source