Results 111 to 120 of about 155,151 (336)
Different Sites of Alcohol Action in the NMDA Receptor GluN2A and GluN2B Subunits [PDF]
, 2015 The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action.
Allgaier +68 more
core +2 more sources
Advanced Science, EarlyView.To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao +12 more
wiley +1 more source
New Therapeutic Strategy for Amino Acid Medicine: Glycine Improves the Quality of Sleep
Journal of Pharmacological Sciences, 2012 Glycine is a non-essential amino acid that has indispensable roles in both excitatory and inhibitory neurotransmission via N-methyl-D-aspartate type glutamate receptors and glycine receptors, respectively.
Makoto Bannai, Nobuhiro Kawai
doaj +1 more source
Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids. [PDF]
, 2019 Tramadol is one of the most commonly used analgesics worldwide, classified as having a low abuse potential by U.S. Drug Enforcement Agency, and often recommended in pain management guidelines.
Abagyan, Ruben +3 more
core +1 more source
Limits of feedback control in bacterial chemotaxis
, 2014 Inputs to signaling pathways can have complex statistics that depend on the environment and on the behavioral response to previous stimuli. Such behavioral feedback is particularly important in navigation.
Dufour, Yann S. +3 more
core +3 more sources
The gut-brain axis, BDNF, NMDA and CNS disorders [PDF]
, 2016 Gastro-intestinal (GI) microbiota and the ‘gut-brain axis’ are proving to be increasingly relevant to early brain development and the emergence of psychiatric disorders.
Maqsood, Raeesah, Stone, Trevor W.
core +1 more source
Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact
Advanced Science, EarlyView.Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou +16 more
wiley +1 more source
Dual Action of Memantine in Alzheimer Disease: A Hypothesis
Taiwanese Journal of Obstetrics & Gynecology, 2009 Objective: In this study, we proposed a hypothesis to explain the mechanisms of memantine action in treating Alzheimer disease (AD). Memantine may reduce the expression of amyloid precursor protein and tau protein, as well as acting as an antagonist of N-
Tzong-Yuan Wu, Chih-Ping Chen
doaj +1 more source
The Effects of Serotonin on Functionally Diverse Isolated Lamprey Spinal Cord Neurons [PDF]
, 2002 The experiments reported here showed that application of serotonin (5-hydroxytryptamine, 5-HT) (100 µ M) did not induce any significant current through the membranes of any of the spinal neurons studied (n = 62).
Batueva, I. V. +4 more
core +1 more source
Journal of Biological Chemistry, 2006 Alzheimer disease (AD) is a progressive, neurodegenerative disorder that leads to debilitating cognitive deficits. Although little is known about the early functional or ultrastructural changes associated with AD, it has been proposed that a stage of ...
Brent L. Kelly, Adriana Ferreira
semanticscholar +1 more source