Results 291 to 300 of about 156,800 (338)

Allosteric Modulation of N-Methyl-D-Aspartate Receptors

1990
In this review we have attempted to describe the basis for current models of the NMDA receptor, and justify the need for the various binding sites that have been proposed. The NMDA receptor is clearly a complex molecule with a number of modulatory sites, any of which may have great functional significance.
I J, Reynolds, R J, Miller
openaire   +2 more sources

N-methyl-d-aspartate receptors and pain

Current Opinion in Anaesthesiology, 1995
The N-methyl-d-aspartate subtype of excitatory amino acid receptor is abundantly distributed throughout the central nervous system and is intimately associated with physiologic processes underlying acute and chronic pain states.
Andrew W. Sukiennik, Richard M. Kream
openaire   +1 more source

GRINL1A colocalizes with N-methyl D-aspartate receptor NR1 subunit and reduces N-methyl D-aspartate toxicity

NeuroReport, 2008
We hypothesized that proteins from the GRINL1A complex transcription unit called Gcom proteins modulate glutamatergic neurotransmission through interaction with the NR1 subunit of the N-methyl D-aspartate (NMDA) receptor. Cotransfection of hemagglutinin-tagged Gcom1 (GRINL1A combined transcript 1) and NR1 cDNAs into HEK293 cells revealed overlapping ...
Raymond S, Roginski, Farida, Goubaeva, Maya, Mikami, Emma, Fried-Cassorla, Mohan R, Nair, Jay, Yang   +5 more
openaire   +2 more sources

Modeling of N-Methyl-D-Aspartate Receptors

2019
Several reduced kinetic models for N-methyl-D-aspartate receptors were derived in order to suit different experimental protocols. Their simultaneous application allows for a step-wise estimation of parameters of a conventional model that is otherwise overparameterized with respect to the existing data.
Denis Shchepakin, Leonid Kalachev, Michael Kavanaugh   +2 more
openaire   +1 more source

Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.

Science, 1984
R. Simon, J. H. Swan, T. Griffiths, B. Meldrum   +3 more
semanticscholar   +1 more source

Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.

Molecular Pharmacology, 1993
K. Williams
semanticscholar   +1 more source

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

Nature, 1986
R. Morris, Elizabeth W. Anderson, G. Lynch, M. Baudry   +3 more
semanticscholar   +1 more source

Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors.

Journal of Neurophysiology, 1998
S. Vicini, Jian Feng Wang, Jinhong Li, W. Zhu, Yue‐hua Wang, Jian‐hong Luo, B. Wolfe, D. Grayson   +7 more
semanticscholar   +1 more source

Excitotoxicity and N‐methyl‐D‐Aspartate receptors

Drug Development Research, 1989
AbstractA great deal of new information has been generated over the past decade in the excitatory amino acid (EAA) field. Not only have endogenous EAA such as glutamate and aspartate become recognized as the leading neurotransmitter candidates at the majority of excitatory synapses in the mammalian central nervous system, but it is becoming ...
openaire   +1 more source

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

Brain Research, 1984
E. Harris, A. Ganong, C. Cotman
semanticscholar   +1 more source