New antagonist agents of neuropeptide y receptors [PDF]
Química Nova, 2000 In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists will be able to probe the merits of this approach for the treatment of obesity.
Ignacio Aldana +8 more
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Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells. [PDF]
PLoS ONE, 2013 Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related hypertension with SNS activation accelerates progression of non-alcoholic fatty liver disease (NAFLD ...
Barbara Sigala +11 more
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Empowering exhausted T cells of Glioblastoma patients by Neurotransmitters and Neuropeptides: decreasing immune checkpoint inhibitors, and increasing CD3zeta, proliferation and Glioblastoma arrest [PDF]
Cancer Immunology, ImmunotherapyBackground Glioblastoma is the most common malignant brain tumor, with extremely poor prognosis, and patient’s T cells are exhausted, dysfunctional, and unable to eliminate Glioblastoma.
Mia Levite +3 more
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Evolution of neuropeptide Y/RFamide-like receptors in nematodes
HeliyonThe Neuropeptide Y/RFamide-like receptors belong to the Rhodopsin-like G protein-coupled receptors G protein-coupled receptors (GPCRs) and are involved in functions such as locomotion, feeding and reproduction.
Franziska Reinhardt +3 more
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pH-dependent structural dynamics of neuropeptide Y in aqueous solution. [PDF]
PLoS ONENeuropeptide Y regulates key molecular processes in the brain. Its interaction with the cell membrane, where it binds to specialized receptors with key physiological roles, likely depends on pH.
Hoa Thi Nguyen +3 more
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Neuropeptide Y receptors: How to get subtype selectivity [PDF]
Frontiers in Endocrinology, 2013 The neuropeptide Y system is a multireceptor/multiligand system consisting of four receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate these receptors with different potency.
Xavier ePedragosa Badia +2 more
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Characterization and deorphanization of RYamide signaling in Aedes aegypti: A potential regulator of hindgut-associated physiology. [PDF]
PLoS ONENeuropeptide Y-related signaling, consisting of various neuropeptides and their receptors including, for example, the mammalian neuropeptide Y (NPY), pancreatic polypeptide (PP), and peptide YY (PYY) families, along with neuropeptide Y-like peptides in ...
Jinghan Tan +2 more
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Development of neuropeptide Y-ergic innervation of the small intestine in rats
Учёные записки Казанского университета: Серия Естественные науки, 2018 Neuropeptide Y (NPY) acts as a neurotransmitter in the autonomic nervous system, including in the metasympathetic intramural ganglia of the intestine.
P.M. Masliukov +3 more
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The therapeutic effects of labetalol in chronic stress- and immuno-agonist-induced cough hypersensitivity and lung inflammation involve reducing interferon-γ-producing T lymphocytes [PDF]
ERJ Open ResearchBackground Psychological stress correlates with chronic cough, which is often triggered by respiratory viruses. Chronic stress promotes sympathetic nerves to release norepinephrine and neuropeptide Y.
Tongtong Song +7 more
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Effects of neuropeptide Y on electrical activity and myocardial contractility
Учёные записки Казанского университета: Серия Естественные науки, 2018 Neuropeptide Y (NPY) and agonist Leu(31)Pro(34)NPY were used to determine the type of NPY receptors involved in electrical activity and myocardial contraction.
A.A. Zverev +6 more
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