Results 11 to 20 of about 21,072,923 (152)

Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells. [PDF]

PLoS ONE, 2013
Sympathetic nervous system (SNS) signalling regulates murine hepatic fibrogenesis through effects on hepatic stellate cells (HSC), and obesity-related hypertension with SNS activation accelerates progression of non-alcoholic fatty liver disease (NAFLD ...
Barbara Sigala, Chad McKee, Junpei Soeda, Valerio Pazienza, Maelle Morgan, Ching-I Lin, Clare Selden, Sara Vander Borght, Gianluigi Mazzoccoli, Tania Roskams, Manlio Vinciguerra, Jude A Oben   +11 more
doaj   +3 more sources

Evolution of neuropeptide Y/RFamide-like receptors in nematodes

Heliyon
The Neuropeptide Y/RFamide-like receptors belong to the Rhodopsin-like G protein-coupled receptors G protein-coupled receptors (GPCRs) and are involved in functions such as locomotion, feeding and reproduction.
Franziska Reinhardt, Anette Kaiser, Simone Prömel, Peter F. Stadler   +3 more
doaj   +2 more sources

Empowering exhausted T cells of Glioblastoma patients by Neurotransmitters and Neuropeptides: decreasing immune checkpoint inhibitors, and increasing CD3zeta, proliferation and Glioblastoma arrest [PDF]

Cancer Immunology, Immunotherapy
Background Glioblastoma is the most common malignant brain tumor, with extremely poor prognosis, and patient’s T cells are exhausted, dysfunctional, and unable to eliminate Glioblastoma.
Mia Levite, Nili Ilouz, Eithan Galun, Yigal Shoshan   +3 more
doaj   +2 more sources

pH-dependent structural dynamics of neuropeptide Y in aqueous solution. [PDF]

PLoS ONE
Neuropeptide Y regulates key molecular processes in the brain. Its interaction with the cell membrane, where it binds to specialized receptors with key physiological roles, likely depends on pH.
Hoa Thi Nguyen, Marc Spehr, Ana-Nicoleta Bondar, Paolo Carloni   +3 more
doaj   +2 more sources

Development of neuropeptide Y-ergic innervation of the small intestine in rats

Учёные записки Казанского университета: Серия Естественные науки, 2018
Neuropeptide Y (NPY) acts as a neurotransmitter in the autonomic nervous system, including in the metasympathetic intramural ganglia of the intestine.
P.M. Masliukov, J.P. Timmermans, A.A. Zverev, T.L. Zefirov   +3 more
doaj   +1 more source

Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state

Cell Communication and Signaling, 2020
Background A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y2 receptor (hY2R) undergoes ligand dependent activation and internalization into ...
Isabelle Ziffert, Anette Kaiser, Stefanie Babilon, Karin Mörl, Annette G. Beck-Sickinger   +4 more
doaj   +1 more source

PET Imaging of the Neuropeptide Y System: A Systematic Review

Molecules, 2022
Neuropeptide Y (NPY) is a vastly studied biological peptide with numerous physiological functions that activate the NPY receptor family (Y1, Y2, Y4 and Y5).
Inês C. F. Fonseca, Miguel Castelo-Branco, Cláudia Cavadas, Antero J. Abrunhosa   +3 more
doaj   +1 more source

Effects of neuropeptide Y on electrical activity and myocardial contractility

Учёные записки Казанского университета: Серия Естественные науки, 2018
Neuropeptide Y (NPY) and agonist Leu(31)Pro(34)NPY were used to determine the type of NPY receptors involved in electrical activity and myocardial contraction.
A.A. Zverev, T.A. Anikina, N.G. Iskakov, A.V. Krulova, P.M. Masliukov, J.P. Timmermans, T.L. Zefirov   +6 more
doaj   +1 more source

Neuropeptide Y receptors in GtoPdb v.2023.1 [PDF]

, 2023
Neuropeptide Y (NPY) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Neuropeptide Y Receptors [158]) are activated by the endogenous peptides neuropeptide Y, neuropeptide Y-(3-36), peptide YY, PYY-(3-36) and pancreatic polypeptide (PP).
Cox, Helen M., Thue Schwartz, Dan Larhammar, Helen M. Cox, Beck-Sickinger, Annette G., Herzog, Herbert, Thomas Westfall, Michel, Martin C., Larhammar, Dan, Westfall, Thomas, Martin C. Michel, Remi Quirion, Schwartz, Thue, William F. Colmers, Henri N. Doods, Doods, Henri N., Quirion, Remi, Colmers, William F., Annette G. Beck-Sickinger, Herbert Herzog   +19 more
core   +1 more source

Echinoderms provide missing link in the evolution of PrRP/sNPF-type neuropeptide signalling

eLife, 2020
Neuropeptide signalling systems comprising peptide ligands and cognate receptors are evolutionarily ancient regulators of physiology and behaviour.
Luis Alfonso Yañez-Guerra, Xingxing Zhong, Ismail Moghul, Thomas Butts, Cleidiane G Zampronio, Alexandra M Jones, Olivier Mirabeau, Maurice R Elphick   +7 more
doaj   +1 more source