Results 261 to 270 of about 2,426,956 (334)

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source

Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment. [PDF]

Front Pain Res (Lausanne)
Souissi A, Prieto-González P, Ben Saad H.   +2 more
europepmc   +1 more source

Factors Influencing Co‐Use of Tobacco and Cannabis Amongst Young Adults in UK Further Education Colleges: A Qualitative Study

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction Tobacco and cannabis are commonly co‐used (i.e., used concurrently or co‐administered) but rarely ‘co‐addressed’ and few co‐use interventions exist. Young adulthood presents a key age for intervening in substance use, therefore understanding young adults' perspective is crucial, but little is known about how they understand or ...
Hannah Walsh, Ann McNeill, Maria Duaso
wiley   +1 more source

In silico approaches for developing sesquiterpene derivatives as antagonists of human nicotinic acetylcholine receptors (nAChRs) for nicotine addiction treatment. [PDF]

Curr Res Struct Biol
Fakih TM, Rizkita AD, Dewi SA, Muchtaridi M.   +3 more
europepmc   +1 more source

Nicotinic acetylcholine receptors regulate growth hormone in pituitary somatotrophs of tigers. [PDF]

Commun Biol
Liu L, Yang S, Chai L, Zhang S, Liu D, Xu H, Zhao Y, Chen S, Jiang G, Li B.   +9 more
europepmc   +1 more source

Real‐world insights into incretin‐based therapy: Associations between changes in taste perception and appetite regulation in individuals with obesity and overweight: A cross‐sectional study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This cross‐sectional study examined associations between self‐reported taste perception changes and appetite‐related outcomes in individuals with obesity treated with glucagon‐like peptide‐1 receptor agonist (GLP‐1 RAS) or dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1 RAS in real‐world conditions.
Ali Kapan, Othmar Moser, Richard Felsinger, Thomas Waldhoer, Sandra Haider   +4 more
wiley   +1 more source

Long-term muscarinic inhibition increases intrinsic excitability through the upregulation of A-type potassium currents in cortical neurons. [PDF]

Front Cell Dev Biol
Riquelme D, Romo-Toledo P, Leyton P, Moreno C, Leiva-Salcedo E.   +4 more
europepmc   +1 more source

Expression of Neuronal Nicotinic Acetylcholine Receptor and Early Oxidative DNA Damage in Aging Rat Brain-The Effects of Memantine. [PDF]

Int J Mol Sci
Lewandowska MA, Różycka A, Grzelak T, Kempisty B, Jagodziński PP, Lianeri M, Dorszewska J.   +6 more
europepmc   +1 more source

d‐amino acids: new functional insights

The FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source

In vivo and in silico models of Drosophila for Parkinson's disease

The FEBS Journal, EarlyView.
In vivo and in silico models of Drosophila offer valuable advantages in the generation, analysis, and interpretation of complex biological data, thereby significantly advancing our understanding of Parkinson's disease. Molecular‐level measurements and phenotypic data from Drosophila are extensively utilised in metabolic network modeling and artificial ...
Müberra Fatma Cesur, Rachel Strazdins, Souvarish Sarkar, Tunahan Çakır   +3 more
wiley   +1 more source