Results 271 to 280 of about 2,466,892 (329)

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Investigating Therapeutic Targets for Alcohol Use Disorder: Pharmacological View of ClinicalTrials.gov Data. [PDF]

Int J Gen Med
Alorfi NM.
europepmc   +1 more source

Neuroimmune interactions in inflammatory bowel disease: Role of intestinal macrophages and the cholinergic pathway. [PDF]

World J Gastroenterol
Zheng L, Duan SL.
europepmc   +1 more source

Liraglutide modulates cyclooxygenase and α7 acetylcholine receptors: in vitro and in silico insights into its anti-inflammatory role in LPS-induced inflammation in RAW 264.7 macrophages. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Baris E, Portakal HS, Aslan A, Firtina Karagonlar Z, Tosun M.   +4 more
europepmc   +1 more source

Role of physical exercise, vagal nerve stimulation, and vagotomy in inflammatory bowel disease. [PDF]

World J Gastroenterol
da Silva ACA, Severo JS, Dos Santos BLB, Soares HS, Martins JA, Lima RSP, Gadelha KKL, Torres-Leal FL, Correia-de-Sá P, Magalhães PJC, Santos AA, da Silva MTB.   +11 more
europepmc   +1 more source

Effects of Nicotine on SH-SY5Y Cells: An NMR-Based Metabolomic Study. [PDF]

Metabolites
Napolitano E, Marino C, Grimaldi M, Buonocore M, D'Ursi AM.   +4 more
europepmc   +1 more source

Neural regulation of lung cancer: from mechanisms to clinical implications. [PDF]

Eur J Med Res
Xu L, Sun X, Yao Y, Fang H.
europepmc   +1 more source

Functional deletion of α7 nicotinic acetylcholine receptor impairs Ca²⁺-dependent glutamatergic synaptic transmission by affecting both presynaptic and postsynaptic protein expression and function. [PDF]

Front Physiol
Cannata B, Sposito L, Albini M, Aceto G, Puliatti G, Lazzarino G, Ripoli C, Tropea MR, Puzzo D, Piacentini R, Grassi C.   +10 more
europepmc   +1 more source

Increased Cardiovascular Risk in Chronic Spontaneous Urticaria: A Large Real‐World Cohort Study

Allergy, EarlyView.
Philip Curman, Diamant Thaçi, Ralf J. Ludwig   +2 more
wiley   +1 more source