Results 21 to 30 of about 46,003 (163)
Nicotinic acetylcholine receptors and epilepsy
Pharmacological Research, 2023 Despite recent advances in understanding the causes of epilepsy, especially the genetic, comprehending the biological mechanisms that lead to the epileptic phenotype remains difficult.
Andrea Becchetti +3 more
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Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. [PDF]
PLoS ONE, 2011 Chronic UV skin exposure leads to epidermal differentiation defects in humans that can be largely restored by pharmacological doses of nicotinic acid. Nicotinic acid has been identified as a ligand for the human G-protein-coupled receptors GPR109A and ...
Yira Bermudez +5 more
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α9-Containing Nicotinic Receptors in Cancer
Frontiers in Cellular Neuroscience, 2022 Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly express α9-containing receptors, and a number of studies have shown ...
Susanna Pucci +6 more
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Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia
Neurobiology of Disease, 2019 Trihexyphenidyl, a nonselective muscarinic receptor antagonist, is the small molecule drug of choice for the treatment of DYT1 dystonia, but it is poorly tolerated due to significant side effects.
Anthony M. Downs +4 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2015 Prefrontal layer 6 (L6) pyramidal neurons play an important role in the adult control of attention, facilitated by their strong activation by nicotinic acetylcholine receptors.
Lily eKang +6 more
doaj +1 more source
Medicina, 2015 Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas +2 more
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Alcohol and nicotinic acetylcholine receptors [PDF]
QScience Connect, 2013 Background The frequent co-abuse of alcohol and tobacco may suggest that they share some common neurological mechanisms. For example, nicotine acts on Nicotinic acetylcholine receptors (nAChRs) in the brain to release dopamine to sustain addiction. Might
Jinsong Tang, Yanhui Liao
doaj +1 more source
Pharmacological Research, 2023 Initiated by findings that Alzheimer’s disease is associated with a profound loss of cholinergic markers in human brain, decades of studies have examined the interactions between specific subtypes of nicotinic acetylcholine receptors and amyloid-β ...
Paul Whiteaker, Andrew A. George
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Structural interplay of anesthetics and paralytics on muscle nicotinic receptors
Nature Communications, 2023 General anesthetics and neuromuscular blockers are used together during surgery to stabilize patients in an unconscious state. Anesthetics act mainly by potentiating inhibitory ion channels and inhibiting excitatory ion channels, with the net effect of ...
Umang Goswami +3 more
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Variants in Nicotinic Receptors and Risk for Nicotine Dependence [PDF]
American Journal of Psychiatry, 2008 A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5). The purpose of this study was to replicate these findings in an independent data set and more thoroughly ...
Laura Jean, Bierut +32 more
openaire +2 more sources