Results 21 to 30 of about 55,979 (309)

Ingestion of A Common Plant’s Leaves Leads to Acute Respiratory Arrest and Paralysis: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Background: Nicotiana glauca is a plant known to cause acute toxicity upon ingestion or dermal exposure due to the nicotinic alkaloid, anabasine. Nicotinic alkaloids cause toxicity by acting as agonists on nicotinic-type acetylcholine receptors (nAChRs).
Breelan M. Kear, Richard W. Lee, Sanford B. Church, Fady A. Youssef, Anthony Arguija   +4 more
doaj   +1 more source

Nicotine inhibits memory CTL programming. [PDF]

PLoS ONE, 2013
Nicotine is the main tobacco component responsible for tobacco addiction and is used extensively in smoking and smoking cessation therapies. However, little is known about its effects on the immune system.
Zhifeng Sun, Kendra Smyth, Karla Garcia, Elliot Mattson, Lei Li, Zhengguo Xiao   +5 more
doaj   +1 more source

Nicotinic acetylcholine receptors and epilepsy

Pharmacological Research, 2023
Despite recent advances in understanding the causes of epilepsy, especially the genetic, comprehending the biological mechanisms that lead to the epileptic phenotype remains difficult.
Andrea Becchetti, Laura Clara Grandi, Marta Cerina, Alida Amadeo   +3 more
doaj   +1 more source

α9-Containing Nicotinic Receptors in Cancer

Frontiers in Cellular Neuroscience, 2022
Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly express α9-containing receptors, and a number of studies have shown ...
Susanna Pucci, Susanna Pucci, Michele Zoli, Francesco Clementi, Francesco Clementi, Cecilia Gotti, Cecilia Gotti   +6 more
doaj   +1 more source

Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. [PDF]

PLoS ONE, 2011
Chronic UV skin exposure leads to epidermal differentiation defects in humans that can be largely restored by pharmacological doses of nicotinic acid. Nicotinic acid has been identified as a ligand for the human G-protein-coupled receptors GPR109A and ...
Yira Bermudez, Claudia A Benavente, Ralph G Meyer, W Russell Coyle, Myron K Jacobson, Elaine L Jacobson   +5 more
doaj   +1 more source

Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia

Neurobiology of Disease, 2019
Trihexyphenidyl, a nonselective muscarinic receptor antagonist, is the small molecule drug of choice for the treatment of DYT1 dystonia, but it is poorly tolerated due to significant side effects.
Anthony M. Downs, Xueliang Fan, Christine Donsante, H.A. Jinnah, Ellen J. Hess   +4 more
doaj   +1 more source

Nicotine addiction : a review [PDF]

, 2013
Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core   +1 more source

Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors

Frontiers in Cellular Neuroscience, 2015
Prefrontal layer 6 (L6) pyramidal neurons play an important role in the adult control of attention, facilitated by their strong activation by nicotinic acetylcholine receptors.
Lily eKang, Michael K Tian, Craig D. C. Bailey, Craig D. C. Bailey, Evelyn K Lambe, Evelyn K Lambe, Evelyn K Lambe   +6 more
doaj   +1 more source

Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions

Pharmacological Research, 2023
Initiated by findings that Alzheimer’s disease is associated with a profound loss of cholinergic markers in human brain, decades of studies have examined the interactions between specific subtypes of nicotinic acetylcholine receptors and amyloid-β ...
Paul Whiteaker, Andrew A. George
doaj   +1 more source

Nicotinic potentiation of frog retinotectal transmission in tectum layer F by α3β2, α4β2, α2β4, α6β2, or α7 acetylcholine receptor subtypes

Medicina, 2015
Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas, Vilija Kuraitė, Antanas Kuras   +2 more
doaj   +1 more source