Results 41 to 50 of about 46,003 (163)

Nicotine dependence and genetic variation in the nicotinic receptors [PDF]

Drug and Alcohol Dependence, 2009
Technological advances have led to the discovery of genetic variants that contribute to many illnesses including nicotine dependence. A multi-stage model of the development of nicotine dependence underlies these genetic studies, and it includes a progression through several stages of smoking behavior from never smoking to nicotine dependence. The final
openaire   +2 more sources

Systemic injection of nicotinic acetylcholine receptor antagonist mecamylamine affects licking, eyelid size, and locomotor and autonomic activities but not temporal prediction in male mice

Molecular Brain, 2022
Nicotinic acetylcholine receptors are thought to be associated with a wide range of phenomena, such as movement, learning, memory, attention, and addiction. However, the causal relationship between nicotinic receptor activity and behavior remains unclear.
Shohei Kaneko, Yasuyuki Niki, Kota Yamada, Daiki Nasukawa, Yusuke Ujihara, Koji Toda   +5 more
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Nicotinic Receptor Function in Schizophrenia [PDF]

Schizophrenia Bulletin, 1996
Schizophrenia can be partially characterized by deficits in sensory processing. Biochemical, molecular, and genetic studies of one such endophenotype, the P50 auditory-evoked potential gating deficit, suggest that one of the neuronal nicotinic receptors, the alpha 7 nicotinic receptor, may function in an inhibitory neuronal pathway involved in this ...
S, Leonard, C, Adams, C R, Breese, L E, Adler, P, Bickford, W, Byerley, H, Coon, J M, Griffith, C, Miller, M, Myles-Worsley, H T, Nagamoto, Y, Rollins, K E, Stevens, M, Waldo, R, Freedman   +14 more
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Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain

Substance Abuse: Research and Treatment, 2008
Nicotine, the addictive component of cigarette smoke has profound effects on the brain. Activation of its receptors by nicotine has complex consequences for network activity throughout the brain, potentially contributing to the addictive property of the ...
Geeta Sharma, Sukumar Vijayaraghavan
doaj   +2 more sources

Toxic Effect of Cigarette Smoke on Brainstem Nicotinic Receptor Expression: Primary Cause of Sudden Unexplained Perinatal Death

Toxics, 2018
Among the neurotoxicants contained in tobacco smoke, if absorbed during pregnancy, nicotine significantly affects α7-nicotinic acetylcholine receptors, which play essential roles in the development of the brainstem regions receiving cholinergic ...
Anna Maria Lavezzi
doaj   +1 more source

Nicotine Addiction: Neurobiology and Mechanism

Journal of Pharmacopuncture, 2020
Nicotine, primary component of tobaco produces craving and withdrawal effect both in humans and animals. Nicotine shows a close resemblance to other addictive drugs in molecular, neuroanatomical and pharmacological, particularly the drugs which enhances ...
Raj Kumar Tiwari, Vikas Sharma, Ravindra Kumar Pandey, Shiv Shankar Shukla   +3 more
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Interaction of Dorsal Hippocampal Nicotinic Receptors and Zinc Oxide Nanoparticles on Memory Consolidation [PDF]

Pharmaceutical and Biomedical Research
Background: Zinc oxide nanoparticles (ZnO NPs) are widely used in industry, medicine, and agriculture. Previous studies have shown that exposure to ZnO NPs can induce changes in learning and memory.
Niloufar Darbandi, Ahmad Sadeghi, Farzaneh Nazari-Serenjeh, Zahra Ghasemzadeh   +3 more
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Evaluation of the cholinomimetic actions of trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana (Gastropoda, Opisthobranchia)

Brazilian Journal of Medical and Biological Research, 2002
Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable ability to inhibit cholinergic responses.
C.M. Kerchove, R.P. Markus, J.C. Freitas, L.V. Costa-Lotufo   +3 more
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Nicotinic Receptor Activity Alters Synaptic Plasticity

The Scientific World Journal, 2001
Studies using specific agonists, antagonists, and lesions have shown that nicotinic cholinergic systems participate in attention, learning, and memory[1,2].
John A. Dani
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Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails

Marine Drugs, 2018
Marine cone snails are a large family of gastropods that have evolved highly potent venoms for predation and defense. The cone snail venom has exceptional molecular diversity in neuropharmacologically active compounds, targeting a range of receptors, ion
Nikita Abraham, Richard J. Lewis
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