Results 61 to 70 of about 91,068 (205)

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders [PDF]

, 2013
Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders.
Akagbosu, Akladios, Alexander, Alkondon, Alkondon, Alkondon, Amori, Andersen, Atlas, Autier, Backman, Beal, Benatti, Bonda, Breese, Carpenedo, Carpenedo, Casazza, Castellano, Ceresoli-Borroni, Cesura, Chess, Chess, Chess, Chiarugi, Chiarugi, Clark, Cochran, Cozzi, Cui, Daily, Dalley, Dantzer, Darlington, Darlington, Davidson, Deiana, Della Torre, DiNatale, Dobelis, Dounay, Eastman, Erhardt, Forrest, Forrest, Forrest, Forrest, Fukui, Gellert, Giordani, Giorgini, Gold, Graef, Guidetti, Guidetti, Guidetti, Guidetti, Guillemin, Guillemin, Hardingham, Hedges, Henderson, Heng, Hernandez, Heyes, Hilmas, Holtze, Jason, Jauch, Jentsch, Jurgens, Kalisch, Kandanearatchi, Kiank, Kihara, Kloet, Kocki, Konradsson-Geuken, Lawrence, Lawrence, Linderholm, Lindsley, Luchowski, Luchowski, Lupien, Marin, Mexal, Millan, Miller, Minzenberg, Miura, Moeller, Mok, Muchowski, Muchowski, Mueller, Muscatell, Myint, Nagy, Neill, Newcomer, Newcomer, Nilsson, Nilsson, Nozaki, O'Connor, Olsson, Onur, Owe-Young, Paterson, Pearson, Pechtel, Pellicciari, Pellicciari, Perkins, Pertovaara, Pevarello, Phillips, Pocivavsek, Pocivavsek, Popoli, Popoli, Potter, Rahman, Raison, Rassoulpour, Ren, Robert, Rodgers, Rossi, Ryu, Röver, Saito, Salazar, Sapko, Sarter, Sathyasaikumar, Sathyasaikumar, Schwarcz, Schwarcz, Schwarcz, Schwarcz, Shear, Speciale, Speciale, Stazka, Stazka, Stone, Stone, Stone, Stone, Stone, Stoy, Tadaiesky, Tatter, Teichberg, Teichberg, Ting, Trecartin, Tse, Varasi, Vezzani, Walker, Wang, Wang, Wejksza, Wejksza, Wonodi, Xu, Yamada, Yuen, Zisapel, Zmarowski   +172 more
core   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

Loop B is a major structural component of the 5-HT3 receptor [PDF]

, 2008
The 5-HT3 receptor belongs to a family of therapeutically important neurotransmitter-gated receptors whose ligand binding sites are formed by the convergence of six peptide loops (A-F).
Thompson, Andrew J., Lochner, Martin, Lummis, S. C. R.   +2 more
core   +2 more sources

Nicotinic Receptor Antagonists as Treatments for Nicotine Abuse [PDF]

, 2014
Despite the proven efficacy of current pharmacotherapies for tobacco dependence, relapse rates continue to be high, indicating that novel medications are needed. Currently, several smoking cessation agents are available, including varenicline (Chantix®), bupropion (Zyban®), and cytisine (Tabex®).
Peter A, Crooks, Michael T, Bardo, Linda P, Dwoskin   +2 more
openaire   +2 more sources

Systemic injection of nicotinic acetylcholine receptor antagonist mecamylamine affects licking, eyelid size, and locomotor and autonomic activities but not temporal prediction in male mice

Molecular Brain, 2022
Nicotinic acetylcholine receptors are thought to be associated with a wide range of phenomena, such as movement, learning, memory, attention, and addiction. However, the causal relationship between nicotinic receptor activity and behavior remains unclear.
Shohei Kaneko, Yasuyuki Niki, Kota Yamada, Daiki Nasukawa, Yusuke Ujihara, Koji Toda   +5 more
doaj   +1 more source

Nicotinic Receptor Function in Schizophrenia [PDF]

Schizophrenia Bulletin, 1996
Schizophrenia can be partially characterized by deficits in sensory processing. Biochemical, molecular, and genetic studies of one such endophenotype, the P50 auditory-evoked potential gating deficit, suggest that one of the neuronal nicotinic receptors, the alpha 7 nicotinic receptor, may function in an inhibitory neuronal pathway involved in this ...
S, Leonard, C, Adams, C R, Breese, L E, Adler, P, Bickford, W, Byerley, H, Coon, J M, Griffith, C, Miller, M, Myles-Worsley, H T, Nagamoto, Y, Rollins, K E, Stevens, M, Waldo, R, Freedman   +14 more
openaire   +2 more sources

Toxic Effect of Cigarette Smoke on Brainstem Nicotinic Receptor Expression: Primary Cause of Sudden Unexplained Perinatal Death

Toxics, 2018
Among the neurotoxicants contained in tobacco smoke, if absorbed during pregnancy, nicotine significantly affects α7-nicotinic acetylcholine receptors, which play essential roles in the development of the brainstem regions receiving cholinergic ...
Anna Maria Lavezzi
doaj   +1 more source

Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region [PDF]

, 1992
Tris+/Na+ permeability ratios were measured from shifts in the biionic reversal potentials of the macroscopic ACh-induced currents for 3 wild- type (WT), 1 hybrid, 2 subunit-deficient, and 25 mutant nicotinic receptors expressed in Xenopus oocytes.
Cohen, Bruce N., Czyzyk, Linda, Davidson, Norman, Labarca, Cesar, Lester, Henry A.   +4 more
core   +2 more sources

Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain

Substance Abuse: Research and Treatment, 2008
Nicotine, the addictive component of cigarette smoke has profound effects on the brain. Activation of its receptors by nicotine has complex consequences for network activity throughout the brain, potentially contributing to the addictive property of the ...
Geeta Sharma, Sukumar Vijayaraghavan
doaj   +2 more sources

Nicotine Addiction: Neurobiology and Mechanism

Journal of Pharmacopuncture, 2020
Nicotine, primary component of tobaco produces craving and withdrawal effect both in humans and animals. Nicotine shows a close resemblance to other addictive drugs in molecular, neuroanatomical and pharmacological, particularly the drugs which enhances ...
Raj Kumar Tiwari, Vikas Sharma, Ravindra Kumar Pandey, Shiv Shankar Shukla   +3 more
doaj   +1 more source