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Review: Nicotinic receptors and stages of nicotine dependence
Journal of Psychopharmacology, 2009Smoking is one of the leading causes of preventable death, where nicotine has been identified as the primary addictive constituent of tobacco. Consequently, there have been extensive investigations into the neuroadaptations that occur as nicotine dependence develops, where numerous neurological systems have been implicated. The focus of this review was
Rodney A. Lea +3 more
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Annual Review of Pharmacology and Toxicology, 2007
Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from numerous subunit combinations that compose channel-receptor complexes with varied functional and pharmacological characteristics. Structural and functional diversity and
J. Dani, D. Bertrand
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Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from numerous subunit combinations that compose channel-receptor complexes with varied functional and pharmacological characteristics. Structural and functional diversity and
J. Dani, D. Bertrand
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Nicotine and Nicotinic Receptor Involvement in Neuropsychiatric Disorders
Current Topics in Medicinal Chemistry, 2004Advances in the understanding of the neurobiology of the nicotinic receptor have started to be matched by an appreciation of the potential role of these receptors in a variety of neuropsychiatric disorders. While alterations in nicotinic receptor number and/or function have been associated with such conditions as Alzheimer's disease for several years ...
Alexandra Potter +2 more
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Nicotine and Nicotinic Receptors; Relevance to Parkinson’s Disease
NeuroToxicology, 2002The development of nicotinic agonists for therapy in neurodegenerative disorders such as Parkinson's disease is an area currently receiving considerable attention. The rationale for such work stems from findings that reveal a loss of nicotinic receptors in Parkinson's disease brains.
Maryka Quik, Jennifer M. Kulak
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Nicotine, Brain Nicotinic Receptors, and Neuropsychiatric Disorders
Archives of Medical Research, 2000Neuronal nicotinic acetylcholine receptors (nAChRs) represent a large family of ligand-gated cation channels with diverse structures and properties. In contrast to the muscular nAChRs, the physiological functions of neuronal nAChRs are not well defined to date.
René Drucker-Colín, Stefan Mihailescu
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Effect of nicotine and nicotinic receptors on anxiety and depression
Neuroreport, 2002Nicotine has been shown to have effects on anxiety and depression in both human and animal studies. These studies suggest that nicotinic acetylcholine receptors (nAChRs) can modulate the function of pathways involved in stress response, anxiety and depression in the normal brain, and that smoking can result in alterations of anxiety level and mood. The
Barbara J. Caldarone +2 more
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Structure of Neuronal Nicotinic Receptors
2015Nicotinic acetylcholine receptors (nAChRs) are a critical component of the brain's cholinergic neurotransmission system that modulates important physiological processes and whose dysfunction has been observed in patients with neurodegenerative diseases and mental illness.
Fasoli F, Gotti C
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α7-Nicotinic receptors and cognition.
Current Drug Targets, 2012Nicotinic α7 receptors have been shown in a variety of studies with animal models to play important roles in diverse components of cognitive function, including learning, memory and attention.
E. Levin
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Nicotinic Acetylcholine Receptors
2003Publisher Summary This chapter deals with nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels
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Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons.
Annual Review of Physiology, 1995The last decade has revealed an astounding degree of physiological and st ruct ural divers it y in neurot ransmitteract ivated receptors. In part icular, mo lecular st udies of the acet ylcholine-gated recept ors in vert ebrate muscle cells and Torpedo ...
D. McGehee, L. Role
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