Results 291 to 300 of about 2,466,892 (329)

Nicotinic receptors and Parkinson's disease

European Journal of Pharmacology, 2000
Accumulating evidence indicates that nicotinic receptors play a role in basal ganglia function. Furthermore, nicotine administration may be neuroprotective in animal models of nigrostriatal degeneration, while cigarette smoking is inversely correlated with Parkinson's disease.
M, Quik, G, Jeyarasasingam
openaire   +2 more sources

Human neuronal nicotinic receptors

Progress in Neurobiology, 1997
Nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative, behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine receptors (NAChRs). These receptors are distributed widely in human brain and ganglia, and form a family of ACh-gated ion channels of different subtypes, each of which has a ...
C. Gotti, D. Fornasari, F. Clementi
openaire   +3 more sources

The paradox of nicotinic acetylcholine receptor upregulation by nicotine

Trends in Pharmacological Sciences, 1990
Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
openaire   +2 more sources

Nicotine receptor mapping

European Journal of Nuclear Medicine, 1996
F, Grünwald, H J, Biersack, W, Kuschinsky   +2 more
openaire   +2 more sources

Nicotinic Receptors

2006
D Bertrand, R Hogg
  +5 more sources

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Nature, 2001
Katjua Brejc, W. Dijk, R. Klaassen, M. Schuurmans, J. Oost, A. Smit, T. Sixma   +6 more
semanticscholar   +1 more source

Nicotinic receptors and stages of nicotine dependence.

Journal of psychopharmacology (Oxford, England), 2010
Smoking is one of the leading causes of preventable death, where nicotine has been identified as the primary addictive constituent of tobacco. Consequently, there have been extensive investigations into the neuroadaptations that occur as nicotine dependence develops, where numerous neurological systems have been implicated. The focus of this review was
K A, Brennan, R A, Lea, P S, Fitzmaurice, P, Truman   +3 more
openaire   +1 more source

Multiple Nicotinic Receptors: Nicotinic Ligands with Different Specificities

, 1987
J. Sloan, W. Martin, Walter T. Smith
semanticscholar   +1 more source

Allosteric modulation of nicotinic acetylcholine receptors.

Biochemical Pharmacology, 2015
Anna Chatzidaki, N. Millar
semanticscholar   +1 more source

Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system.

Annual Review of Pharmacology and Toxicology, 2007
J. Dani, D. Bertrand
semanticscholar   +1 more source