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Human neuronal nicotinic receptors
Progress in Neurobiology, 1997Nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative, behavioural and psychological effects by interacting with neuronal nicotinic acetylcholine receptors (NAChRs). These receptors are distributed widely in human brain and ganglia, and form a family of ACh-gated ion channels of different subtypes, each of which has a ...
C. Gotti, D. Fornasari, F. Clementi
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Annual Review of Entomology, 2003
Neonicotinoids, the most important new class of synthetic insecticides of the past three decades, are used to control sucking insects both on plants and on companion animals.
M. Tomizawa, J. Casida
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Neonicotinoids, the most important new class of synthetic insecticides of the past three decades, are used to control sucking insects both on plants and on companion animals.
M. Tomizawa, J. Casida
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Nicotinic Receptors and Attention
2015Facilitation of different attentional functions by nicotinic acetylcholine receptor (nAChR) agonists may be of therapeutic potential in disease conditions such as Alzheimer's disease or schizophrenia. For this reason, the neuronal mechanisms underlying these effects have been the focus of research in humans and in preclinical models.
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Nicotinic receptors in wonderland
Trends in Biochemical Sciences, 2001Abstract The structure of a soluble homopentameric homologue of the N-terminal extracellular domain of the nicotinic acetylcholine (ACh) receptor has recently been determined at the atomic level. These data reveal the three-dimensional structure of the binding site for ACh and nicotinic ligands.
Jean-Pierre Changeux, Thomas Grutter
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The paradox of nicotinic acetylcholine receptor upregulation by nicotine
Trends in Pharmacological Sciences, 1990Abstract Chronic exposure to agonist (or conditions that increase the synaptic concentration of the natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation of the target receptor. Conversely, chronic exposure to antagonist (or conditions that decrease the synaptic concentration of transmitter, including ...
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2012
Publisher Summary This chapter focuses on the structural considerations and subtype diversity of nicotinic receptors. Nicotinic receptors assemble as pentamers of individual subunits. Assembly occurs in a precise manner and order such that the assembled subunits encircle an internal membrane pore and the extracellular vestibule leading to the pore ...
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Publisher Summary This chapter focuses on the structural considerations and subtype diversity of nicotinic receptors. Nicotinic receptors assemble as pentamers of individual subunits. Assembly occurs in a precise manner and order such that the assembled subunits encircle an internal membrane pore and the extracellular vestibule leading to the pore ...
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Nicotinic receptors and Parkinson's disease
European Journal of Pharmacology, 2000Accumulating evidence indicates that nicotinic receptors play a role in basal ganglia function. Furthermore, nicotine administration may be neuroprotective in animal models of nigrostriatal degeneration, while cigarette smoking is inversely correlated with Parkinson's disease.
Maryka Quik, Gayathri Jeyarasasingam
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The Nicotinic Acetylcholine Receptor
1985The acetylcholine receptor (AcChR) from Torpedo electroplax has been isolated both in its native membrane-bound state and by affinity chromatography after solubilization (see Conti-Tronconi and Raftery, 1982). Purified membrane fragments can reseal, forming closed, right-side-out vesicles, which can be used for both functional and structural studies ...
Michael A. Raftery +4 more
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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
Nature, 2001Katjua Brejc +6 more
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