Results 201 to 210 of about 25,455 (216)

A review of the kappa opioid receptor system in opioid use

Neuroscience & Biobehavioral Reviews
The kappa opioid receptor (KOR) system is implicated in dysphoria and as an "anti-reward system" during withdrawal from opioids. However, no clear consensus has been made in the field, as mixed findings have been reported regarding the relationship between the KOR system and opioid use.
Salih Cayir, Simon Zhornitsky, Alireza Barzegary, Esteban Sotomayor-Carreño, Wonder Sarfo-Ansah, Melissa C. Funaro, David Matuskey, Gustavo Angarita   +7 more
openaire   +2 more sources

Kappa-opioid receptors and analgesia.

Trends in pharmacological sciences, 1990
Over the past decade, opioids have attracted great attention. One important reason for this is the need for novel, strong analgesics free of the abuse potential and side-effects of narcotics such as morphine. Because morphine acts at mu-opioid receptors, efforts have been made to characterize analgesia mediated by non-mu sites, in particular kappa ...
openaire   +1 more source

Kappa opioid receptors as modulators of novelty processing

Neuropsychopharmacology, 2023
Kathryn Braden, Daniel C. Castro
openaire   +2 more sources

PHARMACOKINETICS INVOLVED WITH KAPPA OPIOID RECEPTORS

International Journal of Health Science, 2022
Natan Augusto de Almeida Santana, Alexandre Augusto de Andrade Santana, Ana Karla Aguiar de Oliveira Lopes, Bernardo Malheiros Tessari, Bruna Costa Alves, Gustavo Rodrigues Póvoa, Isabela de Paula Sá, Lara Pedriel Barreto, Natália Ribeiro Silvério, Sérgio Gabriell de Oliveira Moura, Yuri Borges Bitu de Freitas, Luciano Alves Matias da Silveira   +11 more
openaire   +1 more source

Selective non-peptide kappa opioid receptor agonists

Expert Opinion on Investigational Drugs, 1994
This article provides an overview of the development of selective K-opioid receptor antagonists as potential analgesics and neuroprotective agents. An important milestone in defining the properties of a K-receptor agonist was the discovery of the N-(2-aminocyclo-hexyl)arylacetamide class of selective K-receptor agonist, of which U-50488 was the ...
openaire   +1 more source

Medicinal Chemistry of Kappa Opioid Receptor Antagonists

2009
The kappa opioid receptor (KOR), a member of the opioid receptor family, was initially studied for its involvement in the mediation of pain. More recently, there has been growing interest in selective KOR agents for their potential effects on mood and reward.
Cécile Béguin, Bruce M. Cohen
openaire   +1 more source

Molecular modeling on kappa opioid receptor and its interaction with nonpeptide kappa opioid agonists.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999
To study the interaction between kappa-opioid receptor and its nonpeptide agonists.The "conservation patterns" for G-protein coupled receptors (GPCR) were used to determine 7 transmembrane (TM) regions. Taking the crystallographic coordinates of bacteriorhodopsin (BR) as the template, the 3D structural model was constructed for 7 TM of kappa-opioid ...
D X, Liu, H L, Jiang, J S, Shen, W L, Zhu, L, Zhao, K X, Chen, R Y, Ji   +6 more
openaire   +1 more source

Psychotomimetic Effects of Kappa Opioid Receptor Agonists

Biological Psychiatry, 2012
Kate L, White, Bryan L, Roth
openaire   +2 more sources

[Kappa-opioid receptor: molecular structure and function].

Eksperimental'naia i klinicheskaia farmakologiia, 2015
It is eastablished that kappa-opioid receptors have complicated structure. These receptors may play the important role in different processes in CNS.
A A, Spasov, O Iu, Grechko, D M, Shtareva   +2 more
openaire   +1 more source

Kappa Opioid Receptor

2007
Fabien Decaillot, Jose Moron, Noura S. Abul-Husn, Lakshmi Devi   +3 more
openaire   +1 more source