Results 271 to 280 of about 2,381,066 (350)

On‐Resin Pictet–Spengler Cyclization for 1,2,3,4‐Tetrahydro‐β‐carboline‐3‐carboxylate (Tcc) Peptide Synthesis With Acid‐Labile Functional Tolerance

open access: yesJournal of Peptide Science, Volume 32, Issue 2, February 2026.
The constrained tryptophan (Trp) analog 1,2,3,4‐tetrahydro‐β‐carboline‐3‐carboxylic acid (Tcc) is used to restrict peptide conformation in structure–activity relationship studies. Although Pictet–Spengler cyclization of Trp and aldehydes with mineral acid gives Tcc analogs, such harsh conditions do not tolerate acid‐labile functionality.
Omer S. L. N'dri   +10 more
wiley   +1 more source

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

open access: yesSmall, Volume 22, Issue 8, 6 February 2026.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad   +11 more
wiley   +1 more source

Revisiting the Value of Admission Cardiotocography in Term Pregnancies: An Updated Systematic Review and Meta‐Analysis

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 3, Page 375-390, February 2026.
ABSTRACT Background Admission cardiotocography (CTG) remains widely used to assess the fetal condition at the onset of labour in low‐risk pregnancies, despite international guidelines recommending against its routine use and advocating intermittent auscultation (IA) instead.
Mariana Tome   +4 more
wiley   +1 more source

Oxytocin, Epigenetic Aging, and the Social Regulation of Health: A Lifecourse Perspective on the Maejima et al. Findings

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
The elegant work by Maejima et al. (Aging Cell, 2025) reveals a previously unrecognized mechanism linking age‐related oxytocin (OXT) decline to epigenetic remodeling, mitochondrial dysfunction, and systemic inflammation, reversible through exogenous OXT administration.
Kerstin Uvnäs‐Moberg   +3 more
wiley   +1 more source

The extracellular vesicles of boar seminal plasma contain oxytocin at levels associated with fertility. [PDF]

open access: yesExtracell Vesicles Circ Nucl Acids
Parra A   +6 more
europepmc   +1 more source

Twenty‐year trends in fetal scalp‐blood sampling and birth outcomes: A single‐center retrospective cohort study of 40 309 women in labor

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 2, Page 346-355, February 2026.
Obstetric and early neonatal outcomes and intrapartum fetal blood sampling among 40 309 singleton women undergoing trial of labor by 5‐year periods from 2002 to 2021 at Kuopio University Hospital. Among women undergoing a trial of labor, the use of fetal blood sampling (FBS) steadily declined from 11.7% to 3.7%.
Saana Pietilä   +3 more
wiley   +1 more source

Primary Dysmenorrhea Induced Using Diethylstilbestrol and Oxytocin Induces Impaired Uterine Reactivity in Virgin Female Wistar Rats. [PDF]

open access: yesPharmaceuticals (Basel)
Lacerda-Júnior FF   +8 more
europepmc   +1 more source

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