Results 1 to 10 of about 22,717 (253)

Characterization and Expression of Oxytocin and the Oxytocin Receptor

Molecular Genetics and Metabolism, 2000
Oxytocin, a nonapeptide hormone and neurotransmitter, is expressed in a variety of tissues, as are its receptors. In vivo, oxytocin acts as a paracrine and/or autocrine mediator of multiple biological effects. These effects are exerted primarily through interactions with G-protein-coupled oxytocin/vasopressin receptors, which, via G(q) and G(i ...
Hideki Shojo
exaly   +3 more sources

Cholesterol as stabilizer of the oxytocin receptor

Biochimica Et Biophysica Acta - Biomembranes, 2002
The function of the oxytocin receptor system is strongly dependent on steroids as demonstrated by several physiological studies. One key element of this dependence on steroids may be the interaction of cholesterol and the oxytocin receptor. In this study, we show that cholesterol stabilizes the solubilized human oxytocin receptor against thermal ...
Gerald Gimpl, Falk Fahrenholz
exaly   +3 more sources

DNA methylation of specific CpG sites in the promoter region regulates the transcription of the mouse oxytocin receptor. [PDF]

PLoS ONE, 2013
Oxytocin is a peptide hormone, well known for its role in labor and suckling, and most recently for its involvement in mammalian social behavior. All central and peripheral actions of oxytocin are mediated through the oxytocin receptor, which is the ...
Shimrat Mamrut, Hala Harony, Rapita Sood, Hadar Shahar-Gold, Harold Gainer, Yi-Jun Shi, Liza Barki-Harrington, Shlomo Wagner   +7 more
doaj   +1 more source

Transactivation of TrkB Receptors by Oxytocin and Its G Protein-Coupled Receptor

Frontiers in Molecular Neuroscience, 2022
Brain-derived Neurotrophic Factor (BDNF) binds to the TrkB tyrosine kinase receptor, which dictates the sensitivity of neurons to BDNF. A unique feature of TrkB is the ability to be activated by small molecules in a process called transactivation.
Mariela Mitre, Mariela Mitre, Mariela Mitre, Mariela Mitre, Mariela Mitre, Mariela Mitre, Khalil Saadipour, Kevin Williams, Latika Khatri, Robert C. Froemke, Robert C. Froemke, Robert C. Froemke, Robert C. Froemke, Robert C. Froemke, Moses V. Chao, Moses V. Chao, Moses V. Chao, Moses V. Chao, Moses V. Chao   +18 more
doaj   +1 more source

17β-estradiol upregulates oxytocin and the oxytocin receptor in C2C12 myotubes [PDF]

PeerJ, 2017
Background The endocrinology of skeletal muscle is highly complex and many issues about hormone action in skeletal muscle are still unresolved. Aim of the work is to improve our knowledge on the relationship between skeletal muscle and 17β-estradiol ...
Enrica Berio, Sara Divari, Laura Starvaggi Cucuzza, Bartolomeo Biolatti, Francesca Tiziana Cannizzo   +4 more
doaj   +2 more sources

An overview of the oxytocin-oxytocin receptor signaling network [PDF]

Journal of Cell Communication and Signaling, 2016
Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the hypothalamus and stored and released from the neural lobe of the pituitary gland. Although commonly known for its central role in the regulation of parturition and lactation, oxytocin signaling also plays a key role in modulating social behavior, evoking contentment ...
Oishi, Chatterjee, Krutika, Patil, Apeksha, Sahu, Lathika, Gopalakrishnan, Praseeda, Mol, Jayshree, Advani, Srabani, Mukherjee, Rita, Christopher, T S Keshava, Prasad   +8 more
openaire   +2 more sources

Immunoglobulin G is a natural oxytocin carrier which modulates oxytocin receptor signaling: relevance to aggressive behavior in humans

Discover Mental Health, 2023
Oxytocin is a neuropeptide produced mainly in the hypothalamus and secreted in the CNS and blood. In the brain, it plays a major role in promoting social interactions.
Henning Værøy, Emilie Lahaye, Christophe Dubessy, Magalie Benard, Marion Nicol, Yamina Cherifi, Saloua Takhlidjt, Jean-Luc do Rego, Jean-Claude do Rego, Nicolas Chartrel, Sergueï O. Fetissov   +10 more
doaj   +1 more source

Lack of Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Alexithymia: Evidence from Patients with Obsessive-Compulsive Disorder. [PDF]

PLoS ONE, 2015
Oxytocin receptor gene single nucleotide polymorphisms have been associated with structural and functional alterations in brain regions, which involve social-emotional processing.
Min Jung Koh, Wonji Kim, Jee In Kang, Kee Namkoong, Se Joo Kim   +4 more
doaj   +1 more source

Involvement of central opiate receptors in modulation of centrally administered oxytocin-induced antinociception [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Oxytocin is involved in modulation of many brain-mediated functions. In the present study, we investigated the central effects of oxytocin and its receptor antagonist, atosiban on inflammatory pain.
Amir Erfanparast, Esmaeal Tamaddonfard, Sahar Seyedin   +2 more
doaj   +1 more source

Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1

Cell Reports, 2017
Summary: Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which ...
Yelena Nersesyan, Lusine Demirkhanyan, Deny Cabezas-Bratesco, Victoria Oakes, Ricardo Kusuda, Tyler Dawson, Xiaohui Sun, Chike Cao, Alejandro Martin Cohen, Bharath Chelluboina, Krishna Kumar Veeravalli, Katharina Zimmermann, Carmen Domene, Sebastian Brauchi, Eleonora Zakharian   +14 more
doaj   +1 more source