Results 41 to 50 of about 22,072 (167)

Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking

Translational Psychiatry, 2022
As opioid-related fatalities continue to rise, the need for novel opioid use disorder (OUD) treatments could not be more urgent. Two separate hypothalamic neuropeptide systems have shown promise in preclinical OUD models. The oxytocin system, originating
Giuseppe Giannotti, Francesca Mottarlini, Jasper A. Heinsbroek, Mitchel R. Mandel, Morgan H. James, Jamie Peters   +5 more
doaj   +1 more source

Chronic oxytocin administration stimulates the oxytocinergic system in children with autism

Nature Communications
Clinical efficacy of intranasal administration of oxytocin is increasingly explored in autism spectrum disorder, but to date, the biological effects of chronic administration regimes on endogenous oxytocinergic function are largely unknown.
Matthijs Moerkerke, Nicky Daniels, Laura Tibermont, Tiffany Tang, Margaux Evenepoel, Stephanie Van der Donck, Edward Debbaut, Jellina Prinsen, Viktoria Chubar, Stephan Claes, Bart Vanaudenaerde, Lynn Willems, Jean Steyaert, Bart Boets, Kaat Alaerts   +14 more
doaj   +1 more source

New Topics in Vasopressin Receptors and Approach to Novel Drugs: Vasopressin and Pain Perception

Journal of Pharmacological Sciences, 2009
Arginine vasopressin (AVP) activates three vasopressin receptors and it also has an agonistic activity on the oxytocin receptor. For an accurate description of the target receptor subtype(s) responsible for complex AVP and oxytocin actions, a careful ...
Taka-aki Koshimizu, Gozoh Tsujimoto
doaj   +1 more source

Development of Magnetic Nanobeads Modified by Artificial Fluorescent Peptides for the Highly Sensitive and Selective Analysis of Oxytocin

Sensors, 2020
We describe two novel fluorescent peptides (compounds 1 and 2) targeting oxytocin with a boron-dipyrromethenyl group as the fluorophore bound to an artificial peptide based on the oxytocin receptor, and their application for the analysis of oxytocin ...
Yoshio Suzuki
doaj   +1 more source

Oxytocin restores cognitive function and attenuates neuroinflammation in chronic sleep-deprived aged rats

Frontiers in Aging Neuroscience
BackgroundSleep is a fundamental biological process essential for maintaining mental, emotional, and physical health. Chronic sleep deprivation (SD), particularly in aging, is associated with oxidative stress, neuroinflammation, apoptosis, and cognitive ...
Hany A. Elkattawy, Mohamed El-Sherbiny, Nehal Elsherbiny, Reham M. Wahid, Sherein F. El-Sayed, Hanan A. Henidi, Randa El-Gamal, Randa El-Gamal, Sultan Alshehri, Syed Mohammed Basheeruddin Asdaq, Syed Mohammed Basheeruddin Asdaq   +10 more
doaj   +1 more source

Characterization of oxytocin and vasopressin receptors in the Southern giant pouched rat and comparison to other rodents

Frontiers in Endocrinology
Vasopressin and oxytocin are well known and evolutionarily ancient modulators of social behavior. The distribution and relative densities of vasopressin and oxytocin receptors are known to modulate the sensitivity to these signaling molecules ...
Angela R. Freeman, Angela R. Freeman, Samanta Arenas, Danielle N. Lee, Danielle N. Lee, Bhupinder Singh, Bhupinder Singh, Alexander G. Ophir   +7 more
doaj   +1 more source

Oxytocin receptor is regulated by Peg3

PLOS ONE, 2018
Mouse Peg3 encodes a DNA-binding protein involved in the milk letdown process. In the current study, we tested whether PEG3 controls the expression of the oxytocin receptor gene. According to the results, PEG3 directly binds to a genomic region within the 3rd exon of Oxtr, which contains a DNA-binding motif for PEG3.
Wesley D. Frey, Kaustubh Sharma, Terri L. Cain, Katsuhiko Nishimori, Ryoichi Teruyama, Joomyeong Kim   +5 more
openaire   +4 more sources

Life in groups: the roles of oxytocin in mammalian sociality

Frontiers in Behavioral Neuroscience, 2013
In recent decades, scientific understanding of the many roles of oxytocin in social behavior has advanced tremendously. The focus of this research has been on maternal attachments and reproductive pair-bonds, and much less is known about the substrates ...
Allison eAnacker, Annaliese eBeery, Annaliese eBeery   +2 more
doaj   +1 more source

Oxytocin Protects Nigrostriatal Dopamine Signal via Activating GABAergic Circuit in the MPTP‐Induced Parkinson's Disease Model

Advanced Science
The most pronounced neuropathological feature of Parkinson's disease (PD) is the loss of dopamine (DA) neurons in the substantia nigra compacta (SNc), which depletes striatal DA.
Yurong Wang, Hao Xu, Saiyong Chen, Junhao Chen, Qimeng Zheng, Yuanyuan Ma, Xinru Zhao, Ying Shi, Lei Xiao   +8 more
doaj   +1 more source

Oxytocin: recent developments

Biomolecular Concepts, 2010
Oxytocin is a neurohypophyseal hormone that is produced centrally by neurons in the paraventricular nucleus and supraoptic nucleus of the hypothalamus.
Tom Nicole C., Assinder Stephen J.
doaj   +1 more source