Results 121 to 130 of about 4,287,179 (359)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins [PDF]

, 2017
Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation.
Cavalcanti-Adam, Elisabetta Ada, Geiger, Benjamin, Kapp, Tobias G., Kessler, Horst, Maltsev, Oleg V., Mas Moruno, Carlos, Neubauer, Stefanie, Notni, Johannes, Rechenmacher, Florian, Reuning, Ute, Spatz, Joachim, Wester, Hans-Jürgen, Zarka, Revital   +12 more
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma. [PDF]

, 2018
The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients has resulted in considerable excitement in ...
Akerman, Simon, Baca, Serapio M, Waschek, James A   +2 more
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes [PDF]

, 2009
Cell membranes interact via anchored receptor and ligand molecules. Central questions on cell adhesion concern the binding affinity of these membrane-anchored molecules, the mechanisms leading to the receptor-ligand domains observed during adhesion, and ...
Albersdörfer, Alon, Arnold, Asfaw, Auth, Baksh, Bartosz Różycki, Bayas, Bell, Bell, Bershadsky, Bruinsma, Bunnell, Burroughs, Campi, Chen, Chen, Chesla, Choudhuri, Coombs, Davis, Davis, De, Delanoe-Ayari, DeMond, Discher, Dustin, Dustin, Dustin, Dustin, Dustin, Dustin, El Alaoui Faris, Figge, Fournier, Geiger, Girard, Goetz, Gov, Gov, Gov, Grakoui, Gruhn, Heinrich Krobath, Helfrich, Hu, Huang, Ichimura, Irvine, Jeppesen, Kim, Kloboucek, Komura, Krobath, Krogsgaard, Leckband, Lee, Lin, Lin, Lipowsky, Lipowsky, Lorz, Maier, Manneville, Martin, McDonnell, Mesfin Asfaw, Monks, Moore, Moreira, Mossman, Möller, Orsello, Prost, Purbhoo, Purrucker, Qi, Ramaswamy, Raychaudhuri, Reinhard Lipowsky, Reister-Gottfried, Rich, Różycki, Różycki, Różycki, Różycki, Sabra, Sako, Schuck, Schwarz, Schütz, Seifert, Selhuber-Unkel, Shenoy, Smith, Smith, Smith, Takagi, Thomas R. Weikl, Tolentino, Tordeux, Tsourkas, Tsourkas, Varma, Weikl, Weikl, Weikl, Weikl, Weikl, Williams, Winter, Wu, Yokosuka, Yokosuka, Yokosuka, Zhang, Zhu   +116 more
core   +2 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Phytosulfokine peptides, their receptors, and functions

Frontiers in Plant Science
Phytosulfokines (PSKs) are a class of disulfated pentapeptides and are regarded as plant peptide hormones. PSK-α, -γ, -δ, and -ϵ are four bioactive PSKs that are reported to have roles in plant growth, development, and immunity. In this review, we summarize recent advances in PSK biosynthesis, signaling, and function.
Yi Li, Qi Di, Li Luo, Liangliang Yu, Liangliang Yu   +4 more
openaire   +3 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Structural and Functional Insights into CRF Peptides and Their Receptors

Biology
Corticotropin-releasing factor or hormone (CRF or CRH) and the urocortins regulate a plethora of physiological functions and are involved in many pathophysiological processes.
Minos-Timotheos Matsoukas, Vasilis Panagiotopoulos, Vlasios Karageorgos, George P. Chrousos, Maria Venihaki, George Liapakis   +5 more
doaj   +1 more source