Results 161 to 170 of about 4,152 (219)
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Receptors for Relaxin Family Peptides
Annals of the New York Academy of Sciences, 2005Abstract: Recent studies have identified four receptors that are the physiological targets for relaxin family peptides. All are class I (rhodopsin like) G‐protein‐coupled receptors with LGR7 (RXFP1) and LGR8 (RXFP2) being type C leucine‐rich repeat‐containing receptors, whereas GPCR135 (RXFP3) and GPCR142 (RXFP4) resemble receptors that respond to ...
Bathgate, R. +4 more
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MHC molecules as peptide receptors
Current Opinion in Immunology, 1993The central unit for regulation of the specific immune system is a trimolecular complex made up of the T cell antigen receptor, the MHC molecule, and the MHC ligand. The third component is a peptide derived as a degradation product from a protein. During recent years there has been some progress in understanding the interaction between MHC molecules ...
H G, Rammensee, K, Falk, O, Rötzschke
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Peptide‐Based Carbohydrate Receptors
Chemistry – A European Journal, 2014AbstractA broad spectrum of physiological processes is mediated by highly specific noncovalent interactions of carbohydrates and proteins. In a recent communication we identified several cyclic hexapeptides in a dynamic combinatorial library that interact selectively with carbohydrates with high binding constants in water.
Melanie, Rauschenberg +3 more
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Non-peptide ligands for peptide receptors
Trends in Pharmacological Sciences, 1989Considerable progress has been made in synthesizing peptide analogs with improved stability for probing function of peptide-receptor systems. However, since peptide ligands are usually unsuitable for development as potent orally active long-duration therapeutic agents, considerable research effort is being directed to the development of non-peptidal ...
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Biology of natriuretic peptides and their receptors
Peptides, 2005Increasing evidence suggests that natriuretic peptides (NPs) play diverse roles in mammals, including renal hemodynamics, neuroendocrine, and cardiovascular functions. Collectively, NPs are classified as hypotensive hormones; the main actions of NPs are implicated in eliciting natriuretic, diuretic, steroidogenic, antiproliferative, and vasorelaxant ...
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Peptide YY receptors in the brain
Biochemical and Biophysical Research Communications, 1988Radiolabelled ligand binding studies demonstrated that specific receptors for peptide YY are present in the porcine as well as the canine brains. Peptide YY was bound to brain tissue membranes via high-affinity (dissociation constant, 1.39 X 10(-10)M) and low-affinity (dissociation constant, 3.72 X 10(-8)M) components.
A, Inui +9 more
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Receptor antagonists for gastrointestinal peptides
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1993Receptors for gastrointestinal peptides are all G protein-coupled receptors. Since the discovery that dibutyryl guanosine 3',5'-cyclic monophosphate was a cholecystokinin-receptor antagonist, a variety of receptor antagonists have been developed for a number of different gastrointestinal peptides.
M E, Presti, J D, Gardner
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Relaxin Family Peptides and Their Receptors
Physiological Reviews, 2013There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has many roles in female and male reproduction, as a neuropeptide in the central nervous system, as a vasodilator and cardiac stimulant in the cardiovascular system, and as an antifibrotic agent.
Bathgate, RAD +5 more
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Peptide Antagonist of the Androgen Receptor
Current Pharmaceutical Design, 2010Androgen receptor (AR) is a steroid hormone receptor that is activated by endogenous androgens, mainly testosterone and 5alpha-dihydrotestosterone (5alpha-DHT). AR is also an important drug target, and AR antagonists (antiandrogens) have been widely used for prostate cancer therapy.
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pH profile of a peptide receptor
Comparative Biochemistry and Physiology, 1969Abstract 1. 1. The activation of the feeding response in Hydra littoralis was used as a model system to investigate the mechanism by which a specific peptide activates its complementary cellular receptor to give a co-ordinated biological response. 2. 2. Through use of a modified Lineweaver-Burk equation and a modified Dixon equation, it was
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