Results 41 to 50 of about 255,087 (307)

Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]

, 1999
Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Brucker, Cosima, Downing, James E. G., Head, Gail M., Kendall, Marion D., Mentlein, Rolf   +4 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling [PDF]

, 2017
Signaling pathways can be linear, but more complex patterns are common. Growth factors and many other extracellular signals cannot directly enter cells and transduce their information via membrane-bound receptors.
Picard, D.
core  

Virtual screening for PPAR-gamma ligands using the ISOAK molecular graph kernel and gaussian processes [PDF]

, 2009
For a virtual screening study, we introduce a combination of machine learning techniques, employing a graph kernel, Gaussian process regression and clustered cross-validation.
Hansen, Katja, Müller, Klaus-Robert, Rupp, Matthias, Schneider, Gisbert (Prof. Dr.), Schroeter, Timon   +4 more
core   +1 more source

Steroid Hormone Receptors [PDF]

Archives of Disease in Childhood, 1984
Over the past twenty years there have been significant advances in the understanding of the biochemical mechanisms by which steroid hormone interaction with specific receptors elicits biological responses in target cells. A complete discussion of the available data on this subject is beyond the scope of this paper.
Paolo Marchetti, Gigliola Sica, Clara Natoli, Maria Assunta Spina, Stefano Iacobelli   +4 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Acute Responses of Different-sized Coronary Arteries to Testosterone [PDF]

, 2012
Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones such as testosterone are known to cause the relaxation of large coronary arteries.
Madanu, Sampath
core   +2 more sources

Genome-wide coexpression of steroid receptors in the mouse brain: Identifying signaling pathways and functionally coordinated regions [PDF]

, 2016
Steroid receptors are pleiotropic transcription factors that coordinate adaptation to different physiological states. An important target organ is the brain, but even though their effects are well studied in specific regions, brain-wide steroid receptor ...
Datson, N.A. (Nicole A.), Grefhorst, A. (Aldo), Lelieveldt, B.P.F. (Boudewijn), Mahfouz, A. (Ahmed), Meijer, O.C. (Onno C.), Mol, I.M. (Isabel), Reinders, M.J. (Marcel), Sips, H.C.M. (Hetty C.M.), Van Den Heuvel, J.K. (José K.), Van Weert, L.T.C.M. (Lisa T.C.M.), Visser, J.A. (Jenny A.)   +10 more
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Estradiol Receptor (ER) Chromatin Immunoprecipitation in MCF-7 Cells

Bio-Protocol, 2013
Steroid hormone receptors, for example estradiol receptor, act like transcription factors. In the cell, steroids bind to a specific receptor. Upon ligand binding, many steroid receptors dimerize and enter nuclei where they bind specific DNA sequences ...
Pia Giovannelli, Gabriella Castoria, Antimo Migliaccio   +2 more
doaj   +1 more source