Results 71 to 80 of about 110,518 (147)

Precision‐Guided Stealth Missiles in Biomedicine: Biological Carrier‐Mediated Nanomedicine Hitchhiking Strategy

open access: yesAdvanced Science, EarlyView.
Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou   +17 more
wiley   +1 more source

Frontiers in Nondrug Treatment of Sarcopenia: A Review of Pathological Mechanisms and the Latest Treatment Strategies

open access: yesAGING MEDICINE, EarlyView.
This article mainly introduces the pathologic process of sarcopenia and the recent progress in diagnosis and treatment, especially the nondrug treatment. ABSTRACT Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation,
Qi‐Fei Kuang   +2 more
wiley   +1 more source

Bowel preparation and surgical site infections in laparoscopic and robot‐assisted right‐sided colon cancer surgery with intracorporeal anastomosis: A retrospective study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This retrospective study investigated risk factors for surgical site infections (SSIs) in right‐sided colon cancer surgeries using intracorporeal anastomosis (IA). The results demonstrated that preoperative oral antibiotics (OA) significantly reduced SSI rates, with OA identified as an independent protective factor, suggesting its beneficial role in ...
Naoya Ozawa   +8 more
wiley   +1 more source

Optimal duration of antimicrobial prophylaxis in patients undergoing distal pancreatectomy: A multicenter cohort study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Prolonged administration of antimicrobial prophylaxis might not be effective to prevent surgical site infections after distal pancreatectomy compared to intraoperative or up to 24‐h administration. Abstract Background Antimicrobial prophylaxis is routinely administered in patients undergoing distal pancreatectomy, with cephalosporins being the most ...
Kenjiro Okada   +8 more
wiley   +1 more source

Prognostic impact of postoperative fixed‐point inflammation in patients with gastric cancer after curative gastrectomy: A validation cohort study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
The cutoff value of CRP by sex for poor OS remains unclear. This study aimed to determine the cutoff values of CRP on postoperative day 3 to predict poor OS in men and women with gastric cancer after radical gastrectomy. The high‐CRP group has poorer overall survival than the low‐CRP group for gastric cancer after gastrectomy.
Ryota Matsui   +7 more
wiley   +1 more source

Influence of Facility Size on Perioperative Outcomes in Minimally Invasive Esophagectomy for 14 152 Patients With Esophageal Cancer Based on the Japanese National Clinical Database: A Multicenter Cohort Study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This multicenter study investigated 14 152 minimally invasive esophagectomies (MIEs) using data from the Japanese National Clinical Database and showed a significantly lower operative mortality rate in high‐volume centers than in low‐volume centers. However, no differences in morbidity rates were found between facility sizes.
Taro Oshikiri   +4 more
wiley   +1 more source

Risk Evaluation of the NCD Risk Calculator for Open Pancreaticoduodenectomy in Elderly Patients: A Validation Study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This study investigated the utility of the Japanese NCD risk calculator for preoperative assessment in elderly patients undergoing pancreaticoduodenectomy (PD), using a validation study design. In the training cohort, two preoperative factors—the predicted incidence of postoperative ADL decline ≥ 44.8% and Clavien–Dindo grade IV or higher complications
Nana Kimura   +9 more
wiley   +1 more source

Prenatal Brain Abnormalities in Sodium‐Dependent Multivitamin Transporter Deficiency

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT In treatable neurometabolic disorders, early diagnosis and prompt initiation of treatment are key to improved survival and outcomes. Biallelic variants in SLC5A6 cause sodium‐dependent multivitamin transporter deficiency (OMIM # 618973), which is treatable with high‐dose pantothenic acid, biotin, and alpha lipoic acid.
Eri Ogawa   +2 more
wiley   +1 more source

Superior Benefits of Combining Mepolizumab With Sinus Surgery Compared to Mepolizumab Alone: Results From a Randomised 6‐Month Trial

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) significantly impacts patients’ quality of life (QoL). Standard treatments include nasal irrigations, nasal steroids, systemic corticosteroids, and functional endoscopic sinus surgery (FESS).
Anne‐Sophie Homøe   +7 more
wiley   +1 more source

Differential Immune Cell Infiltration in Eosinophilic and Non‐Eosinophilic CRS: Correlations With Clinical, Endoscopic, and Radiological Findings

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The pathogenesis of inflammation in eosinophilic chronic rhinosinusitis (ECRS) and non‐eosinophilic chronic rhinosinusitis (NECRS) remains poorly understood. This study aimed to assess immune cell infiltration within the sinonasal microenvironment in these conditions.
Katarzyna Czerwaty   +5 more
wiley   +1 more source

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