Results 91 to 100 of about 798,182 (300)

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

EVALUATION OF STEROID HORMONES AND THEIR RECEPTORS IN DEVELOPMENT AND PROGRESSION OF RENAL CELL CARCINOMA

Journal of Kidney Cancer and VHL, 2014
Steroid hormones and their receptors have important roles in normal kidney biology, and alterations in their expression and function help explain the differences in development of kidney diseases, such as nephrotic syndrome and chronic kidney disease ...
Nigel Bennett, Retnagowri Rajandram, Keng Lim Ng, Glenda C Gobe   +3 more
doaj   +1 more source

Minireview: Tipping the balance: ligand-independent activation of steroid receptors

, 2015
Steroid receptors are prototypical ligand-dependent transcription factors and a textbook example for allosteric regulation. According to this canonical model, binding of cognate steroid is an absolute requirement for transcriptional activation ...
Picard, Didier, Bennesch, Marcela
core   +1 more source

Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat [PDF]

, 2001
The experiments explored the nature and time course of changes in glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) binding in homogenates of various brain regions and pituitary of male Wistar rats following social defeat stress.
Horváth, K.M., Bohus, B., Bohus, B, Bauke Buwalda, Nyakas, C, Felszeghy, K., Felszeghy, K, Béla Bohus, Klára Felszeghy, Horváth, Katalin M.,, Koolhaas, J M, Buwalda, B, Boer, Sietse F. de,, Nyakas, Csaba,, Csaba Nyakas, Katalin M Horváth, de Boer, S.F., Felszeghy, Klára,, Koolhaas, J.M., Sietse F de Boer, Koolhaas, Jaap M.,, Nyakas, C., Buwalda, Bauke,, Horváth, K M, Buwalda, B., Bohus, Béla,, Jaap M Koolhaas   +26 more
core   +1 more source

Regulation by Gonadal Steroids of Estrogen and Progesterone Receptors Along the Reproductive Tract in Female Lambs

Acta Veterinaria Scandinavica, 2001
The regulation of estrogen and progesterone receptor (ER, PR) expression by estradiol (E2) and progesterone (P4) in the oviduct, uterus and cervix of female lambs was studied. The animals received three intramuscular injections of E2, P4 or vehicle with
Rodríguez-Piñón M, Garófalo EG, Meikle A, Tasende C, Sahlin L   +4 more
doaj   +1 more source

Steroid hormones: Interactions with membrane-bound receptors [PDF]

, 1999
Steroid hormones are generally thought to pass easily across a plasma membrane into a cell, interacting once inside with soluble nuclear receptors, but recent experiments have demonstrated the importance of membrane-bound receptors in mediating the ...
Farese, Robert V., Robert V. Farese, Hubert C. Chen, Chen, Hubert C.   +3 more
core   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

Steroid signaling activation and intracellular localization of sex steroid receptors

, 2010
In addition to stimulating gene transcription, sex steroids trigger rapid, non-genomic responses in the extranuclear compartment of target cells.
Pia Giovannelli, Di Donato M, Auricchio F., Antimo Migliaccio, Ferdinando Auricchio, Giraldi T, CASTORIA, Gabriella, MIGLIACCIO, Antimo, Tiziana Giraldi, Gabriella Castoria, Marzia Di Donato, Giovannelli P   +11 more
core   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

Short‐Term Response to Biologic Therapy in Psoriatic Arthritis Is Not Influenced by Disease Duration at Initiation of Therapy

Arthritis Care &Research, EarlyView.
Objective We aimed to determine whether the short‐term response to biologics in biologic‐naive psoriatic arthritis (PsA) is better in patients initiating biologic treatment early in the disease course. Methods Patients with PsA who started on biologic therapy from the year 2000 to 2025 were included for analysis.
Sung Min Cho, Shangyi Gao, Daniel Pereira, Richard J. Cook, Dafna D. Gladman   +4 more
wiley   +1 more source