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Inhibiting glucocorticoid receptors enhances adult spinal cord neural stem cell activity and improves outcomes in spinal cord injury [PDF]
Communications BiologyThe spinal cord injury (SCI) microenvironment undergoes significant biochemical changes that influence the behavior of endogenous neural stem/progenitor cells (NSPCs), including elevated glucocorticoid levels.
Xuefeng Zhang +5 more
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PLoS ONE, 2022 Obesity, which has become a major global health problem, involves a constitutive increase in adipocyte differentiation signaling. Previous studies show that mesenchymal stem cells (MSCs) induce weight loss and glycemic control. However, the mechanisms by
Yu-Hee Kim +4 more
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B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
Neurobiology of Stress, 2023 Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett +2 more
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Frontiers in Psychiatry, 2022 IntroductionAbnormal cortisol suppression in borderline personality disorder has been consistently reported in previous studies, suggesting that a hypersensitivity response of the hypothalamic-pituitary-adrenal (HPA) axis might occur in these patients ...
José Manuel López-Villatoro +16 more
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Glucocorticoid Receptor Signaling in Diabetes [PDF]
International Journal of Molecular Sciences, 2021 Stress and depression increase the risk of Type 2 Diabetes (T2D) development. Evidence demonstrates that the Glucocorticoid (GC) negative feedback is impaired (GC resistance) in T2D patients resulting in Hypothalamic-Pituitary-Adrenal (HPA) axis hyperactivity and hypercortisolism.
Ioanna Kokkinopoulou +2 more
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Mitochondrial Glucocorticoid Receptors and Their Actions [PDF]
International Journal of Molecular Sciences, 2021 Mitochondria are membrane organelles present in almost all eukaryotic cells. In addition to their well-known role in energy production, mitochondria regulate central cellular processes, including calcium homeostasis, Reactive Oxygen Species (ROS) generation, cell death, thermogenesis, and biosynthesis of lipids, nucleic acids, and steroid hormones ...
Kokkinopoulou, I., Moutsatsou, P.
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PLoS ONE, 2020 Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticosterone
John R Pooley +9 more
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Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
Nature Communications, 2021 Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to
Karen R. Mifsud +13 more
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Frontiers in Endocrinology, 2022 Kisspeptin plays a vital role in mediating the stress-induced reproductive regulation. Cortisol, known as a stress-related hormone, is involved in gonadal development and sexual differentiation by binding with glucocorticoid receptor (GR) to regulate the
Shao-Yang Bu +6 more
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Hippocampal glucocorticoid receptors modulate status epilepticus severity
Neurobiology of Disease, 2023 Status epilepticus (SE) is a life-threatening medical emergency with significant morbidity and mortality. SE is associated with a robust and sustained increase in serum glucocorticoids, reaching concentrations sufficient to activate the dense population ...
Kimberly L. Kraus +7 more
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