Results 1 to 10 of about 149,031 (311)

Conditioned medium from human tonsil-derived mesenchymal stem cells inhibits glucocorticoid-induced adipocyte differentiation.

PLoS ONE, 2022
Obesity, which has become a major global health problem, involves a constitutive increase in adipocyte differentiation signaling. Previous studies show that mesenchymal stem cells (MSCs) induce weight loss and glycemic control. However, the mechanisms by
Yu-Hee Kim, Hyun-Ji Lee, Kyung-Ah Cho, So-Youn Woo, Kyung-Ha Ryu   +4 more
doaj   +2 more sources

B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity

Neurobiology of Stress, 2023
Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett, Guia Guffanti, Richard G. Hunter   +2 more
doaj   +1 more source

Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder

Frontiers in Psychiatry, 2022
IntroductionAbnormal cortisol suppression in borderline personality disorder has been consistently reported in previous studies, suggesting that a hypersensitivity response of the hypothalamic-pituitary-adrenal (HPA) axis might occur in these patients ...
José Manuel López-Villatoro, Karina S. MacDowell, Karina S. MacDowell, Karina S. MacDowell, Karina S. MacDowell, Marina Diaz-Marsá, Marina Diaz-Marsá, Alejandro De La Torre-Luque, Alejandro De La Torre-Luque, Clara Prittwitz, Alejandra Galvez-Merlin, Juan C. Leza, Juan C. Leza, Juan C. Leza, Juan C. Leza, Jose L. Carrasco, Jose L. Carrasco   +16 more
doaj   +1 more source

Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA.

PLoS ONE, 2020
Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticosterone
John R Pooley, Caroline A Rivers, Michael T Kilcooley, Susana N Paul, Ayse Derya Cavga, Yvonne M Kershaw, Serena Muratcioglu, Attila Gursoy, Ozlem Keskin, Stafford L Lightman   +9 more
doaj   +1 more source

Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors

Nature Communications, 2021
Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to
Karen R. Mifsud, Clare L. M. Kennedy, Silvia Salatino, Eshita Sharma, Emily M. Price, Samantha N. Haque, Andriana Gialeli, Hannah M. Goss, Polina E. Panchenko, John Broxholme, Simon Engledow, Helen Lockstone, Oscar Cordero Llana, Johannes M. H. M. Reul   +13 more
doaj   +1 more source

Regulation of the kiss2 promoter in yellowtail clownfish (Amphiprion clarkii) by cortisol via GRE-dependent GR pathway

Frontiers in Endocrinology, 2022
Kisspeptin plays a vital role in mediating the stress-induced reproductive regulation. Cortisol, known as a stress-related hormone, is involved in gonadal development and sexual differentiation by binding with glucocorticoid receptor (GR) to regulate the
Shao-Yang Bu, Yan-Yu Zhang, Xian Zhang, Tian-Xiu Li, De-Cai Zheng, Ze-Xiang Huang, Qian Wang   +6 more
doaj   +1 more source

Hippocampal glucocorticoid receptors modulate status epilepticus severity

Neurobiology of Disease, 2023
Status epilepticus (SE) is a life-threatening medical emergency with significant morbidity and mortality. SE is associated with a robust and sustained increase in serum glucocorticoids, reaching concentrations sufficient to activate the dense population ...
Kimberly L. Kraus, Nawshaba Nawreen, Christin M. Godale, Arihant P. Chordia, Ben Packard, Candi L. LaSarge, James P. Herman, Steve C. Danzer   +7 more
doaj   +1 more source

Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine. [PDF]

PLoS ONE, 2018
Previous research has shown that fibroblast growth factor 2 protein (FGF2) can act as an anxiolytic and anti-depressive agent in rodents. Levels of hippocampal FGF2 and FGF2 receptors are decreased in post-mortem brains of individuals with mood disorders.
Stephanie Simard, Pragya Shail, Jessica MacGregor, Maha El Sayed, Ronald S Duman, Flora M Vaccarino, Natalina Salmaso   +6 more
doaj   +1 more source

Genomic regulation of Krüppel-like-factor family members by corticosteroid receptors in the rat brain

Neurobiology of Stress, 2023
Hippocampal mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) mediate glucocorticoid hormone (GC) action in the hippocampus.
Clare L.M. Kennedy, Emily M. Price, Karen R. Mifsud, Silvia Salatino, Eshita Sharma, Simon Engledow, John Broxholme, Hannah M. Goss, Johannes M.H.M. Reul   +8 more
doaj   +1 more source

Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms

Cells, 2020
A major risk factor for major depressive disorder (MDD) is stress. Stress leads to the release of high-mobility group box-1 (HMGB1), which in turn leads to neuroinflammation, a potential pathophysiological basis of MDD.
Kazue Hisaoka-Nakashima, Honami Azuma, Fumina Ishikawa, Yoki Nakamura, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Yoshihiro Nakata, Norimitsu Morioka   +9 more
doaj   +1 more source