Hippocampal glucocorticoid receptors modulate status epilepticus severity [PDF]
Neurobiology of Disease, 2023 Status epilepticus (SE) is a life-threatening medical emergency with significant morbidity and mortality. SE is associated with a robust and sustained increase in serum glucocorticoids, reaching concentrations sufficient to activate the dense population ...
Kimberly L. Kraus +7 more
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Role of Glucocorticoids and Glucocorticoid Receptors in Glaucoma Pathogenesis. [PDF]
Cells, 2023 The glucocorticoid receptor (GR), including both alternative spliced isoforms (GRα and GRβ), has been implicated in the development of primary open-angle glaucoma (POAG) and iatrogenic glucocorticoid-induced glaucoma (GIG). POAG is the most common form of glaucoma, which is the leading cause of irreversible vision loss and blindness in the world ...
Patel PD, Kodati B, Clark AF.
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Inhibiting glucocorticoid receptors enhances adult spinal cord neural stem cell activity and improves outcomes in spinal cord injury [PDF]
Communications BiologyThe spinal cord injury (SCI) microenvironment undergoes significant biochemical changes that influence the behavior of endogenous neural stem/progenitor cells (NSPCs), including elevated glucocorticoid levels.
Xuefeng Zhang +5 more
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Mitochondrial Glucocorticoid Receptors and Their Actions. [PDF]
Int J Mol Sci, 2021 Mitochondria are membrane organelles present in almost all eukaryotic cells. In addition to their well-known role in energy production, mitochondria regulate central cellular processes, including calcium homeostasis, Reactive Oxygen Species (ROS) generation, cell death, thermogenesis, and biosynthesis of lipids, nucleic acids, and steroid hormones ...
Kokkinopoulou I, Moutsatsou P.
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Cocaine disrupts action flexibility via glucocorticoid receptors [PDF]
iScienceSummary: Many addictive drugs increase stress hormone levels. They also alter the propensity of organisms to prospectively select actions based on long-term consequences.
Michelle K. Sequeira +4 more
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Placental glucocorticoid receptors are not affected by maternal depression or SSRI treatment [PDF]
Upsala Journal of Medical Sciences, 2020 Background: Prenatal depression is common, with an estimate that up to one in five pregnant women suffers from depressive symptoms. Maternal depression is associated with poor pregnancy outcomes such as preterm birth and low birth-weight.
Åsa Edvinsson +6 more
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False Opposing Fear Memories Are Produced as a Function of the Hippocampal Sector Where Glucocorticoid Receptors Are Activated [PDF]
Frontiers in Behavioral Neuroscience, 2020 Injection of corticosterone (CORT) in the dorsal hippocampus (DH) can mimic post-traumatic stress disorder (PTSD)—related memory in mice: both maladaptive hypermnesia for a salient but irrelevant simple cue and amnesia for the traumatic context. However,
Nadia Kaouane +8 more
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Adrenergic and Glucocorticoid Receptors in the Pulmonary Health Effects of Air Pollution [PDF]
Toxics, 2021 Andres R Henriquez +2 more
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PLoS ONE, 2022 Obesity, which has become a major global health problem, involves a constitutive increase in adipocyte differentiation signaling. Previous studies show that mesenchymal stem cells (MSCs) induce weight loss and glycemic control. However, the mechanisms by
Yu-Hee Kim +4 more
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B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
Neurobiology of Stress, 2023 Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett +2 more
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