Results 31 to 40 of about 149,031 (311)

Dexamethasone and RU24858 induce survival and growth factor receptor bound protein 2, leukotriene B4 receptor 1 and annexin-1 expression in primary human neutrophils [PDF]

, 2012
Glucocorticoids are widely used anti-inflammatory medication in diseases like asthma and chronic obstructive pulmonary disease. Glucocorticoids can either activate (transactivation) or inhibit (transrepression) transcription. RU24858 was introduced as a
Adcock, I, Hasala, H, Janka-Junttila, M, Kankaanranta, H, Moilanen, E   +4 more
core   +3 more sources

Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.

PLoS ONE, 2014
The steroid hormone receptors regulate important physiological functions such as reproduction, metabolism, immunity, and electrolyte balance. Mutations within steroid receptors result in endocrine disorders and can often drive cancer formation and ...
William H Hudson, Christine Youn, Eric A Ortlund   +2 more
doaj   +1 more source

Neurobiological Mechanisms That Contribute to Stress-related Cocaine Use [PDF]

, 2014
The ability of stressful life events to trigger drug use is particularly problematic for the management of cocaine addiction due to the unpredictable and often uncontrollable nature of stress.
Ahmed, Ahmed, Ambroggi, Amphoux, Asanuma, Back, Badrinarayan, Barik, Beckerman, Beckstead, Behan, Berridge, Blacktop, Brady, Briand, Brischoux, Broadbear, Brown, Brown, Bruijnzeel, Buffalari, Butts, Campioni, Capriles, Chen, Cintra, Coffey, Conrad, Cottler, Day, de Jong, de Kloet, De La Garza, De Vries, Deroche-Gamonet, Dobi, Dong, Duan, Dumont, Duncan, Egli, Engel, Erb, Erb, Erb, Erb, Erb, Erb, Feltenstein, Forray, Fox, Fox, Galici, Gasser, Gasser, Geisler, Georges, Ghitza, Goeders, Gonzalez-Islas, Gorboulev, Graf, Graf, Gründemann, Hahn, Harfstrand, Iversen, Jayme R. McReynolds, Jennings, Jobes, John R. Mantsch, Jordan M. Blacktop, Kalivas, Kash, Kippin, Koob, Koob, Korotkova, Kreibich, Kudo, Lee, Leri, Lewis, Lodge, Lê, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, McEwen, McFarland, Nobis, Oleson, Oliver Vranjkovic, Orio, Ostrander, Paul J. Gasser, Preston, Rainbow, Redila, Refojo, Ribeiro Do Couto, Riegel, Robert C. Twining, Rodaros, Roitman, Rounsaville, Saal, Sanchez, Sartor, Schulkin, Seamans, Shaham, Shaham, Shaham, Shalev, Shelton, Shields, Shin, Silberman, Sinha, Sinha, Sinha, Smith, Specio, Steffensen, Tagliaferro, Tasker, Ungless, Ungless, Ungless, Van Pett, Vialou, Vranjkovic, Wanat, Wang, Wang, Wang, Wang, Ward, Wee, Wee, Wei, Wellman, Wise, Yamaguchi, Zahm, Zoli   +149 more
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Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor α In Endometrial Cancer

Cell Reports, 2018
Summary: Steroid hormone receptors are simultaneously active in many tissues and are capable of altering each other’s function. Estrogen receptor α (ER) and glucocorticoid receptor (GR) are expressed in the uterus, and their ligands have opposing effects
Jeffery M. Vahrenkamp, Chieh-Hsiang Yang, Adriana C. Rodriguez, Aliyah Almomen, Kristofer C. Berrett, Alexis N. Trujillo, Katrin P. Guillen, Bryan E. Welm, Elke A. Jarboe, Margit M. Janat-Amsbury, Jason Gertz   +10 more
doaj   +1 more source

Steroids, Pregnancy and Fetal Development

Frontiers in Immunology, 2020
Maternal glucocorticoids critically rise during pregnancy reaching up to a 20-fold increase of mid-pregnancy concentrations. Concurrently, another steroid hormone, progesterone, increases.
Maria Emilia Solano, Petra Clara Arck
doaj   +1 more source

Sexual dimorphic role of the glucocorticoid receptor in chronic muscle pain produced by early-life stress

Molecular Pain, 2021
Fibromyalgia and other chronic musculoskeletal pain syndromes are associated with stressful early life events, which can produce a persistent dysregulation in the hypothalamic-pituitary adrenal (HPA) stress axis function, associated with elevated plasm ...
Paul G Green, Pedro Alvarez, Jon D Levine   +2 more
doaj   +1 more source

Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression [PDF]

Journal of Integrative Neuroscience, 2020
Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity. Honokiol, a biphenolic lignan compound obtained from the traditional Chinese medicine Magnolia officinalis, can reduce the activity of the hypothalamus-pituitary-adrenal ...
Bo Zhang, Yu Li, Miao Liu, Xiao-Hua Duan, Kai-Li Hu, Li-Na Li, Xue Yu, Hong-Sheng Chang
doaj   +1 more source

Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1:physiological regulator and pharmacological target for energy partitioning [PDF]

, 2007
The major glucocorticoid in man, cortisol, plays important roles in regulating fuel metabolism, energy partitioning and body fat distribution.
Alberts, Andrew, Brian R. Walker, Garrel, Havel, Lottenberg, Nowak, Pasquali, Paulmyer-Lacroix, Phillipou, Rask, Rosmond, Sapolsky, Stewart, Walker   +14 more
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Temporal and spatial dynamics of corticosteroid receptor down-regulation in rat brain following social defeat [PDF]

, 2001
The experiments explored the nature and time course of changes in glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) binding in homogenates of various brain regions and pituitary of male Wistar rats following social defeat stress.
Boer, Sietse F. de,, Bohus, Béla,, Buwalda, Bauke,, Felszeghy, Klára,, Horváth, Katalin M.,, Koolhaas, Jaap M.,, Nyakas, Csaba,   +6 more
core   +1 more source

Stress-induced enhancement of mouse amygdalar synaptic plasticity depends on glucocorticoid and ß-adrenergic activity. [PDF]

PLoS ONE, 2012
BACKGROUND: Glucocorticoid hormones, in interaction with noradrenaline, enable the consolidation of emotionally arousing and stressful experiences in rodents and humans.
Ratna Angela Sarabdjitsingh, Daniel Kofink, Henk Karst, E Ron de Kloet, Marian Joëls   +4 more
doaj   +1 more source