Results 51 to 60 of about 90,980 (312)

Stress-induced enhancement of mouse amygdalar synaptic plasticity depends on glucocorticoid and ß-adrenergic activity. [PDF]

PLoS ONE, 2012
BACKGROUND: Glucocorticoid hormones, in interaction with noradrenaline, enable the consolidation of emotionally arousing and stressful experiences in rodents and humans.
Ratna Angela Sarabdjitsingh, Daniel Kofink, Henk Karst, E Ron de Kloet, Marian Joëls   +4 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism. [PDF]

PLoS ONE, 2012
GLUCOCORTICOIDS are steroid hormones that strongly influence intermediary carbohydrate metabolism by increasing the transcription rate of glucose-6-phosphatase (G6Pase), a key enzyme of gluconeogenesis, and suppress the immune system through the ...
Nancy Nader, Sinnie Sin Man Ng, Yonghong Wang, Brent S Abel, George P Chrousos, Tomoshige Kino   +5 more
doaj   +1 more source

Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells [PDF]

, 2012
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes involved in drug metabolism and defence against oxidative stress.
Denise V. Kratschmar (165140), Diego Calabrese, Diego Calabrese (165146), Moulin, Pierre, Birk, Julia, Pierre Moulin, Appenzeller-Herzog, Christian, Calabrese, Diego, Christian Appenzeller-Herzog (165171), Lister Adam, Lister, Adam, Alex Odermatt (27423), Pierre Moulin (106353), Adam Lister (165158), Walsh Jo, Appenzeller-Herzog Christian, Moulin Pierre, Goldring Chris E., Chris E. Goldring (165179), Birk Julia, Jo Walsh, Jo Walsh (165152), Chris E Goldring, Kratschmar, Denise V., Denise V Kratschmar, Calabrese Diego, Goldring, Chris E., Kratschmar Denise V., Walsh, Jo, Julia Birk, Julia Birk (165165), Alex Odermatt, Odermatt Alex, Adam Lister, Odermatt, Alex, Christian Appenzeller-Herzog   +35 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Melanocortin Regulation of Inflammation

Frontiers in Endocrinology, 2019
Adrenocorticotropic hormone (ACTH), and α-, β-, and γ-melanocyte-stimulating hormones (α-, β-, γ-MSH), collectively known as melanocortins, together with their receptors (melanocortin receptors), are components of an ancient modulatory system.
Wei Wang, Dong-Yu Guo, Yue-Jun Lin, Ya-Xiong Tao   +3 more
doaj   +1 more source

Allosteric Modulators of Steroid Hormone Receptors : Structural Dynamics and Gene Regulation [PDF]

, 2012
Peer ...
McEwan, Iain J, Kumar, Raj
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

The Mechanism of Steroid Hormones in Non-Small Cell Lung Cancer: From Molecular Signaling to Clinical Application

Biomedicines
Steroid hormones play critical roles in the development and progression of NSCLC through both genomic and non-genomic pathways. This review summarizes the expression profiles and molecular functions of estrogen, progesterone, androgen, and glucocorticoid
Yao Wang, Ying Zhou, Yao Yao, Caihong Zheng   +3 more
doaj   +1 more source