Results 51 to 60 of about 669,888 (299)

The Mechanism of Steroid Hormones in Non-Small Cell Lung Cancer: From Molecular Signaling to Clinical Application

Biomedicines
Steroid hormones play critical roles in the development and progression of NSCLC through both genomic and non-genomic pathways. This review summarizes the expression profiles and molecular functions of estrogen, progesterone, androgen, and glucocorticoid
Yao Wang, Ying Zhou, Yao Yao, Caihong Zheng   +3 more
doaj   +1 more source

Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons

Frontiers in Pharmacology, 2018
The exposure to supra-physiological levels of glucocorticoids in prenatal life can lead to a long-term impact in brain cytoarchitecture, increasing the susceptibility to neuropsychiatric disorders.
Helena Pinheiro, Helena Pinheiro, Rita Gaspar, Rita Gaspar, Filipa I. Baptista, Filipa I. Baptista, Carlos A. Fontes-Ribeiro, Carlos A. Fontes-Ribeiro, Carlos A. Fontes-Ribeiro, António F. Ambrósio, António F. Ambrósio, António F. Ambrósio, Catarina A. Gomes, Catarina A. Gomes, Catarina A. Gomes   +14 more
doaj   +1 more source

3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and deoxycorticosterone [PDF]

, 2011
The serum of Atlantic sea lamprey, a basal vertebrate, contains two corticosteroids, 11-deoxycortisol and deoxycorticosterone. Only 11-deoxycortisol has high affinity [Kd~3 nM] for the corticoid receptor [CR] in lamprey gill cytosol. To investigate the
Paiyuam Asnaashari, Michael E. Baker, Kayla Y. Uh   +2 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The role of endogenous annexin A1 on leukocyte biology [PDF]

, 2005
PhDInflammation is the body's innate immune response to the damage caused to its cells and vascularised tissue, either by injury or microbial pathogens.
Yona, Simon
core   +4 more sources

Effect of neonatal dexamethasone treatment on cognitive abilities of adult male mice and gene expression in the hypothalamus

Вавиловский журнал генетики и селекции, 2019
The early postnatal period is critical for the development of the nervous system. Stress during this period causes negative long-term effects, which are manifested at both behavioral and molecular levels.
N. P. Bondar, V. V. Reshetnikov, K. V. Burdeeva, T. I. Merkulova   +3 more
doaj   +1 more source

Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala

, 2005
Glucocorticoids, released in high concentrations from the adrenal cortex during stressful experiences, bind to glucocorticoid receptors in nuclear and peri-nuclear sites in neuronal somata.
McEwen, B. S., LeDoux, J. E., Morrison, J. H., Johnson, Luke R., Farb, C.   +4 more
core   +1 more source

Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells [PDF]

, 2012
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes involved in drug metabolism and defence against oxidative stress.
Denise V. Kratschmar (165140), Diego Calabrese, Diego Calabrese (165146), Moulin, Pierre, Birk, Julia, Pierre Moulin, Appenzeller-Herzog, Christian, Calabrese, Diego, Christian Appenzeller-Herzog (165171), Lister Adam, Lister, Adam, Alex Odermatt (27423), Pierre Moulin (106353), Adam Lister (165158), Walsh Jo, Appenzeller-Herzog Christian, Moulin Pierre, Goldring Chris E., Chris E. Goldring (165179), Birk Julia, Jo Walsh, Jo Walsh (165152), Chris E Goldring, Kratschmar, Denise V., Denise V Kratschmar, Calabrese Diego, Goldring, Chris E., Kratschmar Denise V., Walsh, Jo, Julia Birk, Julia Birk (165165), Alex Odermatt, Odermatt Alex, Adam Lister, Odermatt, Alex, Christian Appenzeller-Herzog   +35 more
core   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Activation of Glucocorticoid Receptors By Thioredoxin.

, 1984
Rat liver cytosol contains two distinct heat-stable activities that affect the binding capacity of glucocorticoid receptors. One activity activates receptors from a non-binding to a steroid-binding form and the other stabilizes the activated receptors ...
Grippo, Joseph F.
core   +5 more sources