Results 51 to 60 of about 149,031 (311)

The Mechanism of Steroid Hormones in Non-Small Cell Lung Cancer: From Molecular Signaling to Clinical Application

Biomedicines
Steroid hormones play critical roles in the development and progression of NSCLC through both genomic and non-genomic pathways. This review summarizes the expression profiles and molecular functions of estrogen, progesterone, androgen, and glucocorticoid
Yao Wang, Ying Zhou, Yao Yao, Caihong Zheng   +3 more
doaj   +1 more source

Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons

Frontiers in Pharmacology, 2018
The exposure to supra-physiological levels of glucocorticoids in prenatal life can lead to a long-term impact in brain cytoarchitecture, increasing the susceptibility to neuropsychiatric disorders.
Helena Pinheiro, Helena Pinheiro, Rita Gaspar, Rita Gaspar, Filipa I. Baptista, Filipa I. Baptista, Carlos A. Fontes-Ribeiro, Carlos A. Fontes-Ribeiro, Carlos A. Fontes-Ribeiro, António F. Ambrósio, António F. Ambrósio, António F. Ambrósio, Catarina A. Gomes, Catarina A. Gomes, Catarina A. Gomes   +14 more
doaj   +1 more source

Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]

, 2019
FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran, Dou, Longyu, Liang, Tiebing, Liu, Ming, Qiu, Bin, Ren, Wei, Shou, Weinian, Stewart, Robert B., Wang, Chao, Wang, Jun, Williams, Kent E., Xie, Zhongwen, Xu, Yuxue, Yong, Weidong, Zhao, Zhenwen   +14 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Effect of neonatal dexamethasone treatment on cognitive abilities of adult male mice and gene expression in the hypothalamus

Вавиловский журнал генетики и селекции, 2019
The early postnatal period is critical for the development of the nervous system. Stress during this period causes negative long-term effects, which are manifested at both behavioral and molecular levels.
N. P. Bondar, V. V. Reshetnikov, K. V. Burdeeva, T. I. Merkulova   +3 more
doaj   +1 more source

Influence of pre-reproductive maternal enrichment on coping response to stress and expression of c-Fos and glucocorticoid receptors in adolescent offspring [PDF]

, 2017
Environmental enrichment (EE) is an experimental setting broadly used for investigating the effects of complex social, cognitive, and sensorimotor stimulations on brain structure and function.
Begega, Azucena, Berretta, Erica, Caporali, Paola, Cutuli, Debora, DE BARTOLO, Paola, Foti, FRANCESCA IRENE, Gelfo, Francesca, Laricchiuta, Daniela, Pasqualini, Greta, Pesoli, Matteo, Petrosini, Laura, Sampedro Piquero, Patricia   +11 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Placental glucocorticoid receptors are not affected by maternal depression or SSRI treatment

Upsala Journal of Medical Sciences, 2020
Background: Prenatal depression is common, with an estimate that up to one in five pregnant women suffers from depressive symptoms. Maternal depression is associated with poor pregnancy outcomes such as preterm birth and low birth-weight.
Åsa Edvinsson, Angela Hoyer, Malin Hansson, Theodora Kunovac Kallak, Inger Sundström-Poromaa, Alkistis Skalkidou, Susanne Lager   +6 more
doaj   +1 more source

The Pathophysiology and Treatment of Hypertension in Patients With Cushing's Syndrome [PDF]

, 2019
When hypertension, a pathology that is frequently found in the general population, presents in a young patient, secondary causes such as Cushing's syndrome (CS), a rare disease characterized by long-term elevated cortisol levels, should be considered ...
Barbot, Mattia, Ceccato, Filippo, Scaroni, Carla   +2 more
core   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source