Results 71 to 80 of about 91,243 (312)

Glucocorticoid receptors in lymphocytes and stability of kidney graft function [PDF]

, 2001
The glucocorticoid receptors in lymphocytes of patients treated with glucocorticoids after kidney transplantation have been studied in order to determine whether abnormalities in corticosteroid binding and trans-activation of steroid-receptor complexes ...
Vulović, Mojca D., Vulović, Mojica, Blagojevic, R, Ribarac-Stepić, Nevena B., Djukanovic, L, Isenović, Esma R., Žakula, Zorica, Naumovic, R, Korićanac, Goran   +8 more
core   +1 more source

Cocaine disrupts action flexibility via glucocorticoid receptors

iScience
Summary: Many addictive drugs increase stress hormone levels. They also alter the propensity of organisms to prospectively select actions based on long-term consequences.
Michelle K. Sequeira, Kathryn M. Stachowicz, Esther H. Seo, Sophie T. Yount, Shannon L. Gourley   +4 more
doaj   +1 more source

Early life stress-induced alterations in rat brain structures measured with high resolution MRI. [PDF]

PLoS ONE, 2017
Adverse experiences early in life impair cognitive function both in rodents and humans. In humans this increases the vulnerability to develop mental illnesses while in the rodent brain early life stress (ELS) abnormalities are associated with changes in ...
R Angela Sarabdjitsingh, Manila Loi, Marian Joëls, Rick M Dijkhuizen, Annette van der Toorn   +4 more
doaj   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

Arthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah, Sangmee S. Bae, Tiffany De Leon, Yuna Lee, Rong Guo, David Elashoff, Jennifer Wang, Ani Shahbazian, Christina Charles‐Schoeman   +8 more
wiley   +1 more source

Cardiac response to chronic restraint stress involves mineralocorticoid receptors in male Sprague–Dawley rats

Physiological Reports
In the present study, we aimed at elucidating whether exposure to chronic stress affects the expression of cardiac mineralocorticoid receptors (MRs), whether it influences cardiac structure and function, and whether MRs blockade attenuates the stress ...
D. Sztechman, T. Zera, K. Czarzasta, E. Szczepanska‐Sadowska, A. Cudnoch‐Jedrzejewska   +4 more
doaj   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Mineralocorticoid and glucocorticoid receptors in human kidney [PDF]

, 1976
Mineralocorticoid and glucocorticoid receptors in human kidney.Currently, studies on renal mineralocorticoid and glucocorticoid receptors have been confined to experimental animals.
Fuller, Peter J., Funder, John W.
core   +1 more source

Endocrine-Disrupting Activities of Flavones on Steroid Receptors: Structural Requirements and Synthesis of Novel Flavone with Improved Estrogenic Activity

Biomedicines
Background/Objectives: Flavonoids are common ubiquitous components of plants and are consumed by humans and livestock in their diets. Many different activities have been proposed for a variety of flavonoids that play a role in the benefits of a plant ...
Steven K. Nordeen, Vijay Kumar, Betty J. Bona, Joshua D. Batson, Donald S. Backos, Michael F. Wempe   +5 more
doaj   +1 more source

Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR

Cell Death and Disease, 2023
The physiological crosstalk between glucocorticoid and melatonin maintains neuronal homeostasis in regulating circadian rhythms. However, the stress-inducing level of glucocorticoid triggers mitochondrial dysfunction including defective mitophagy by ...
Min Jeong Kim, Gee Euhn Choi, Chang Woo Chae, Jae Ryong Lim, Young Hyun Jung, Jee Hyeon Yoon, Ji Yong Park, Ho Jae Han   +7 more
doaj   +1 more source