Results 191 to 200 of about 1,185,623 (252)

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Risk Factors Influencing Efficacy and Prognosis Evaluation of Neoadjuvant Systemic Therapy in Triple‐Positive Breast Cancer

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao   +7 more
wiley   +1 more source

DARS2 Promotes Tumorigenesis and Metastasis by Activating PI3K/Akt/GSK‐3β/β‐Catenin Signaling Pathway in Breast Cancer

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Aspartyl‐tRNA synthetase 2 (DARS2), the mitochondrial enzyme responsible for aminoacylation of aspartyl‐tRNA, is traditionally known for its effect on protein synthesis. Recently, DARS2 is reported to be implicated in tumorigenesis. However, its specific effect on breast cancer (BC) is poorly understood.
Na Wang, Ming Huang
wiley   +1 more source

Bilateral Ophthalmoplegia After Neoadjuvant Pembrolizumab for Oral Cavity Squamous Cell Carcinoma

open access: yesThe Laryngoscope, EarlyView.
The role of immune checkpoint inhibition (ICI) therapy in the treatment of head and neck squamous cell carcinoma (HNSCC) is expanding with increased utilization of neoadjuvant and adjuvant pembrolizumab in the setting of locally advanced disease. This report describes the presentation and management of the first known case of pembrolizumab‐induced ...
Leonard E. Estephan   +3 more
wiley   +1 more source

Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma

open access: yesThe Laryngoscope, EarlyView.
We investigated the mutational landscape and prognostic implications of recurrent/metastatic papillary thyroid carcinoma using nationwide C‐CAT data from 348 patients. CDKN2A, KMT2D, and concurrent TERT/BRAF mutations were independently associated with poorer overall survival, highlighting the potential prognostic value of comprehensive genomic ...
Hiromi Nagano   +3 more
wiley   +1 more source

Radiofrequency Ablation as a Safe and Effective Treatment for Thyroid Nodules After Lobectomy

open access: yesThe Laryngoscope, EarlyView.
ABSTRACT Background A new symptomatic nodule may develop or a preexisting nodule may grow to warrant treatment in the remaining lobe of patients who previously had a unilateral thyroid lobectomy. Conventional management often results in completion thyroidectomy, but radiofrequency ablation (RFA) offers a minimally invasive alternative to surgical ...
Yaser Bashumeel   +11 more
wiley   +1 more source

Visual Parathyroid Identification in Thyroidectomy: A Decision Curve Analysis of Gland Preservation

open access: yesThe Laryngoscope, EarlyView.
Intraoperative visual identification remains the standard approach to parathyroid preservation during thyroidectomy, yet its accuracy has rarely been quantified against an objective reference. Among 50 suspected parathyroid specimens verified by fine‐needle aspiration PTH washout, expert consensus visual identification achieved 84.0% sensitivity but ...
Paveena Pithuksurachai   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy