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Main Factors Involved in Thyroid Hormone Action

Molecules, 2021
The thyroid hormone receptors are the mediators of a multitude of actions by the thyroid hormones in cells. Most thyroid hormone activities require interaction with nuclear receptors to bind DNA and regulate the expression of target genes. In addition to
Lorena Tedeschi, Cristina Vassalle, Giorgio Iervasi, Laura Sabatino   +3 more
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Graves’ disease coexisted with resistance to thyroid hormone: a case report

Journal of Medical Case Reports, 2021
Background Resistance to thyroid hormone is a rare autosomal dominant disorder characterized by reduced responsiveness to thyroid hormone and can cause syndrome of inappropriate secretion of thyroid stimulating hormone.
Hiroshi Akahori, Rika Usuda
doaj   +1 more source

Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance

Endocrine Connections, 2022
Background: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone recepto r β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly ...
Marcus Heldmann, Krishna Chatterjee, Carla Moran, Berenike Rogge, Julia Steinhardt, Tobias Wagner-Altendorf, Martin Göttlich, Hannes Schacht, Peter Schramm, Georg Brabant, Thomas F Münte, Anna Cirkel   +11 more
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Impact of TPOAb-negative maternal subclinical hypothyroidism in early pregnancy on adverse pregnancy outcomes

Therapeutic Advances in Endocrinology and Metabolism, 2021
Purpose: To investigate the effect of subclinical hypothyroidism on pregnancy outcomes of women early in their pregnancy with different thyroid-stimulating hormone levels and thyroid peroxidase antibody–negative status and to explore reasonable thyroid ...
Ping Zhu, Ruifeng Chu, Shilei Pan, Xiaolan Lai, Jianmin Ran, Xiuhong Li   +5 more
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Sensitivity to thyroid hormone indices are associated with papillary thyroid carcinoma in Chinese patients with thyroid nodules

BMC Endocrine Disorders, 2023
Background The association between thyroid hormone sensitivity and thyroid cancer is unknown, and we aimed to investigate the association between sensitivity to thyroid hormone indices and papillary thyroid carcinoma (PTC) in Chinese patients with ...
Jie Sun, Jie Liu, Ting-ting Wu, Zhi-yuan Gu, Xiao-wen Zhang   +4 more
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Iodine deficiency is associated with increased thyroid hormone sensitivity in individuals with elevated TSH

European Thyroid Journal, 2023
Objective: Central sensitivity of thyroid hormone refers to the sensitivity of hypothalamic– pituitary–thyroid (HPT) axis to the change in circulating free thyroxine (fT4).
Ying Sun, Di Teng, Lei Zhao, Xiaoguang Shi, Yongze Li, Zhongyan Shan, Weiping Teng   +6 more
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Role of hepatic deiodinases in thyroid hormone homeostasis and liver metabolism, inflammation, and fibrosis

European Thyroid Journal, 2023
Thyroid hormones play an essential role in regulating whole-body homeostasis. Deiodinases are known to convert thyroid hormone from the prohormone thyroxine (T4) to the bioactive hormone tri-iodothyronine (T3) and convert both T4 and T3 toward their ...
Eveline Bruinstroop, Anne H van der Spek, Anita Boelen   +2 more
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Mathematical modeling and simulation of thyroid homeostasis: Implications for the Allan-Herndon-Dudley syndrome

Frontiers in Endocrinology, 2022
IntroductionA mathematical model of the pituitary-thyroid feedback loop is extended to deepen the understanding of the Allan-Herndon-Dudley syndrome (AHDS). The AHDS is characterized by unusual thyroid hormone concentrations and a mutation in the SLC16A2
Tobias M. Wolff, Carina Veil, Johannes W. Dietrich, Johannes W. Dietrich, Johannes W. Dietrich, Matthias A. Müller   +5 more
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A negative correlation of thyroid stimulating hormone with anti_mullerian hormone and with luteinizing hormone in polycystic ovary syndrome and/or hypothyroid women

Middle East Fertility Society Journal, 2018
Background: Using anti_mullerian hormone (AMH) for Polycystic Ovary Syndrome diagnosis is not always constant. Thyroid dysfunction may effect on AMH levels.
Samal Hakeem Kareem AL-Jaff
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Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation. [PDF]

PLoS ONE, 2014
Thyroid hormone entry into cells is facilitated by transmembrane transporters. Mutations of the specific thyroid hormone transporter, MCT8 (Monocarboxylate Transporter 8, SLC16A2) cause an X-linked syndrome of profound neurological impairment and altered
Bárbara Núñez, Raquel Martínez de Mena, Maria Jesus Obregon, Mariona Font-Llitjós, Virginia Nunes, Manuel Palacín, Alexandra M Dumitrescu, Beatriz Morte, Juan Bernal   +8 more
doaj   +1 more source