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Functional role of THRAP3 in modulating thyroid hormone-mediated gene networks in C2C12 myotubes. [PDF]

PLoS ONE
Thyroid hormone (TH) secreted by the thyroid gland plays essential roles in regulating metabolism, development, and nervous system function. Thyroid hormone receptor-associated protein 3 (THRAP3) is a nuclear coactivator that interacts with the thyroid ...
Taku Fukushima, Sachi Kuse, Yuka Hasegawa, Taiju Fujioka, Takeshi Nikawa, Satoru Masubuchi, Iori Sakakibara   +6 more
doaj   +2 more sources

Main Factors Involved in Thyroid Hormone Action

Molecules, 2021
The thyroid hormone receptors are the mediators of a multitude of actions by the thyroid hormones in cells. Most thyroid hormone activities require interaction with nuclear receptors to bind DNA and regulate the expression of target genes. In addition to
Lorena Tedeschi, Cristina Vassalle, Giorgio Iervasi, Laura Sabatino   +3 more
doaj   +1 more source

Graves’ disease coexisted with resistance to thyroid hormone: a case report

Journal of Medical Case Reports, 2021
Background Resistance to thyroid hormone is a rare autosomal dominant disorder characterized by reduced responsiveness to thyroid hormone and can cause syndrome of inappropriate secretion of thyroid stimulating hormone.
Hiroshi Akahori, Rika Usuda
doaj   +1 more source

A Case of Thyroid Hormone Resistance Syndrome with a Novel Mutation (c.947G>a) in the THRB Gene: Experience in Diagnosis and Treatment

International Medical Case Reports Journal
Jie Liu, Yu Wei, Yanhui Zhu, Yu Li, Qiong Wang, Lei Yu, Langen Zhuang, Guoxi Jin, Xiaoyan Pei Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui Province, People’s Republic of ChinaCorrespondence: Guoxi
Liu J, Wei Y, Zhu Y, Li Y, Wang Q, Yu L, Zhuang L, Jin G, Pei X   +8 more
doaj   +2 more sources

Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance

Endocrine Connections, 2022
Background: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone recepto r β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly ...
Marcus Heldmann, Krishna Chatterjee, Carla Moran, Berenike Rogge, Julia Steinhardt, Tobias Wagner-Altendorf, Martin Göttlich, Hannes Schacht, Peter Schramm, Georg Brabant, Thomas F Münte, Anna Cirkel   +11 more
doaj   +1 more source

Impact of TPOAb-negative maternal subclinical hypothyroidism in early pregnancy on adverse pregnancy outcomes

Therapeutic Advances in Endocrinology and Metabolism, 2021
Purpose: To investigate the effect of subclinical hypothyroidism on pregnancy outcomes of women early in their pregnancy with different thyroid-stimulating hormone levels and thyroid peroxidase antibody–negative status and to explore reasonable thyroid ...
Ping Zhu, Ruifeng Chu, Shilei Pan, Xiaolan Lai, Jianmin Ran, Xiuhong Li   +5 more
doaj   +1 more source

Sensitivity to thyroid hormone indices are associated with papillary thyroid carcinoma in Chinese patients with thyroid nodules

BMC Endocrine Disorders, 2023
Background The association between thyroid hormone sensitivity and thyroid cancer is unknown, and we aimed to investigate the association between sensitivity to thyroid hormone indices and papillary thyroid carcinoma (PTC) in Chinese patients with ...
Jie Sun, Jie Liu, Ting-ting Wu, Zhi-yuan Gu, Xiao-wen Zhang   +4 more
doaj   +1 more source

Iodine deficiency is associated with increased thyroid hormone sensitivity in individuals with elevated TSH

European Thyroid Journal, 2023
Objective: Central sensitivity of thyroid hormone refers to the sensitivity of hypothalamic– pituitary–thyroid (HPT) axis to the change in circulating free thyroxine (fT4).
Ying Sun, Di Teng, Lei Zhao, Xiaoguang Shi, Yongze Li, Zhongyan Shan, Weiping Teng   +6 more
doaj   +1 more source

Role of hepatic deiodinases in thyroid hormone homeostasis and liver metabolism, inflammation, and fibrosis

European Thyroid Journal, 2023
Thyroid hormones play an essential role in regulating whole-body homeostasis. Deiodinases are known to convert thyroid hormone from the prohormone thyroxine (T4) to the bioactive hormone tri-iodothyronine (T3) and convert both T4 and T3 toward their ...
Eveline Bruinstroop, Anne H van der Spek, Anita Boelen   +2 more
doaj   +1 more source

Mathematical modeling and simulation of thyroid homeostasis: Implications for the Allan-Herndon-Dudley syndrome

Frontiers in Endocrinology, 2022
IntroductionA mathematical model of the pituitary-thyroid feedback loop is extended to deepen the understanding of the Allan-Herndon-Dudley syndrome (AHDS). The AHDS is characterized by unusual thyroid hormone concentrations and a mutation in the SLC16A2
Tobias M. Wolff, Carina Veil, Johannes W. Dietrich, Johannes W. Dietrich, Johannes W. Dietrich, Matthias A. Müller   +5 more
doaj   +1 more source