Results 151 to 160 of about 2,380,315 (334)

A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562. [PDF]

, 1985
A subpopulation of low density granular lymphocytes that express the natural killer (NK) cell-associated Leu-11 antigen (IgG Fc receptor) were stimulated directly by coculture with an NK-sensitive tumor cell, K562.
Lanier, LL, Phillips, JH
core  

Lysosome‐Featured Cell Aggregate‐Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post‐Irradiation Endothelial Ferroptosis for Mandibular Regeneration

Advanced Science, EarlyView.
Lysosomal redistribution occurs via extracellular vesicles in multi‐stem cell aggregates and controls iron homeostasis for safeguarding cell aggregation. These cell aggregate‐released extracellular vesicles (CA‐EVs) rescue lysosomal impairments and exert anti‐ferroptosis effects in recipient irradiated endothelial cells.
Yuan‐Yuan Li, Bo Ma, Jia‐Wei Lu, Kai‐Chao Zhang, Chao Ma, Sheng‐Feng Bai, Yan‐Jiao Li, Si‐Qi Ying, Wei‐Zong Weng, Kai Zhang, Xi‐Wang Hu, Rang Li, Chen‐Xi Zheng, Xiao‐Ru Xu, Ji Chen, Fang Jin, Hao‐Kun Xu, Jian‐Wei Xie, Yan Jin, Yi Shuai, Bing‐Dong Sui   +20 more
wiley   +1 more source

Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease

Advanced Science, EarlyView.
In this study, an adaptive antioxidant nanodrug (AAN) is developed through the self‐polymerization of L‐selenocysteine. The AAN exhibits dual functionalities: antioxidant activity (scavenging reactive oxygen species) and mitochondrial targeting. Moreover, the released selenium (Se) participates in the synthesis of glutathione peroxidase 4 (GPX4), which
Zerun Liu, Ting Huang, Ying Hong, Yuqi Yang, Wensheng Chen, Qingtao Zeng, Qiaohui Chen, Yongqi Yang, Xiaohong Ying, Wan Zeng, Ziyu Wu, Tianjiao Zhao, Xuesi Wan, Jianlin Chen, Kelong Ai, Qiong Huang   +15 more
wiley   +1 more source

Developing Biomaterial‐Based mRNA Delivery System for Lung Disease Treatment

Advanced Science, EarlyView.
Schematic illustration of biomaterial delivery mRNA for the treatment of lung diseases. Abstract Lung disease remains a persistent global health challenge. Advances in medical research have led to innovative strategies to combat these conditions, with biomaterials emerging as a promising platform for targeted drug delivery.
Qiancheng Gu, Huaqian Xue, Zhiyun Liu, Jiameng Rao, Lingyao Zeng, Chen Zhang, Lanjie Lei, Liyun Shi   +7 more
wiley   +1 more source

Pulmonary delivery of transferrin receptors targeting peptide surface-functionalized liposomes augments the chemotherapeutic effect of quercetin in lung cancer therapy

International Journal of Nanomedicine, 2019
Muhammad Kashif Riaz,1 Xue Zhang,1 Ka Hong Wong,1 Huoji Chen,2 Qiang Liu,2 Xiaoyu Chen,1 Ge Zhang,1 Aiping Lu,1,3 Zhijun Yang1,31School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, People’s Republic of China; 2School of Traditional
Riaz MK, Zhang X, Wong KH, Chen H, Liu Q, Chen X, Zhang G, Lu A, Yang Z   +8 more
doaj  

Characterization of a continuous feline mammary epithelial cell line susceptible to feline epitheliotropic viruses. [PDF]

, 2009
Mucosal epithelial cells are the primary targets for many common viral pathogens of cats. Viral infection of epithelia can damage or disrupt the epithelial barrier that protects underlying tissues.
Heymer, Anna, Liu, Hongwei, Millon, Lee, Ossiboff, Robert J, Parker, John SL, Pesavento, Patricia, Stucker, Karla M, van der List, Deborah, Wood, Jason   +8 more
core  

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Advanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au   +16 more
wiley   +1 more source

DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases

Nature Communications
Oligonucleotide-based medicine faces challenges in efficiently crossing the blood-brain barrier and rapidly reducing toxic proteins. To address these challenges, here we establish an integrated modality, brain-penetrant DNA nanoflowers incorporated with ...
Ruixin Ge, Miao Chen, Sijin Wu, Sirui Huang, Ping Zhou, Minghui Cao, Fan Zhang, Jinzhi Zang, Yigao Zhu, Jingrui Li, Guilin Ni, Zhihao Yang, Qingchao Li, Wei Pan, Liang Zhang, Min Liu, Chenghao Xuan, Haiyang Yu, Jun Zhou, Songbo Xie   +19 more
doaj   +1 more source

Effects of blood withdrawal and reinfusion on biomarkers of erythropoiesis in humans: Implications for anti-doping strategies [PDF]

, 2006
To discriminate autologous blood doping procedures from normal conditions, we examined the hematological response to blood withdrawal and reinfusion. We found that biomarkers of erythropoiesis are primarily affected in the anemic period.
Damsgaard, R, González-Alonso, J, Mortensen, SP, Munch, T, Mørkeberg, J   +4 more
core  

Half‐Pipe Melt Electrowritten Scaffolds Support Engineering of an Immunocompetent Hydrogel‐Embedded Intestine‐on‐a‐Chip

Advanced Science, EarlyView.
The immunocompetent Intestine‐on‐a‐Chip (IoC) is developed using melt electrowritten (MEW) half‐pipes. Intestinal epithelial cell (IEC) culture is optimized in the MEW‐based IoC, followed by co‐culture with monocyte‐derived dendritic cells (moDCs) and T cells in 3D hydrogels.
Robine Janssen, Henrike S. Schulze, Claire M. L. Nelissen, Marta G. Valverde, Andrei Hrynevich, Govardus A. H. de Jong, Anne Metje van Genderen, Jos Malda, Shanna Bastiaan‐Net, Linette E. M. Willemsen, Rosalinde Masereeuw   +10 more
wiley   +1 more source