Results 71 to 80 of about 2,380,315 (334)

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Soluble transferrin receptor and immature reticulocytes are not useful for distinguishing iron-deficiency anemia from heterozygous beta-thalassemia

São Paulo Medical Journal
Iron deficiency and heterozygous beta-thalassemia are important causes of hypochromic-microcytic anemia. Two laboratory parameters are suggested for the differentiation of such anemia.
Gisélia Aparecida Freire Maia de Lima, Helena Zerlotti Wolf Grotto   +1 more
doaj   +1 more source

Protein Kinase B Stimulates the Translocation of GLUT4 but Not GLUT1 or Transferrin Receptors in 3T3-L1 Adipocytes by a Pathway Involving SNAP-23, Synaptobrevin-2, and/or Cellubrevin*

Journal of Biological Chemistry, 1999
An interaction of SNAP-23 and syntaxin 4 on the plasma membrane with vesicle-associated synaptobrevin-2 and/or cellubrevin, known as SNAP (soluble N -ethyl-maleimide-sensitive factorattachment protein) receptors or SNAREs, has been proposed to provide ...
P. Foran, L. Fletcher, P. Oatey, N. Mohammed, J. Dolly, J. Tavaré   +5 more
semanticscholar   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding.

PLoS ONE, 2014
We have adapted an in vitro model of the human blood-brain barrier, the immortalized human cerebral microvascular endothelial cells (hCMEC/D3), to quantitatively measure protein transcytosis.
Hadassah Sade, Claudia Baumgartner, Adrian Hugenmatter, Ekkehard Moessner, Per-Ola Freskgård, Jens Niewoehner   +5 more
doaj   +1 more source

Acute inactivation of PSD-95 destabilizes AMPA receptors at hippocampal synapses. [PDF]

PLoS ONE, 2013
Postsynatptic density protein (PSD-95) is a 95 kDa scaffolding protein that assembles signaling complexes at synapses. Over-expression of PSD-95 in primary hippocampal neurons selectively increases synaptic localization of AMPA receptors; however, mice ...
Guillermo A Yudowski, Olav Olsen, Hillel Adesnik, Kurt W Marek, David S Bredt   +4 more
doaj   +1 more source

Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins. [PDF]

, 2019
Dinoflagelates and cyanobacteria produce saxitoxin (STX), a lethal bis-guanidinium neurotoxin causing paralytic shellfish poisoning. A number of metazoans have soluble STX-binding proteins that may prevent STX intoxication.
Du Bois, J, Lolicato, Marco, Minor, Daniel L, Thomas-Tran, Rhiannon, Yen, Tien-Jui   +4 more
core   +2 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Lactoferrin. A natural glycoprotein involved in iron and inflammatory homeostasis [PDF]

, 2017
Human lactoferrin (hLf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, is a key element of host defenses.
Cutone, Antimo, Lepanto, Maria Stefania, Paesano, Rosalba, Rosa, Luigi, Valenti, Piera   +4 more
core   +2 more sources

Newly Synthesized Transferrin Receptors Can Be Detected in the Endosome before They Appear on the Cell Surface (*)

Journal of Biological Chemistry, 1995
It is well established that a proportion of newly synthesized lysosomal enzymes and class II major histocompatibility complex antigens are delivered directly to the endocytic pathway from the Golgi complex.
C. Futter, C. Connolly, D. Cutler, C. Hopkins   +3 more
semanticscholar   +1 more source