Results 81 to 90 of about 52,419 (262)

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Special status of iron transfer proteins in the serum of breast cancer patients

Discover Oncology
Cancer cells have a greater requirement for iron because of their continuous and rapid proliferation. To do that, iron homeostasis is altered in cancer cells to meet this excessive demand.
Lama Alhaddad, Maher Saifo, Ranwa Alsayed   +2 more
doaj   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Correlation between maternal hemoglobin and serum transferrin receptor with lactoferrin concentration in breastfeeding mothers

Family Medicine & Primary Care Review, 2021
Mohammad Zen Rahfiludin, Dina Rahayuning Pangestuti, Suyatno Suyatno, Suroto Suroto   +3 more
doaj   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

Advanced Science, EarlyView.
A mitochondrial‐targeted FeCD‐SS31 nanoplatform integrates ROS‐responsive SS31 release with cascade antioxidant Fe3O4/CDs cores to suppress both de novo and existing ROS. By restoring mitochondrial complex integrity and blocking caspase‐1–GSDMD‐N pyroptosis, it reduces neutrophil infiltration and alleviates hepatic ischemia–reperfusion injury, while ...
Qianying Du, Lian Xu, Tingting Xia, Wenli Zhang, Sijin Chen, Xiyue Rong, Ying Luo, Yi Wang, Jia Liu, Yun Liu, Haitao Ran, Dajing Guo, Jie Xu   +12 more
wiley   +1 more source

In Situ Regulation of Protein Corona for Enhanced Tumor-targeted 19F MRI and Combined Therapy

Chinese Journal of Magnetic Resonance
This study designed and constructed a pH-responsive intelligent theranostic nanoprobe. The nanoprobe utilizes perfluorocarbon nanoparticles with 19F magnetic resonance imaging (MRI) contrast capability as the core, with bovine serum albumin (BSA ...
LI Ruiyi, LI Sha, XU Qiuyi, SUI Meiju, CHEN Shizhen   +4 more
doaj   +1 more source

Preoperative Total Iron‐Binding Capacity Is a Potential Surrogate Marker of Long‐Term Outcomes After Pancreatectomy for Pancreatic Cancer

Annals of Gastroenterological Surgery, EarlyView.
Preoperative low serum total iron‐binding capacity (TIBC) was associated with poorer overall survival and recurrence‐free survival after pancreatectomy for pancreatic cancer. These findings suggest that preoperative serum TIBC may serve as a simple surrogate marker for long‐term outcomes in patients undergoing pancreatectomy.
Taishi Yamane, Hiromitsu Hayashi, Hiroshi Sawayama, Takashi Matsumoto, Toru Takematsu, Takanobu Yamao, Yuki Kitano, Tatsunori Miyata, Hirohisa Okabe, Masaaki Iwatsuki   +9 more
wiley   +1 more source

Tracking hemopexin intracellularly and defining hemopexin protein “interactomes” in human immune and liver cell models

Frontiers in Physiology
Maintaining hemopexin (HPX) plasma levels protects against heme-activated inflammation as well as the toxicity of heme and its iron during hemolysis. Plasma heme regulates HPX turnover in hepatocytes, thus controlling plasma HPX concentration.
Bryan Rose, David Moore, Jeff Eskew, Roberto Vanacore, Steve D. Hartson, Dennis Province, D. Andrew Skaff, Ann Smith   +7 more
doaj   +1 more source

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Ugo Boccadifuoco, Ivan Lerner, Auria Godard, Luc Darnige, Laure Joseph, Wassim El Nemer, Geoffrey Cheminet, Jean‐Benoit Arlet   +7 more
wiley   +1 more source