Results 1 to 10 of about 81,753 (161)

Modulation of transferrin receptor by HIV-2 [PDF]

Virology Journal
Background Human immunodeficiency viruses (HIV-1 and HIV-2), are the causative agents of the acquired immunodeficiency syndrome (AIDS), that share substantial genomic and structural similarities, yet differ in replication dynamics and disease progression.
Aya Shamal Al-Muffti, Irene Wanjiru Kiarie, József Tőzsér, Mohamed Mahdi   +3 more
doaj   +2 more sources

Investigation of Trends in the Research on Transferrin Receptor-Mediated Drug Delivery via a Bibliometric and Thematic Analysis

Pharmaceutics, 2022
This study systematically reviews and characterizes the existing literature on transferrin/transferrin receptor-mediated drug delivery. Transferrin is an iron-binding protein. It can be used as a ligand to deliver various proteins, genes, ions, and drugs
Tarnjot Kaur, Jyoti Upadhyay, Sudeep Pukale, Ashish Mathur, Mohd Nazam Ansari   +4 more
doaj   +1 more source

Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate. [PDF]

PLoS ONE, 2018
One of the major drawbacks of many of the currently used cancer drugs are off-target effects. Targeted delivery is one method to minimize such unwanted and detrimental events.
Manoj Saxena, Yamixa Delgado, Rohit Kumar Sharma, Shweta Sharma, Solimar Liz Ponce De León Guzmán, Arthur D Tinoco, Kai Griebenow   +6 more
doaj   +1 more source

RELATIONSHIP OF CHANGES IN HEMATOLOGICAL AND BIOCHEMICAL INDICATORS OF PERIPHERAL BLOOD WITH THE TRANSFERRIN CONCENTRATION AND CD71+ LYMPHOCYTE COUNT

Siberian Journal of Life Sciences and Agriculture, 2022
Transferrin is an essential component of cell growth and metabolic processes that require iron. An increase in the expression of transferrin receptors on lymphocytes ensures their differentiation, maturation and activation of proliferation.
Veronika V. Patrakeeva, Liliya K. Dobrodeeva, Natal’ya P. Geshavec   +2 more
doaj   +1 more source

Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1. [PDF]

PLoS ONE, 2012
Artemisinin and its main active metabolite dihydroartemisinin, clinically used antimalarial agents with low host toxicity, have recently shown potent anticancer activities in a variety of human cancer models.
Qian Ba, Naiyuan Zhou, Juan Duan, Tao Chen, Miao Hao, Xinying Yang, Junyang Li, Jun Yin, Ruiai Chu, Hui Wang   +9 more
doaj   +1 more source

BODY IRON STATUS INDICATORS AND INFLAMMATION INDICATORS DURING INFLAMMATORY BOWEL DISEASE THERAPY IN CHILDREN AND ADOLESCENTES [PDF]

Arquivos de Gastroenterologia, 2021
BACKGROUND: The treatment of patients with inflammatory bowel disease (IBD) consists of the induction and maintenance remission of the disease. Iron status indicators would be useful for the diagnosis of iron deficiency anemia, whereas the inflammation ...
Fernanda F CORRÊA, Vera L SDEPANIAN
doaj   +1 more source

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

Haematologica, 2015
Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.
Alessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, Catherine Lacombe, Patrick Mayeux, Frédérique Verdier, Clara Camaschella, Laura Silvestri   +9 more
doaj   +1 more source

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

BMC Cell Biology, 2010
Background Optineurin is a multifunctional protein involved in several functions such as vesicular trafficking from the Golgi to the plasma membrane, NF-κB regulation, signal transduction and gene expression.
Rangaraj Nandini, Radha Vegesna, Jain Nishant, Chalasani Madhavi L, Nagabhushana Ananthamurthy, Balasubramanian Dorairajan, Swarup Ghanshyam   +6 more
doaj   +1 more source

Identification and in vivo characterization of a brain-penetrating nanobody

Fluids and Barriers of the CNS, 2020
Background Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to
Y Wouters, T Jaspers, B De Strooper, M Dewilde   +3 more
doaj   +1 more source

Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles

Pharmaceutics, 2022
The blood–brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to biologics. Liposomes and other nanoparticles are good candidates for the delivery of biologics across the BECs, as they can encapsulate numerous molecules of ...
Maj Schneider Thomsen, Kasper Bendix Johnsen, Krzysztof Kucharz, Martin Lauritzen, Torben Moos   +4 more
doaj   +1 more source