Results 21 to 30 of about 133,411 (307)

Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles

Pharmaceutics, 2022
The blood–brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to biologics. Liposomes and other nanoparticles are good candidates for the delivery of biologics across the BECs, as they can encapsulate numerous molecules of ...
Maj Schneider Thomsen, Kasper Bendix Johnsen, Krzysztof Kucharz, Martin Lauritzen, Torben Moos   +4 more
doaj   +1 more source

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

Haematologica, 2015
Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.
Alessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, Catherine Lacombe, Patrick Mayeux, Frédérique Verdier, Clara Camaschella, Laura Silvestri   +9 more
doaj   +1 more source

Ferritin, transferrin, and transferrin receptor in relation to metabolic obesity phenotypes: Findings from the China Health and Nutrition Survey

Frontiers in Public Health, 2022
BackgroundThis study aimed to explore the relationship between iron markers and metabolic obesity phenotypes and the role of age.MethodsData were from the China Health and Nutrition Survey 2009. Metabolic obesity phenotypes included metabolically healthy
Ziyang Ren, Xingqi Cao, Chenxi Li, Jingyun Zhang, Xueqin Li, Peige Song, Yimin Zhu, Zuyun Liu   +7 more
doaj   +1 more source

Transferrin-polycation conjugates as carriers for DNA uptake into cells. [PDF]

, 1990
We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated endocytosis to carry DNA macromolecules into cells. We accomplished this by conjugating the iron-transport protein transferrin to polycations that bind nucleic ...
Beug, Hartmut, Birnstiel, Max L., Cotten, Matt, Wagner, Ernst, Zenke, Martin   +4 more
core   +1 more source

Identification and in vivo characterization of a brain-penetrating nanobody

Fluids and Barriers of the CNS, 2020
Background Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to
Y Wouters, T Jaspers, B De Strooper, M Dewilde   +3 more
doaj   +1 more source

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

BMC Cell Biology, 2010
Background Optineurin is a multifunctional protein involved in several functions such as vesicular trafficking from the Golgi to the plasma membrane, NF-κB regulation, signal transduction and gene expression.
Rangaraj Nandini, Radha Vegesna, Jain Nishant, Chalasani Madhavi L, Nagabhushana Ananthamurthy, Balasubramanian Dorairajan, Swarup Ghanshyam   +6 more
doaj   +1 more source

Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting [PDF]

, 2000
PURPOSE: To prepare polymeric vesicles and niosomes bearing glucose or transferrin ligands for drug targeting. METHODS: A glucose-palmitoyl glycol chitosan (PGC) conjugate was synthesised and glucose-PGC polymeric vesicles prepared by sonication of ...
Couet, W., Dufès, Christine, Gray, A.I., Olivier, J.C., Schätzlein, A.G., Tetley, L., Uchegbu, I.F., Watson, D.G.   +7 more
core   +1 more source

Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE [PDF]

, 2000
The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis.
Andrews, Nancy C., Bennett, Melanie J., Bjorkman, Pamela J., Enns, Caroline A., Sellers, Vera M., West, Anthony P., Jr.   +5 more
core   +1 more source

Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation

Haematologica, 2010
Background Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2.
Maura Poli, Sara Luscieti, Valentina Gandini, Federica Maccarinelli, Dario Finazzi, Laura Silvestri, Antonella Roetto, Paolo Arosio   +7 more
doaj   +1 more source

The trypanosomal transferrin receptor of trypanosoma brucei : a review [PDF]

, 2019
Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with mammals evolving a safe and bio-viable means of its transport and storage. This transport and storage is also utilized as part of the
Kariuki, Christopher K., Magez, Stefan, Stijlemans, Benoit   +2 more
core   +2 more sources