Results 11 to 20 of about 81,753 (161)

Transferrin receptors

Experimental and Molecular Medicine
The transferrin receptor (TfR) is one of the key proteins involved in cellular iron uptake. TfR-mediated endocytosis of transferrin-bound iron is the major pathway for iron acquisition by most cells in the body.
Qian Guo, Christopher Qian, Xinyu Wang, Zhong-Ming Qian   +3 more
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Transferrin Receptors in Erythropoiesis [PDF]

International Journal of Molecular Sciences, 2020
Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron-containing hemes.
Richard, Cyrielle, Verdier, Frédérique
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Heterotypic interactions between transferrin receptor and transferrin receptor 2 [PDF]

Blood, 2003
Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR). Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism.
Vogt, Todd M, Blackwell, Aaron D, Giannetti, Anthony M, Bjorkman, Pamela J, Enns, Caroline A   +4 more
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DISTRIBUTION OF TRANSFERRIN AND TRANSFERRIN RECEPTORS IN THE RABBIT PLACENTA [PDF]

Quarterly Journal of Experimental Physiology, 1983
The quantity and distribution of transferrin and transferrin‐binding sites in the placenta were investigated in rabbits on the 28th‐29th days of pregnancy. The animals were injected intravenously with a mixture of 59Fe‐125I‐labelled rabbit diferric transferrin and 131I‐labelled rabbit albumin.
E, Baker, F M, van Bockxmeer, E H, Morgan   +2 more
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Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation

Haematologica, 2010
Background Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2.
Maura Poli, Sara Luscieti, Valentina Gandini, Federica Maccarinelli, Dario Finazzi, Laura Silvestri, Antonella Roetto, Paolo Arosio   +7 more
doaj   +1 more source

Ferritin, transferrin, and transferrin receptor in relation to metabolic obesity phenotypes: Findings from the China Health and Nutrition Survey

Frontiers in Public Health, 2022
BackgroundThis study aimed to explore the relationship between iron markers and metabolic obesity phenotypes and the role of age.MethodsData were from the China Health and Nutrition Survey 2009. Metabolic obesity phenotypes included metabolically healthy
Ziyang Ren, Xingqi Cao, Chenxi Li, Jingyun Zhang, Xueqin Li, Peige Song, Yimin Zhu, Zuyun Liu   +7 more
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Localization of Transferrin and Transferrin Receptors in Rat Testes [PDF]

Biology of Reproduction, 1984
One of the major proteins secreted by rat Sertoli cells in culture is a transferrin-like protein (Skinner and Griswold, 1980). The purpose of this study was to quantitate the amount of testicular transferrin in fluids isolated from the testis by the use of a radioimmunoassay and to determine the location of transferrin and transferrin receptors in the ...
S R, Sylvester, M D, Griswold
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Structure of the Human Transferrin Receptor-Transferrin Complex [PDF]

Cell, 2004
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of
Cheng, Yifan, Zak, Olga, Aisen, Philip, Harrison, Stephen C, Walz, Thomas   +4 more
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An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

Molecular Therapy: Nucleic Acids, 2012
The transferrin receptor, CD71, is an attractive target for drug development because of its high expression on a number of cancer cell lines and the blood brain barrier. To generate serum-stabilized aptamers that recognize the human transferrin receptor,
Samantha E Wilner, Brian Wengerter, Keith Maier, Maria de Lourdes Borba Magalhães, David Soriano Del Amo, Supriya Pai, Felipe Opazo, Silvio O Rizzoli, Amy Yan, Matthew Levy   +9 more
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Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool

Tumor Biology, 2017
Labile iron pool is a cellular source of ions available for Fenton reactions resulting in oxidative stress. Living organisms avoid an excess of free irons by a tight control of iron homeostasis.
Wassana Jamnongkan, Raynoo Thanan, Anchalee Techasen, Nisana Namwat, Watcharin Loilome, Piyapharom Intarawichian, Attapol Titapun, Puangrat Yongvanit   +7 more
doaj   +1 more source