Results 11 to 20 of about 78,269 (261)

Modulation of transferrin receptor by HIV-2 [PDF]

Virology Journal
Background Human immunodeficiency viruses (HIV-1 and HIV-2), are the causative agents of the acquired immunodeficiency syndrome (AIDS), that share substantial genomic and structural similarities, yet differ in replication dynamics and disease progression.
Aya Shamal Al-Muffti, Irene Wanjiru Kiarie, József Tőzsér, Mohamed Mahdi   +3 more
doaj   +2 more sources

Identification and in vivo characterization of a brain-penetrating nanobody

Fluids and Barriers of the CNS, 2020
Background Preclinical models to determine blood to brain transport ability of therapeutics are often ambiguous. In this study a method is developed that relies on CNS target-engagement and is able to rank brain-penetrating capacities. This method led to
Y Wouters, T Jaspers, B De Strooper, M Dewilde   +3 more
doaj   +1 more source

Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles

Pharmaceutics, 2022
The blood–brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to biologics. Liposomes and other nanoparticles are good candidates for the delivery of biologics across the BECs, as they can encapsulate numerous molecules of ...
Maj Schneider Thomsen, Kasper Bendix Johnsen, Krzysztof Kucharz, Martin Lauritzen, Torben Moos   +4 more
doaj   +1 more source

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

BMC Cell Biology, 2010
Background Optineurin is a multifunctional protein involved in several functions such as vesicular trafficking from the Golgi to the plasma membrane, NF-κB regulation, signal transduction and gene expression.
Rangaraj Nandini, Radha Vegesna, Jain Nishant, Chalasani Madhavi L, Nagabhushana Ananthamurthy, Balasubramanian Dorairajan, Swarup Ghanshyam   +6 more
doaj   +1 more source

Localization of Transferrin and Transferrin Receptors in Rat Testes [PDF]

Biology of Reproduction, 1984
One of the major proteins secreted by rat Sertoli cells in culture is a transferrin-like protein (Skinner and Griswold, 1980). The purpose of this study was to quantitate the amount of testicular transferrin in fluids isolated from the testis by the use of a radioimmunoassay and to determine the location of transferrin and transferrin receptors in the ...
S R, Sylvester, M D, Griswold
openaire   +2 more sources

Ferritin, transferrin, and transferrin receptor in relation to metabolic obesity phenotypes: Findings from the China Health and Nutrition Survey

Frontiers in Public Health, 2022
BackgroundThis study aimed to explore the relationship between iron markers and metabolic obesity phenotypes and the role of age.MethodsData were from the China Health and Nutrition Survey 2009. Metabolic obesity phenotypes included metabolically healthy
Ziyang Ren, Xingqi Cao, Chenxi Li, Jingyun Zhang, Xueqin Li, Peige Song, Yimin Zhu, Zuyun Liu   +7 more
doaj   +1 more source

DISTRIBUTION OF TRANSFERRIN AND TRANSFERRIN RECEPTORS IN THE RABBIT PLACENTA [PDF]

Quarterly Journal of Experimental Physiology, 1983
The quantity and distribution of transferrin and transferrin‐binding sites in the placenta were investigated in rabbits on the 28th‐29th days of pregnancy. The animals were injected intravenously with a mixture of 59Fe‐125I‐labelled rabbit diferric transferrin and 131I‐labelled rabbit albumin.
E, Baker, F M, van Bockxmeer, E H, Morgan   +2 more
openaire   +2 more sources

Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation

Haematologica, 2010
Background Impaired regulation of hepcidin in response to iron is the cause of genetic hemochromatosis associated with defects of HFE and transferrin receptor 2.
Maura Poli, Sara Luscieti, Valentina Gandini, Federica Maccarinelli, Dario Finazzi, Laura Silvestri, Antonella Roetto, Paolo Arosio   +7 more
doaj   +1 more source

Structure of the Human Transferrin Receptor-Transferrin Complex [PDF]

Cell, 2004
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of
Cheng, Yifan, Zak, Olga, Aisen, Philip, Harrison, Stephen C, Walz, Thomas   +4 more
openaire   +2 more sources

An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells

Molecular Therapy: Nucleic Acids, 2012
The transferrin receptor, CD71, is an attractive target for drug development because of its high expression on a number of cancer cell lines and the blood brain barrier. To generate serum-stabilized aptamers that recognize the human transferrin receptor,
Samantha E Wilner, Brian Wengerter, Keith Maier, Maria de Lourdes Borba Magalhães, David Soriano Del Amo, Supriya Pai, Felipe Opazo, Silvio O Rizzoli, Amy Yan, Matthew Levy   +9 more
doaj   +1 more source