Results 1 to 10 of about 49,901 (162)
Experimental and Molecular MedicineThe transferrin receptor (TfR) is one of the key proteins involved in cellular iron uptake. TfR-mediated endocytosis of transferrin-bound iron is the major pathway for iron acquisition by most cells in the body.
Qian Guo +3 more
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Tracking hemopexin intracellularly and defining hemopexin protein “interactomes” in human immune and liver cell models [PDF]
Frontiers in PhysiologyMaintaining hemopexin (HPX) plasma levels protects against heme-activated inflammation as well as the toxicity of heme and its iron during hemolysis. Plasma heme regulates HPX turnover in hepatocytes, thus controlling plasma HPX concentration.
Bryan Rose +7 more
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Transferrin Receptors in Erythropoiesis [PDF]
International Journal of Molecular Sciences, 2020 Erythropoiesis is a highly dynamic process giving rise to red blood cells from hematopoietic stem cells present in the bone marrow. Red blood cells transport oxygen to tissues thanks to the hemoglobin comprised of α- and β-globin chains and of iron-containing hemes.
Richard, Cyrielle, Verdier, Frédérique
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Pharmaceutics, 2022 This study systematically reviews and characterizes the existing literature on transferrin/transferrin receptor-mediated drug delivery. Transferrin is an iron-binding protein. It can be used as a ligand to deliver various proteins, genes, ions, and drugs
Tarnjot Kaur +4 more
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Specific parameters of iron metabolism in tuberculosis
Туберкулез и болезни лёгких, 2021 The review presents data from 55 publications about specific parameters of iron metabolism in the human body including those ill with tuberculosis. It describes processes aimed at isolating iron from pathogens and promoting the acquisition of iron by ...
R. Yu. Аbdullаev +2 more
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Fluids and Barriers of the CNS, 2023 Here, we report an experimental setup to benchmark different receptors for targeted therapeutic antibody delivery at the blood–brain barrier. We used brain capillary endothelial-like cells derived from induced pluripotent stem cells (hiPSC-BECs) as a ...
Mikkel Roland Holst +12 more
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Quantum Dots Encapsulated with Canine Parvovirus-Like Particles Improving the Cellular Targeted Labeling. [PDF]
PLoS ONE, 2015 Quantum dots (QDs) have a promising prospect in live-cell imaging and sensing because of unique fluorescence features. QDs aroused significant interest in the bio-imaging field through integrating the fluorescence properties of QDs and the delivery ...
Dan Yan +7 more
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Transferrin receptor-mediated internalization and intracellular fate of conjugates of a DNA aptamer
Molecular Therapy: Nucleic Acids, 2022 Aptamers have excellent specificity and affinity in targeting cell surface receptors, showing great potential in targeted delivery of drugs, siRNA, mRNA, and various nanomaterials with therapeutic function.
Nan Zhang +4 more
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Journal of Experimental Nanoscience, 2020 With the goal of developing a new type of boron neutron capture therapy (BNCT) agent, selective internalisation of submicrometer boron carbide spherical particles into cancer cells via surface transferrin conjugation is demonstrated and confirmed in ...
Takuma Tsuji +5 more
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Siberian Journal of Life Sciences and Agriculture, 2022 Transferrin is an essential component of cell growth and metabolic processes that require iron. An increase in the expression of transferrin receptors on lymphocytes ensures their differentiation, maturation and activation of proliferation.
Veronika V. Patrakeeva +2 more
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