Results 1 to 10 of about 52,419 (262)

Insights from targeting transferrin receptors to develop vaccines for pathogens of humans and food production animals

Frontiers in Cellular and Infection Microbiology, 2023
While developing vaccines targeting surface transferrin receptor proteins in Gram-negative pathogens of humans and food production animals, the common features derived from their evolutionary origins has provided us with insights on how improvements ...
Nikolas F. Ewasechko, Somshukla Chaudhuri, Anthony B. Schryvers, Anthony B. Schryvers   +3 more
doaj   +1 more source

Investigation into the Antigenic Properties and Contributions to Growth in Blood of the Meningococcal Haemoglobin Receptors, HpuAB and HmbR. [PDF]

PLoS ONE, 2015
Acquisition of iron from host complexes is mediated by four surface-located receptors of Neisseria meningitidis. The HmbR protein and heterodimeric HpuAB complex bind to haemoglobin whilst TbpBA and LbpBA bind iron-loaded transferrin and lactoferrin ...
Fadil A Bidmos, Hannah Chan, Uta Praekelt, Isfahan Tauseef, Youssif M Ali, Edward B Kaczmarski, Ian Feavers, Christopher D Bayliss   +7 more
doaj   +1 more source

Influence of the genetic makeup of common carp on the expression of iron-related genes during Trypanoplasma borreli infection

Journal of Veterinary Research, 2018
Genes related to iron metabolism play an important role in inflammatory response. The objective of this study was to investigate the role of ferritin, transferrin receptors 1a and 1b, and transferrin genes in the response to blood parasite infection in ...
Kamińska-Gibas Teresa, Irnazarow Ilgiz, Szczygieł Joanna, Jurecka Patrycja   +3 more
doaj   +1 more source

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

Haematologica, 2015
Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.
Alessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, Catherine Lacombe, Patrick Mayeux, Frédérique Verdier, Clara Camaschella, Laura Silvestri   +9 more
doaj   +1 more source

Factors associated with iron deficiency in heart failure

Кардиоваскулярная терапия и профилактика, 2023
Aim. To establish the factors associated with iron deficiency (ID) in pa- tients with heart failure (HF).Material and methods. We examined 294 patients with NYHA class II-IV HF as follows: 213 — with ID, 81 — without ID. All patients underwent a clinical
M. P. Smirnova, P. A. Chizhov
doaj   +1 more source

Macrophage colony-stimulating factor differentially regulates low density lipoprotein and transferrin receptors

Journal of Lipid Research, 2004
Endocytosis mediated by both LDL receptors (LDLRs) and transferrin receptors (TfRs) occurs in clathrin-coated pits and requires specific tyrosine-based internalization sequences located in the cytoplasmic domain of these receptors.
Liqin Du, Steven R. Post
doaj   +1 more source

Some aspects of the transport system of iron metabolism depending on the degree of iron overload syndrome in children with chronic hepatitis B

Детские инфекции (Москва), 2019
Objective: to study the status of markers of the transport system of iron metabolism and the marker profile of HBV infection, depending on the degree of iron overload syndrome in children with chronic hepatitis B.The object of the study were 1 85 ...
F. I. Inoyatova, Kh. M. Kadyrkhodjaeva, G. Z. Inogamova, A. Kh. Akhmedova, N. K. Valieva, F. G. Abdullaeva, N. A. Ikramova   +6 more
doaj   +1 more source

Identification of Transferrin Receptor 1 (TfR1) Overexpressed in Lung Cancer Cells, and Internalization of Magnetic Au-CoFe₂O₄ Core-Shell Nanoparticles Functionalized with Its Ligand in a Cellular Model of Small Cell Lung Cancer (SCLC)

Pharmaceutics, 2022
Lung cancer is, currently, one of the main malignancies causing deaths worldwide. To date, early prognostic and diagnostic markers for small cell lung cancer (SCLC) have not been systematically and clearly identified, so most patients receive standard ...
Rocío Villalobos-Manzo, Emmanuel Ríos-Castro, José Manuel Hernández-Hernández, Goldie Oza, Mauricio A. Medina, José Tapia-Ramírez   +5 more
doaj   +1 more source

Cell-Based, High-Content Screen for Receptor Internalization, Recycling and Intracellular Trafficking

BioTechniques, 2000
A variety of physiologically important receptors are internalized and then recycled back to the plasma membrane by the endocytic recycling compartment. These include the transferrin receptor and many G-protein coupled receptors (GPCRs).
R.N. Ghosh, Y.-T. Chen, R. DeBiasio, R.L. DeBiasio, B.R. Conway, L.K. Minor, K.T. Demarest   +6 more
doaj   +1 more source

Single-Molecule Imaging of Membrane Proteins on Vascular Endothelial Cells

Journal of Lipid and Atherosclerosis, 2023
Transporting substances such as gases, nutrients, waste, and cells is the primary function of blood vessels. Vascular cells use membrane proteins to perform crucial endothelial functions, including molecular transport, immune cell infiltration, and ...
Jiseong Park, Siwoo Jin, Juhee Jang, Daeha Seo   +3 more
doaj   +1 more source