Results 1 to 10 of about 87,840 (306)

Tracking hemopexin intracellularly and defining hemopexin protein “interactomes” in human immune and liver cell models [PDF]

Frontiers in Physiology
Maintaining hemopexin (HPX) plasma levels protects against heme-activated inflammation as well as the toxicity of heme and its iron during hemolysis. Plasma heme regulates HPX turnover in hepatocytes, thus controlling plasma HPX concentration.
Bryan Rose, David Moore, Jeff Eskew, Roberto Vanacore, Steve D. Hartson, Dennis Province, D. Andrew Skaff, Ann Smith   +7 more
doaj   +2 more sources

Special status of iron transfer proteins in the serum of breast cancer patients [PDF]

Discover Oncology
Cancer cells have a greater requirement for iron because of their continuous and rapid proliferation. To do that, iron homeostasis is altered in cancer cells to meet this excessive demand.
Lama Alhaddad, Maher Saifo, Ranwa Alsayed   +2 more
doaj   +2 more sources

Investigation of Trends in the Research on Transferrin Receptor-Mediated Drug Delivery via a Bibliometric and Thematic Analysis

Pharmaceutics, 2022
This study systematically reviews and characterizes the existing literature on transferrin/transferrin receptor-mediated drug delivery. Transferrin is an iron-binding protein. It can be used as a ligand to deliver various proteins, genes, ions, and drugs
Tarnjot Kaur, Jyoti Upadhyay, Sudeep Pukale, Ashish Mathur, Mohd Nazam Ansari   +4 more
doaj   +1 more source

Specific parameters of iron metabolism in tuberculosis

Туберкулез и болезни лёгких, 2021
The review presents data from 55 publications about specific parameters of iron metabolism in the human body including those ill with tuberculosis. It describes processes aimed at isolating iron from pathogens and promoting the acquisition of iron by ...
R. Yu. Аbdullаev, O. G. Komissаrovа, O. R. Terentievа   +2 more
doaj   +1 more source

Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

Fluids and Barriers of the CNS, 2023
Here, we report an experimental setup to benchmark different receptors for targeted therapeutic antibody delivery at the blood–brain barrier. We used brain capillary endothelial-like cells derived from induced pluripotent stem cells (hiPSC-BECs) as a ...
Mikkel Roland Holst, Nienke Marije de Wit, Burak Ozgür, Andreas Brachner, Kathrine Hyldig, Antje Appelt-Menzel, Hannah Sleven, Zameel Cader, Helga Eveline de Vries, Winfried Neuhaus, Allan Jensen, Birger Brodin, Morten Schallburg Nielsen   +12 more
doaj   +1 more source

Quantum Dots Encapsulated with Canine Parvovirus-Like Particles Improving the Cellular Targeted Labeling. [PDF]

PLoS ONE, 2015
Quantum dots (QDs) have a promising prospect in live-cell imaging and sensing because of unique fluorescence features. QDs aroused significant interest in the bio-imaging field through integrating the fluorescence properties of QDs and the delivery ...
Dan Yan, Bin Wang, Shiqi Sun, Xia Feng, Ye Jin, Xueping Yao, Suizhong Cao, Huichen Guo   +7 more
doaj   +1 more source

Transferrin receptor-mediated internalization and intracellular fate of conjugates of a DNA aptamer

Molecular Therapy: Nucleic Acids, 2022
Aptamers have excellent specificity and affinity in targeting cell surface receptors, showing great potential in targeted delivery of drugs, siRNA, mRNA, and various nanomaterials with therapeutic function.
Nan Zhang, Junyan Wang, Tao Bing, Xiangjun Liu, Dihua Shangguan   +4 more
doaj   +1 more source

RELATIONSHIP OF CHANGES IN HEMATOLOGICAL AND BIOCHEMICAL INDICATORS OF PERIPHERAL BLOOD WITH THE TRANSFERRIN CONCENTRATION AND CD71+ LYMPHOCYTE COUNT

Siberian Journal of Life Sciences and Agriculture, 2022
Transferrin is an essential component of cell growth and metabolic processes that require iron. An increase in the expression of transferrin receptors on lymphocytes ensures their differentiation, maturation and activation of proliferation.
Veronika V. Patrakeeva, Liliya K. Dobrodeeva, Natal’ya P. Geshavec   +2 more
doaj   +1 more source

A method to selectively internalise submicrometer boron carbide particles into cancer cells using surface transferrin conjugation for developing a new boron neutron capture therapy agent

Journal of Experimental Nanoscience, 2020
With the goal of developing a new type of boron neutron capture therapy (BNCT) agent, selective internalisation of submicrometer boron carbide spherical particles into cancer cells via surface transferrin conjugation is demonstrated and confirmed in ...
Takuma Tsuji, Hiroshi Yoshitomi, Yoshie Ishikawa, Naoto Koshizaki, Motoshi Suzuki, Jiro Usukura   +5 more
doaj   +1 more source

Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation

Nature Communications, 2022
Autophagy can selectively target cargo for degradation. Here the authors map the proximal interactome of ATG8-paralogs LC3B and LC3C uncovering an LC3C-Endocytic-Associated-Pathway that selectively recruits internalized plasma membrane cargo, Met and ...
Paula P. Coelho, Geoffrey G. Hesketh, Annika Pedersen, Elena Kuzmin, Anne-Marie N. Fortier, Emily S. Bell, Colin D. H. Ratcliffe, Anne-Claude Gingras, Morag Park   +8 more
doaj   +1 more source