Results 21 to 30 of about 52,419 (262)

Heterotypic interactions between transferrin receptor and transferrin receptor 2 [PDF]

Blood, 2003
Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR). Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism.
Vogt, Todd M, Blackwell, Aaron D, Giannetti, Anthony M, Bjorkman, Pamela J, Enns, Caroline A   +4 more
openaire   +4 more sources

DISTRIBUTION OF TRANSFERRIN AND TRANSFERRIN RECEPTORS IN THE RABBIT PLACENTA [PDF]

Quarterly Journal of Experimental Physiology, 1983
The quantity and distribution of transferrin and transferrin‐binding sites in the placenta were investigated in rabbits on the 28th‐29th days of pregnancy. The animals were injected intravenously with a mixture of 59Fe‐125I‐labelled rabbit diferric transferrin and 131I‐labelled rabbit albumin.
E, Baker, F M, van Bockxmeer, E H, Morgan   +2 more
openaire   +2 more sources

Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation

Nature Communications, 2022
Autophagy can selectively target cargo for degradation. Here the authors map the proximal interactome of ATG8-paralogs LC3B and LC3C uncovering an LC3C-Endocytic-Associated-Pathway that selectively recruits internalized plasma membrane cargo, Met and ...
Paula P. Coelho, Geoffrey G. Hesketh, Annika Pedersen, Elena Kuzmin, Anne-Marie N. Fortier, Emily S. Bell, Colin D. H. Ratcliffe, Anne-Claude Gingras, Morag Park   +8 more
doaj   +1 more source

Magnetic and Fluorescent Dual-Labeled Genetically Encoded Targeted Nanoparticles for Malignant Glioma Cell Tracking and Drug Delivery

Pharmaceutics, 2023
Human glioblastoma multiforme (GBM) is a primary malignant brain tumor, a radically incurable disease characterized by rapid growth resistance to classical therapies, with a median patient survival of about 15 months.
Anna N. Gabashvili, Nelly S. Chmelyuk, Vera V. Oda, Maria K. Leonova, Viktoria A. Sarkisova, Polina A. Lazareva, Alevtina S. Semkina, Nikolai A. Belyakov, Timur R. Nizamov, Petr I. Nikitin   +9 more
doaj   +1 more source

Localization of Transferrin and Transferrin Receptors in Rat Testes [PDF]

Biology of Reproduction, 1984
One of the major proteins secreted by rat Sertoli cells in culture is a transferrin-like protein (Skinner and Griswold, 1980). The purpose of this study was to quantitate the amount of testicular transferrin in fluids isolated from the testis by the use of a radioimmunoassay and to determine the location of transferrin and transferrin receptors in the ...
S R, Sylvester, M D, Griswold
openaire   +2 more sources

UiO-66 metal-organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy. [PDF]

FEBS Open Bio
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Huntošová V, Rakhalskii G, Almáši M.
europepmc   +2 more sources

Structure of the Human Transferrin Receptor-Transferrin Complex [PDF]

Cell, 2004
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of
Cheng, Yifan, Zak, Olga, Aisen, Philip, Harrison, Stephen C, Walz, Thomas   +4 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Two peptides targeting endothelial receptors are internalized into murine brain endothelial cells.

PLoS ONE, 2021
The blood-brain barrier (BBB) is one of the main obstacles for therapies targeting brain diseases. Most macromolecules fail to pass the tight BBB, formed by brain endothelial cells interlinked by tight junctions.
Diána Hudecz, Sara Björk Sigurdardóttir, Sarah Christine Christensen, Casper Hempel, Andrew J Urquhart, Thomas Lars Andresen, Morten S Nielsen   +6 more
doaj   +1 more source

Two Interconvertible Folds Modulate the Activity of a DNA Aptamer Against Transferrin Receptor

Molecular Therapy: Nucleic Acids, 2014
Thanks to their ability to recognize biomolecular targets with high affinity and specificity, nucleic acid aptamers are increasingly investigated as diagnostic and therapeutic tools, particularly when their targets are cell-surface receptors.
David Porciani, Giovanni Signore, Laura Marchetti, Paolo Mereghetti, Riccardo Nifosì, Fabio Beltram   +5 more
doaj   +1 more source