Results 11 to 20 of about 50,081 (262)

Heterotypic interactions between transferrin receptor and transferrin receptor 2 [PDF]

Blood, 2003
Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR). Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism.
Vogt, Todd M, Blackwell, Aaron D, Giannetti, Anthony M, Bjorkman, Pamela J, Enns, Caroline A   +4 more
openaire   +4 more sources

Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation

Nature Communications, 2022
Autophagy can selectively target cargo for degradation. Here the authors map the proximal interactome of ATG8-paralogs LC3B and LC3C uncovering an LC3C-Endocytic-Associated-Pathway that selectively recruits internalized plasma membrane cargo, Met and ...
Paula P. Coelho, Geoffrey G. Hesketh, Annika Pedersen, Elena Kuzmin, Anne-Marie N. Fortier, Emily S. Bell, Colin D. H. Ratcliffe, Anne-Claude Gingras, Morag Park   +8 more
doaj   +1 more source

Localization of Transferrin and Transferrin Receptors in Rat Testes [PDF]

Biology of Reproduction, 1984
One of the major proteins secreted by rat Sertoli cells in culture is a transferrin-like protein (Skinner and Griswold, 1980). The purpose of this study was to quantitate the amount of testicular transferrin in fluids isolated from the testis by the use of a radioimmunoassay and to determine the location of transferrin and transferrin receptors in the ...
S R, Sylvester, M D, Griswold
openaire   +2 more sources

Magnetic and Fluorescent Dual-Labeled Genetically Encoded Targeted Nanoparticles for Malignant Glioma Cell Tracking and Drug Delivery

Pharmaceutics, 2023
Human glioblastoma multiforme (GBM) is a primary malignant brain tumor, a radically incurable disease characterized by rapid growth resistance to classical therapies, with a median patient survival of about 15 months.
Anna N. Gabashvili, Nelly S. Chmelyuk, Vera V. Oda, Maria K. Leonova, Viktoria A. Sarkisova, Polina A. Lazareva, Alevtina S. Semkina, Nikolai A. Belyakov, Timur R. Nizamov, Petr I. Nikitin   +9 more
doaj   +1 more source

DISTRIBUTION OF TRANSFERRIN AND TRANSFERRIN RECEPTORS IN THE RABBIT PLACENTA [PDF]

Quarterly Journal of Experimental Physiology, 1983
The quantity and distribution of transferrin and transferrin‐binding sites in the placenta were investigated in rabbits on the 28th‐29th days of pregnancy. The animals were injected intravenously with a mixture of 59Fe‐125I‐labelled rabbit diferric transferrin and 131I‐labelled rabbit albumin.
E, Baker, F M, van Bockxmeer, E H, Morgan   +2 more
openaire   +2 more sources

Structure of the Human Transferrin Receptor-Transferrin Complex [PDF]

Cell, 2004
Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). Although much is understood of the transferrin endocytotic cycle, little has been uncovered of the molecular details underlying the formation of
Cheng, Yifan, Zak, Olga, Aisen, Philip, Harrison, Stephen C, Walz, Thomas   +4 more
openaire   +2 more sources

Insights from targeting transferrin receptors to develop vaccines for pathogens of humans and food production animals

Frontiers in Cellular and Infection Microbiology, 2023
While developing vaccines targeting surface transferrin receptor proteins in Gram-negative pathogens of humans and food production animals, the common features derived from their evolutionary origins has provided us with insights on how improvements ...
Nikolas F. Ewasechko, Somshukla Chaudhuri, Anthony B. Schryvers, Anthony B. Schryvers   +3 more
doaj   +1 more source

Investigation into the Antigenic Properties and Contributions to Growth in Blood of the Meningococcal Haemoglobin Receptors, HpuAB and HmbR. [PDF]

PLoS ONE, 2015
Acquisition of iron from host complexes is mediated by four surface-located receptors of Neisseria meningitidis. The HmbR protein and heterodimeric HpuAB complex bind to haemoglobin whilst TbpBA and LbpBA bind iron-loaded transferrin and lactoferrin ...
Fadil A Bidmos, Hannah Chan, Uta Praekelt, Isfahan Tauseef, Youssif M Ali, Edward B Kaczmarski, Ian Feavers, Christopher D Bayliss   +7 more
doaj   +1 more source

Influence of the genetic makeup of common carp on the expression of iron-related genes during Trypanoplasma borreli infection

Journal of Veterinary Research, 2018
Genes related to iron metabolism play an important role in inflammatory response. The objective of this study was to investigate the role of ferritin, transferrin receptors 1a and 1b, and transferrin genes in the response to blood parasite infection in ...
Kamińska-Gibas Teresa, Irnazarow Ilgiz, Szczygieł Joanna, Jurecka Patrycja   +3 more
doaj   +1 more source

Factors associated with iron deficiency in heart failure

Кардиоваскулярная терапия и профилактика, 2023
Aim. To establish the factors associated with iron deficiency (ID) in pa- tients with heart failure (HF).Material and methods. We examined 294 patients with NYHA class II-IV HF as follows: 213 — with ID, 81 — without ID. All patients underwent a clinical
M. P. Smirnova, P. A. Chizhov
doaj   +1 more source