Results 31 to 40 of about 51,677 (239)
Receptor-mediated targeting of magnetic nanoparticles using insulin as a surface ligand to prevent endocytosis [PDF]
, 2003 Superparamagnetic iron oxide nanoparticles have been used for many years as magnetic resonance imaging contrast agents or in drug delivery applications.
Berry, C.C. +3 more
core +1 more source
Single-Molecule Imaging of Membrane Proteins on Vascular Endothelial Cells
Journal of Lipid and Atherosclerosis, 2023 Transporting substances such as gases, nutrients, waste, and cells is the primary function of blood vessels. Vascular cells use membrane proteins to perform crucial endothelial functions, including molecular transport, immune cell infiltration, and ...
Jiseong Park +3 more
doaj +1 more source
Two peptides targeting endothelial receptors are internalized into murine brain endothelial cells.
PLoS ONE, 2021 The blood-brain barrier (BBB) is one of the main obstacles for therapies targeting brain diseases. Most macromolecules fail to pass the tight BBB, formed by brain endothelial cells interlinked by tight junctions.
Diána Hudecz +6 more
doaj +1 more source
Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles
, 2004 The study reports the initial biological evaluation of targeted polymeric glycol chitosan vesicles as carrier systems for doxorubicin (Dox). Transferrin (Tf) was covalently bound to the Dox-loaded palmitoylated glycol chitosan (GCP) vesicles using ...
Dufès, Christine +5 more
core +1 more source
Neuropsychopharmacology Reports, 2021 Background Brain iron overload is linked to brain deterioration, and cognitive and motor impairment in neurodegenerative disorders and normal aging. Mutations in the HFE gene are associated with iron dyshomeostasis and are risk factors for peripheral ...
Grégoria Kalpouzos +4 more
doaj +1 more source
Two Interconvertible Folds Modulate the Activity of a DNA Aptamer Against Transferrin Receptor
Molecular Therapy: Nucleic Acids, 2014 Thanks to their ability to recognize biomolecular targets with high affinity and specificity, nucleic acid aptamers are increasingly investigated as diagnostic and therapeutic tools, particularly when their targets are cell-surface receptors.
David Porciani +5 more
doaj +1 more source
Transferrin receptors in rat plasma.
, 1988 peer reviewedAntigenic material in rat plasma reacting with rat transferrin receptor antibodies was identified as an intact receptor molecule complexed with transferrin. Plasma transferrin receptors were measured by ELISA in rats of different age and sex,
Beguin, Yves +3 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFE [PDF]
Journal of Biological Chemistry, 2000 The transferrin receptor (TfR) interacts with two proteins important for iron metabolism, transferrin (Tf) and HFE, the protein mutated in hereditary hemochromatosis. A second receptor for Tf, TfR2, was recently identified and found to be functional for iron uptake in transfected cells (Kawabata, H., Germain, R. S., Vuong, P. T., Nakamaki, T., Said, J.
West, Anthony P., Jr. +5 more
openaire +3 more sources
Endocytosis of the ASGP receptor H1 is reduced by mutation of tyrosine-5 but still occurs via coated pits [PDF]
, 1991 The clustering of plasma membrane receptors in clathrin-coated pits depends on determinants within their cytoplasmic domains. In several cases, individual tyrosine residues were shown to be necessary for rapid internalization.
Geffen, I +8 more
core +1 more source