Results 1 to 10 of about 25,679 (210)
Pharmaceuticals, 2018 Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to “hepcidinopathies„ ranging from hereditary hemochromatosis ...
Kostas Pantopoulos, Angeliki Katsarou
exaly +6 more sources
Identification of an iron–hepcidin complex [PDF]
Biochemical Journal, 2008 Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was later shown to be a key player in iron homoeostasis. It is now proposed to be the ‘iron hormone’ which, by interacting with the iron transporter ferroportin, prevents further iron import into the circulatory system.
Farnaud, Sébastien +5 more
core +13 more sources
Advances in Chronic Kidney Disease, 2019 Dysregulation of metabolism and utilization of iron can lead to the development and maintenance of anemia of CKD. Anemia is prevalent among patients with CKD. The markers of iron sufficiency or availability of iron are far from perfect which results in inaccurate diagnosis and treatment of anemia with poor outcomes.
Anil K, Agarwal, Jerry, Yee
core +4 more sources
Hepcidin in hepatocellular carcinoma [PDF]
British Journal of Cancer, 2022 AbstractHepatocellular carcinoma (HCC) is one of the most common reasons for cancer-related deaths. Excess iron increases HCC risk. Inevitably, hepcidin, the iron hormone that maintains systemic iron homoeostasis is involved in HCC pathology. Distinct from other cancers that show high hepcidin expression, HCC patients can show low hepcidin levels. Thus,
Jonathan H. Joachim, Kosha J. Mehta
openaire +4 more sources
Redox Biology, 2019 In mammals, the iron masterswitch hepcidin efficiently controls iron recycling by the macrophage-liver axis but the exact interplay between macrophages and hepatocytes remains poorly understood.
Sebastian Mueller +2 more
exaly +3 more sources
Hepcidin and Anemia: A Tight Relationship
Frontiers in Physiology, 2019 Hepcidin, the master regulator of systemic iron homeostasis, tightly influences erythrocyte production. High hepcidin levels block intestinal iron absorption and macrophage iron recycling, causing iron restricted erythropoiesis and anemia.
Antonella Nai +2 more
exaly +3 more sources
An Overlooked Hepcidin–Cadmium Connection [PDF]
International Journal of Molecular Sciences, 2022 Hepcidin (DTHFPICIFCCGCCHRSKCGMCCKT), an iron-regulatory hormone, is a 25-amino-acid peptide with four intramolecular disulfide bonds circulating in blood. Its hormonal activity is indirect and consists of marking ferroportin-1 (an iron exporter) for degradation.
Dawid Płonka +5 more
openaire +3 more sources
Transfusion Clinique et Biologique, 2023 The bioactive peptide hormone hepcidin-25 regulates iron levels by inhibiting iron transport to plasma via ferroportin. Hepcidin-25 is synthesized in the liver where the 84 amino acids pro-hepcidin is cleaved into the bioactive hepcidin-25. A patient admitted to the hospital presented with infertility and fatigue.Genomic DNA was purified from whole ...
Praeger-Jahnsen, Louis +5 more
openaire +4 more sources
Potential Usefulness of Urinary Hepcidin Measurement for Iron Deficiency Anemia in Female Athletes [PDF]
European Journal of Sport ScienceHepcidin is a key regulator of iron metabolism and has been proposed as a biomarker for detecting iron deficiency. This study examined serum hepcidin and non‐invasively measured urinary hepcidin in 260 female athletes to assess their potential utility in
Haruo Hanawa +8 more
doaj +2 more sources
Regulators of hepcidin expression
, 2019 Iron, an essential nutrient, is required for many biological processes but is also toxic in excess. The lack of a mechanism to excrete excess iron makes it crucial for the body to regulate the amount of iron absorbed from the diet. This regulation is mediated by the hepatic hormone hepcidin.
Roth, Marie-Paule +2 more
openaire +5 more sources