Results 1 to 10 of about 34,801 (229)
Cellular catabolism of the iron-regulatory peptide hormone hepcidin. [PDF]
PLoS ONE, 2013 Hepcidin, a 25-amino acid peptide hormone, is the principal regulator of plasma iron concentrations. Hepcidin binding to its receptor, the iron exporter ferroportin, induces ferroportin internalization and degradation, thus blocking iron efflux from ...
Gloria Cuevas Preza +3 more
doaj +8 more sources
Comparison of serum levels of hepcidin and pro-hepcidin in hemodialysis patients and healthy subjects [PDF]
Saudi Journal of Kidney Diseases and Transplantation, 2015 Hepcidin prevents absorption of iron from the intestine and inhibits release of iron from macrophages and hepatocytes. For this reason, it seems that high levels of hepcidin are a predisposing factor for anemia in chronic inflammatory conditions such as ...
N Taheri +6 more
doaj +3 more sources
Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent. [PDF]
PLoS ONE, 2012 Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages.
Xinggang Wu +6 more
doaj +5 more sources
Hepcidin and Host Defense against Infectious Diseases. [PDF]
PLoS Pathogens, 2015 Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.
Kathryn Michels +3 more
doaj +2 more sources
Hepcidin and Anemia: A Tight Relationship
Frontiers in Physiology, 2019 Hepcidin, the master regulator of systemic iron homeostasis, tightly influences erythrocyte production. High hepcidin levels block intestinal iron absorption and macrophage iron recycling, causing iron restricted erythropoiesis and anemia.
Alessia Pagani +2 more
exaly +3 more sources
Low Serum Hepcidin in Patients with Autoimmune Liver Diseases. [PDF]
PLoS ONE, 2015 Hepcidin, a liver hormone, is important for both innate immunity and iron metabolism regulation. As dysfunction of the hepcidin pathway may contribute to liver pathology, we analysed liver hepcidin mRNA and serum hepcidin in patients with chronic liver ...
Aggeliki Lyberopoulou +12 more
doaj +1 more source
Frontiers in Immunology, 2021 Lung cancer has the highest death rate among cancers globally. Hepcidin is a fascinating regulator of iron metabolism; however, the prognostic value of hepcidin and its correlation with immune cell infiltration in lung cancer remain unclear.
Yumei Fan +9 more
doaj +1 more source
eLife, 2022 The iron hormone hepcidin is transcriptionally activated by iron or inflammation via distinct, partially overlapping pathways. We addressed how iron affects inflammatory hepcidin levels and the ensuing hypoferremic response. Dietary iron overload did not
Edouard Charlebois +8 more
doaj +1 more source
Redox Biology, 2019 In mammals, the iron masterswitch hepcidin efficiently controls iron recycling by the macrophage-liver axis but the exact interplay between macrophages and hepatocytes remains poorly understood.
Inês Silva +3 more
doaj +1 more source
Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya. [PDF]
PLoS ONE, 2013 Hepcidin regulation by competing stimuli such as infection and iron deficiency has not been studied in infants and it's yet unknown whether hepcidin regulatory pathways are fully functional in infants.
Tanja Jaeggi +8 more
doaj +1 more source