Anemia of Inflammation in Solid Tumor Patients and Practical Education for Oncologists and Nurses. [PDF]
Thorac CancerTumor‐ and immune‐derived cytokines including IL‐6, IL‐1β, TNF‐α, TGF‐β, IL‐10, and IFN‐γ drive anemia of inflammation: IL‐6/TNF‐α upregulate hepatic hepcidin to block iron export, while other cytokines suppress erythropoiesis and shorten red cell survival.
Si X +5 more
europepmc +2 more sources
Correction to 'Clinical Trial: Predicting Response to Iron Therapy in Patients With Active Inflammatory Bowel Disease Using Hepcidin and Functional Iron Indices: A Multicentre Randomised Trial'. [PDF]
Aliment Pharmacol Thereuropepmc +3 more sources
Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders [PDF]
The Scientific World JOURNAL, 2011 Iron is essential for human life, but toxic if present in excess. To avoid iron overload and maintain iron homeostasis, all cells are able to regulate their iron content through the post-transcriptional control of iron genes operated by the cytosolic iron regulatory proteins that interact with iron responsive elements on iron gene mRNA. At the systemic
CAMASCHELLA , CLARA, SILVESTRI L.
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eLife, 2022 The iron hormone hepcidin is transcriptionally activated by iron or inflammation via distinct, partially overlapping pathways. We addressed how iron affects inflammatory hepcidin levels and the ensuing hypoferremic response. Dietary iron overload did not
Edouard Charlebois +8 more
doaj +1 more source
Frontiers in Immunology, 2021 Lung cancer has the highest death rate among cancers globally. Hepcidin is a fascinating regulator of iron metabolism; however, the prognostic value of hepcidin and its correlation with immune cell infiltration in lung cancer remain unclear.
Yumei Fan +9 more
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Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury
Frontiers in Pharmacology, 2019 Background: Acute kidney injury (AKI) portends worse prognosis following sepsis, with limited available interventions. Host iron acquisition by pathogens and systemic inflammatory response are key events in the pathogenesis of sepsis. In sepsis, hepcidin
Yogesh Scindia +7 more
doaj +1 more source
Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya. [PDF]
PLoS ONE, 2013 Hepcidin regulation by competing stimuli such as infection and iron deficiency has not been studied in infants and it's yet unknown whether hepcidin regulatory pathways are fully functional in infants.
Tanja Jaeggi +8 more
doaj +1 more source
Hepcidin Induces M1 Macrophage Polarization in Monocytes or THP-1 Derived Macrophages [PDF]
Iranian Journal of Immunology, 2019 Background: Macrophage polarization plays a critical role in determining the inflammatory states. Hepcidin is a key negative regulator of iron homeostasis and functions.
Enna Liu +3 more
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A tincture of hepcidin cures all: the potential for hepcidin therapeutics [PDF]
Journal of Clinical Investigation, 2010 Iron overload as a result of blood transfusions and excessive intestinal iron absorption can be a complication of chronic anemias such as β-thalassemia. Inappropriately low levels of hepcidin, a negative regulator of iron absorption and recycling, underlie the pathophysiology of the intestinal hyperabsorption. In this issue of the JCI, Gardenghi et al.
Thomas B, Bartnikas, Mark D, Fleming
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JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013 Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red cells in macrophages and from storage in hepatocytes.
Subha Palaneeswari M. +4 more
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