Results 21 to 30 of about 25,679 (210)
Hepcidin antagonists for potential treatments of disorders with hepcidin excess [PDF]
Frontiers in Pharmacology, 2014 The discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by furin into the mature active peptide. Hepcidin binds ferroportin, the only cellular iron exporter, causing the internalization and degradation of both.
POLI, Maura +4 more
openaire +3 more sources
Hepcidin Induces M1 Macrophage Polarization in Monocytes or THP-1 Derived Macrophages [PDF]
Iranian Journal of Immunology, 2019 Background: Macrophage polarization plays a critical role in determining the inflammatory states. Hepcidin is a key negative regulator of iron homeostasis and functions.
Enna Liu +3 more
doaj +1 more source
Understanding and exploiting hepcidin as an indicator of anemia due to chronic kidney disease
Kidney Research and Clinical Practice, 2013 Hepcidin, produced by the liver, is the master regulator of iron balance. Serum hepcidin is increased by high iron stores, blocks intestinal iron absorption, and impairs storage iron release.
Derek S. Larson, Daniel W. Coyne
doaj +1 more source
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013 Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red cells in macrophages and from storage in hepatocytes.
Subha Palaneeswari M. +4 more
openaire +3 more sources
Benefits and risks of iron supplementation in anemic neonatal pigs. [PDF]
, 2010 Iron deficiency is a common health problem. The most severe consequence of this disorder is iron deficiency anemia (IDA), which is considered the most common nutritional deficiency worldwide. Newborn piglets are an ideal model to explore the multifaceted
Thibaudeau, Olivier +12 more
core +2 more sources
Advances in Hematology, 2011 Hepcidin is upregulated by inflammation and iron. Inherited (HFE genotype) and treatment-related factors (blood units (BU), Iron overload) affecting hepcidin (measured by C-ELISA) were studied in 42 consecutive patients with AML prior to and after ...
Ann-Kathrin Eisfeld +8 more
doaj +1 more source
Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria
Haematologica, 2012 Hepcidin levels are high and iron absorption is limited in acute malaria. The mechanism(s) that regulate hepcidin secretion remain undefined. We have measured hepcidin concentration and cytokines in 100 Kenyan children with acute falciparum malaria and ...
Climent Casals-Pascual +6 more
doaj +1 more source
, 2022 The hepcidin is antimicrobial peptide has antimicrobial effects discover before more than a thousand years; it has a great role in iron metabolism and innate immunity. Hepcidin is a regulator of iron homeostasis. Its production is increased by iron excess and inflammation and decreased by hypoxia and anemia.
Safa A. Faraj, Naeem M. Al-Abedy
openaire +1 more source
Hepcidin expression in iron overload diseases is variably modulated by circulating factors. [PDF]
PLoS ONE, 2012 Hepcidin is a regulatory hormone that plays a major role in controlling body iron homeostasis. Circulating factors (holotransferrin, cytokines, erythroid regulators) might variably contribute to hepcidin modulation in different pathological conditions ...
Giulia Ravasi +11 more
doaj +1 more source
SRM-MS Method Development for Hepcidin-25 Peptide
Journal of Analytical Methods in Chemistry, 2018 As advanced mass spectrometry- (MS-) based hepcidin analysis offers to overcome the limitations in analytical methods using antihepcidin, further improvement of MS detection sensitivity for the peptide may enhance the diagnostic value of the hepcidin for
Kyung-Cho Cho +5 more
doaj +1 more source