Results 21 to 30 of about 34,801 (229)
Identification of erythroferrone as an erythroid regulator of iron metabolism. [PDF]
, 2014 Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores.
Ganz, Tomas +5 more
core +1 more source
Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins [PDF]
Biomedicines, 2021 The peptide hormone hepcidin is one of the key regulators of iron absorption, plasma iron levels, and tissue iron distribution. Hepcidin functions by binding to and inducing the internalisation and subsequent lysosomal degradation of ferroportin, which reduces both iron absorption in the gut and export of iron from storage to ultimately decrease ...
Daniela Goncalves Monteiro +7 more
openaire +5 more sources
Hepcidin Induces M1 Macrophage Polarization in Monocytes or THP-1 Derived Macrophages [PDF]
Iranian Journal of Immunology, 2019 Background: Macrophage polarization plays a critical role in determining the inflammatory states. Hepcidin is a key negative regulator of iron homeostasis and functions.
Enna Liu +3 more
doaj +1 more source
Hepcidin and sports anemia [PDF]
Cell & Bioscience, 2014 Iron is an important mineral element used by the body in a variety of metabolic and physiologic processes. These processes are highly active when the body is undergoing physical exercises. Prevalence of exercise-induced iron deficiency anemia (also known as sports anemia) is notably high in athletic populations, particularly those with heavy training ...
Kong, Wei-Na +2 more
openaire +2 more sources
Understanding and exploiting hepcidin as an indicator of anemia due to chronic kidney disease
Kidney Research and Clinical Practice, 2013 Hepcidin, produced by the liver, is the master regulator of iron balance. Serum hepcidin is increased by high iron stores, blocks intestinal iron absorption, and impairs storage iron release.
Derek S. Larson, Daniel W. Coyne
doaj +1 more source
Advances in Hematology, 2011 Hepcidin is upregulated by inflammation and iron. Inherited (HFE genotype) and treatment-related factors (blood units (BU), Iron overload) affecting hepcidin (measured by C-ELISA) were studied in 42 consecutive patients with AML prior to and after ...
Ann-Kathrin Eisfeld +8 more
doaj +1 more source
Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria
Haematologica, 2012 Hepcidin levels are high and iron absorption is limited in acute malaria. The mechanism(s) that regulate hepcidin secretion remain undefined. We have measured hepcidin concentration and cytokines in 100 Kenyan children with acute falciparum malaria and ...
Climent Casals-Pascual +6 more
doaj +1 more source
Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: an interventional study [PDF]
, 2018 The discovery of the ferroportin-hepcidin complex has led to a critical review on the treatment of anemia and anemia of inflammation (AI). Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively regulated by hepcidin, a ...
Antimo Cutone +6 more
core +2 more sources
Ironing out the details: Untangling dietary iron and genetic background in diabetes [PDF]
, 2018 The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health.
Lawson, Heather A, Miranda, Mario A
core +2 more sources
SRM-MS Method Development for Hepcidin-25 Peptide
Journal of Analytical Methods in Chemistry, 2018 As advanced mass spectrometry- (MS-) based hepcidin analysis offers to overcome the limitations in analytical methods using antihepcidin, further improvement of MS detection sensitivity for the peptide may enhance the diagnostic value of the hepcidin for
Kyung-Cho Cho +5 more
doaj +1 more source