Results 1 to 10 of about 1,910,895 (254)
Rhabdomyolysis after Intravenous Ferric Gluconate: A Case Report
European Journal of Case Reports in Internal Medicine, 2022 Patients with severe iron deficiency, malabsorption or intolerance to oral iron are frequently treated with intravenous iron replacement. We report the case of a 42-year-old woman with non-erosive oligoarticular arthritis with antiparietal cell ...
Mara Botti +3 more
doaj +1 more source
The emerging role of furin in neurodegenerative and neuropsychiatric diseases
Translational Neurodegeneration, 2022 Furin is an important mammalian proprotein convertase that catalyzes the proteolytic maturation of a variety of prohormones and proproteins in the secretory pathway.
Yi Zhang +5 more
doaj +1 more source
Iron metabolism and iron disorders revisited in the hepcidin era
Haematologica, 2020 Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell and systemic levels to prevent both deficiency and overload.
Clara Camaschella +2 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 PKAN disease is caused by mutations in the PANK2 gene, encoding the mitochondrial enzyme pantothenate kinase 2, catalyzing the first and key reaction in Coenzyme A (CoA) biosynthetic process.
Maddalena Ripamonti +8 more
doaj +1 more source
COBALAMIN DEFICIENCY IN THE ELDERLY
Mediterranean Journal of Hematology and Infectious Diseases, 2020 Older people are at risk for cobalamin (vitamin B12) deficiency because of a number of common disorders (e.g. autoimmune gastritis) and drugs (e.g. antacids) that may alter its absorption and utilization.
Giacomo Marchi +4 more
doaj +1 more source
Redox Biology, 2022 Oxidative stress and deficient bioenergetics are key players in the pathological process of cerebral ischemia reperfusion injury (I/R). As a mitochondrial iron storage protein, mitochondrial ferritin (FtMt) plays a pivotal role in protecting neuronal ...
Peina Wang +6 more
doaj +1 more source
Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis
Haematologica, 2018 The stimulation of erythrocyte formation increases the demand for iron by the bone marrow and this in turn may affect the levels of circulating diferric transferrin.
Cornel S.G. Mirciov +5 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2017 Background & Aims: Previous studies have suggested that iron absorption in suckling mammals is refractory to stimuli that normally would decrease absorption in adults.
David M. Frazer +5 more
doaj +1 more source
Cell Death and Disease, 2022 Brain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The regulation of iron traffic at the blood-brain barrier (BBB) is crucial to maintain brain iron homeostasis.
Linhao You +10 more
doaj +1 more source
Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis
Cell Death and Disease, 2021 Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated.
Peina Wang +9 more
doaj +1 more source