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Iron Metabolism in Aging and Age-Related Diseases [PDF]
International Journal of Molecular Sciences, 2022 Iron is a trace metal element necessary to maintain life and is also involved in a variety of biological processes. Aging refers to the natural life process in which the physiological functions of the various systems, organs, and tissues decline ...
Yuanliangzi Tian +2 more
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International Journal of Molecular Sciences, 2022 Iron homeostasis disruption has increasingly been implicated in various neurological disorders. In this review, we present an overview of our current understanding of iron metabolism in the central nervous system. We examine the consequences of both iron
Christina A Porras +2 more
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Macrophages and Iron Metabolism [PDF]
Immunity, 2016 Iron is a transition metal that due to its inherent ability to exchange electrons with a variety of molecules is essential to support life. In mammals, iron exists mostly in the form of heme, enclosed within an organic protoporphyrin ring and functioning primarily as a prosthetic group in proteins.
Miguel P. Soares, Iqbal Hamza
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Physiology and Pathophysiology of Iron Metabolism
, 2023 This reprint focuses on the importance of the micronutrient iron in human physiological iron homeostasis and iron-related diseases. Daily adequate dietary iron supply ensures vital body functions and hemoglobin synthesis during erythropoiesis. During the
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Iron metabolism in trypanosomatids, and its crucial role in infection. [PDF]
, 2010 Iron is almost ubiquitous in living organisms due to the utility of its redox chemistry. It is also dangerous as it can catalyse the formation of reactive free radicals - a classical double-edged sword.
Taylor, MC, Kelly, JM
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Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]
, 2002 As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem +11 more
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Physiology of Iron Metabolism [PDF]
Transfusion Medicine and Hemotherapy, 2014 A revolution occurred during the last decade in the comprehension of the physiology as well as in the physiopathology of iron metabolism. The purpose of this review is to summarize the recent knowledge that has accumulated, allowing a better comprehension of the mechanisms implicated in iron homeostasis. Iron metabolism is very fine tuned.
Sophie, Waldvogel-Abramowski +6 more
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Safety Aspects of Iron in Food [PDF]
, 2001 During the last decades efforts regarding dietary iron supply focused mostly on the prevention of deficiencies, especially during growth and pregnancy.
Schümann, Klaus
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Iron Metabolism in Ferroptosis [PDF]
Frontiers in Cell and Developmental Biology, 2020 Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the production of reactive oxygen species and enzyme activity in lipid peroxidation, ferroptosis is strictly ...
Xin Chen +5 more
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The Role of Fractalkine in the Regulation of Endometrial Iron Metabolism in Iron Deficiency
, 2023 Iron is a crucial element in the human body. Endometrial iron metabolism is implicated in endometrium receptivity and embryo implantation. Disturbances of the maternal as well as the endometrial iron homeostasis, such as iron deficiency, can contribute ...
Edina Pandur +4 more
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