Results 31 to 40 of about 2,003,726 (300)

Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis

Cell Death and Disease, 2021
Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated.
Peina Wang, Yanmei Cui, Qianqian Ren, Bingqi Yan, Yashuo Zhao, Peng Yu, Guofen Gao, Honglian Shi, Shiyang Chang, Yan-Zhong Chang   +9 more
doaj   +1 more source

Overexpression of Mitochondrial Ferritin Enhances Blood–Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells

Antioxidants, 2022
Blood–brain barrier (BBB) breakdown, a characteristic feature of ischemic stroke, contributes to poor patient outcomes. Brain microvascular endothelial cells (BMVECs) are a key component of the BBB and dysfunction or death of these cells following ...
Peina Wang, Qianqian Ren, Mengtong Shi, Yuanyuan Liu, Huiyuan Bai, Yan-Zhong Chang   +5 more
doaj   +1 more source

Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]

, 2002
As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem, Priem, F, Kaufmann, Stefan HE, Collins, Helen L, Ulrich E. Schaible, Kaufmann, S H E, Schaible, Ulrich E, Helen L. Collins, Collins, H L, Priem, Friedrich, Stefan H.E. Kaufmann, Schaible, U E   +11 more
core   +1 more source

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

Neurobiology of Disease, 2015
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that ...
Manik C. Ghosh, De-Liang Zhang, Tracey A. Rouault   +2 more
doaj   +1 more source

Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and CeruloplasminSummary

Cellular and Molecular Gastroenterology and Hepatology, 2018
Background & Aims: Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe2+ from the iron exporter ferroportin 1 for delivery to the circulating Fe3 ...
Brie K. Fuqua, Yan Lu, David M. Frazer, Deepak Darshan, Sarah J. Wilkins, Linda Dunn, Alex V. Loguinov, Scott C. Kogan, Pavle Matak, Huijun Chen, Joshua L. Dunaief, Chris D. Vulpe, Gregory J. Anderson   +12 more
doaj   +1 more source

A Novel ALAS2 Missense Mutation in Two Brothers With Iron Overload and Associated Alterations in Serum Hepcidin/Erythroferrone Levels

Frontiers in Physiology, 2020
Iron loading anemias are characterized by ineffective erythropoiesis and iron overload. The prototype is non-transfusion dependent ß-thalassemia (NTDT), with other entities including congenital sideroblastic anemias, congenital dyserythropoietic anemias,
Acaynne Lira Zidanes, Acaynne Lira Zidanes, Giacomo Marchi, Giacomo Marchi, Fabiana Busti, Fabiana Busti, Alessandro Marchetto, Elisa Fermo, Alejandro Giorgetti, Alice Vianello, Alice Vianello, Annalisa Castagna, Annalisa Castagna, Oliviero Olivieri, Oliviero Olivieri, Paola Bianchi, Domenico Girelli, Domenico Girelli   +17 more
doaj   +1 more source

Alterations of iron metabolism during heart ischemia/reperrfusion injury. Cytoprotective effects of Simvastatin. [PDF]

, 2011
Ischemic heart disease, the main cause of mortality and morbidity in industrialized countries, is a metabolic phenomenon due to an inadequate oxygenation of heart tissue caused by the closing or narrowing of the coronary arteries.
Di Pascale, Antonio
core   +1 more source

Iron metabolism in human body and its regulatory factors [PDF]

Jichu yixue yu linchuang, 2022
This article reviews the molecular mechanism of iron metabolism covering iron absorption,transportation,utilization and storage with focus on the key proteins involved in iron metabolism and elaborate regulation factors.
CHEN Chun-mei, GE Pin, GUO Chong
doaj   +1 more source

Iron Metabolism in Ferroptosis [PDF]

Frontiers in Cell and Developmental Biology, 2020
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent oxidative damage and subsequent plasma membrane ruptures and the release of damage-associated molecular patterns. Due to the role of iron in mediating the production of reactive oxygen species and enzyme activity in lipid peroxidation, ferroptosis is strictly ...
Xin Chen, Xin Chen, Chunhua Yu, Rui Kang, Daolin Tang, Daolin Tang   +5 more
openaire   +3 more sources

Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories. [PDF]

, 2016
Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Arber, C, Houlden, H, H. Houlden, C. E. Arber, S. Wray, Wray, S, A. Li, Li, A   +7 more
core   +1 more source