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Iron Metabolism in Cancer [PDF]
International Journal of Molecular Sciences, 2018 Demanded as an essential trace element that supports cell growth and basic functions, iron can be harmful and cancerogenic though. By exchanging between its different oxidized forms, iron overload induces free radical formation, lipid peroxidation, DNA, and protein damages, leading to carcinogenesis or ferroptosis.
Yafang Wang, Lei Yu, Jian Ding, Yi Chen
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COBALAMIN DEFICIENCY IN THE ELDERLY
Mediterranean Journal of Hematology and Infectious Diseases, 2020 Older people are at risk for cobalamin (vitamin B12) deficiency because of a number of common disorders (e.g. autoimmune gastritis) and drugs (e.g. antacids) that may alter its absorption and utilization.
Giacomo Marchi +4 more
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Molecular effects of alcohol on iron metabolism
, 2015 This chapter explores the link between iron and alcohol metabolism. Chronic alcohol consumption alters the expression of numerous iron-related proteins including the liver-secreted systemic iron-regulator hepcidin.
Mehta, K., Patel, V.B., Farnaud, S.
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Iron metabolism in trypanosomatids, and its crucial role in infection. [PDF]
, 2010 Iron is almost ubiquitous in living organisms due to the utility of its redox chemistry. It is also dangerous as it can catalyse the formation of reactive free radicals - a classical double-edged sword.
Taylor, MC, Kelly, JM
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Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis
Haematologica, 2018 The stimulation of erythrocyte formation increases the demand for iron by the bone marrow and this in turn may affect the levels of circulating diferric transferrin.
Cornel S.G. Mirciov +5 more
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Cellular and Molecular Gastroenterology and Hepatology, 2017 Background & Aims: Previous studies have suggested that iron absorption in suckling mammals is refractory to stimuli that normally would decrease absorption in adults.
David M. Frazer +5 more
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The Role of Fractalkine in the Regulation of Endometrial Iron Metabolism in Iron Deficiency
, 2023 Iron is a crucial element in the human body. Endometrial iron metabolism is implicated in endometrium receptivity and embryo implantation. Disturbances of the maternal as well as the endometrial iron homeostasis, such as iron deficiency, can contribute ...
Edina Pandur +4 more
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Macrophages and Iron Metabolism [PDF]
Immunity, 2016 Iron is a transition metal that due to its inherent ability to exchange electrons with a variety of molecules is essential to support life. In mammals, iron exists mostly in the form of heme, enclosed within an organic protoporphyrin ring and functioning primarily as a prosthetic group in proteins.
Miguel P. Soares, Iqbal Hamza
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Cell Death and Disease, 2022 Brain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The regulation of iron traffic at the blood-brain barrier (BBB) is crucial to maintain brain iron homeostasis.
Linhao You +10 more
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New Advances in Iron Metabolism, Ferritin and Hepcidin Research
, 2022 The interest in the regulation of iron metabolism has increased in recent years with the clarification of the mechanism by which hepcidin regulates systemic iron homeostasis and the discovery of ferritinophagy, the major mechanism of ferritin degradation,
Paolo Arosio, Arosio, Paolo
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