Results 21 to 30 of about 484,048 (304)

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

Neurobiology of Disease, 2015
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that ...
Manik C. Ghosh, De-Liang Zhang, Tracey A. Rouault   +2 more
doaj   +1 more source

Iron metabolism of in­testinal mucosa in various blood diseases [PDF]

, 1964
For the investigation of iron metabolism in the intestinal mucosa in various　blood diseases, intestinal biopsy (duodenum) was performed on 10 healthy controls　and 35 cases with various blood diseases.
Kimura, Ikuro, Kodani, Hidenari, Tsuchida, Junichiro   +2 more
core   +1 more source

Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and CeruloplasminSummary

Cellular and Molecular Gastroenterology and Hepatology, 2018
Background & Aims: Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe2+ from the iron exporter ferroportin 1 for delivery to the circulating Fe3 ...
Brie K. Fuqua, Yan Lu, David M. Frazer, Deepak Darshan, Sarah J. Wilkins, Linda Dunn, Alex V. Loguinov, Scott C. Kogan, Pavle Matak, Huijun Chen, Joshua L. Dunaief, Chris D. Vulpe, Gregory J. Anderson   +12 more
doaj   +1 more source

Iron Deficiency in Infancy and Its Impact on Motor and Mental Development [PDF]

, 2020
Iron plays a large role in nerve myelination, dopamine neurotransmission, and neuronal metabolism. The purpose of this literary review was to investigate the connection between iron deficiency and motor and cognitive development.
Baker, Emma
core   +1 more source

Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis [PDF]

, 2018
Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood.
Camacho, António, Cancela, M. Leonor, Cohen-Solal, Martine, Hang Korng, Ea, Ostertag, Agnès, Pinto, I. Jorge, Porto, Graça, Simão, Márcio   +7 more
core   +4 more sources

A Novel ALAS2 Missense Mutation in Two Brothers With Iron Overload and Associated Alterations in Serum Hepcidin/Erythroferrone Levels

Frontiers in Physiology, 2020
Iron loading anemias are characterized by ineffective erythropoiesis and iron overload. The prototype is non-transfusion dependent ß-thalassemia (NTDT), with other entities including congenital sideroblastic anemias, congenital dyserythropoietic anemias,
Acaynne Lira Zidanes, Acaynne Lira Zidanes, Giacomo Marchi, Giacomo Marchi, Fabiana Busti, Fabiana Busti, Alessandro Marchetto, Elisa Fermo, Alejandro Giorgetti, Alice Vianello, Alice Vianello, Annalisa Castagna, Annalisa Castagna, Oliviero Olivieri, Oliviero Olivieri, Paola Bianchi, Domenico Girelli, Domenico Girelli   +17 more
doaj   +1 more source

Iron metabolism in human body and its regulatory factors [PDF]

Jichu yixue yu linchuang, 2022
This article reviews the molecular mechanism of iron metabolism covering iron absorption,transportation,utilization and storage with focus on the key proteins involved in iron metabolism and elaborate regulation factors.
CHEN Chun-mei, GE Pin, GUO Chong
doaj   +1 more source

UV-light-driven prebiotic synthesis of iron–sulfur clusters [PDF]

, 2017
Iron–sulfur clusters are ancient cofactors that play a fundamental role in metabolism and may have impacted the prebiotic chemistry that led to life.
Bonfio, Claudia, Evans, David J., Jin, Lin, Mansy, Sheref, Mansy, Sheref S., Sasselov, Dimitar, Sasselov, Dimitar D., Scintilla, Simone, Shah, Sachin, Sutherland, John, Sutherland, John D., Szostak, Jack, Szostak, Jack W., Valer, Luca   +13 more
core   +1 more source

Heme metabolism genes Downregulated in COPD Cachexia. [PDF]

, 2020
IntroductionCachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes.
Agusti, Alvar, Arora, Itika, Bhatt, Surya P, Casaburi, Richard, Castaldi, Peter J, Dransfield, Mark T, Hersh, Craig P, Kumar, Preeti L, Lee, Sool, Lomas, David A, McDonald, Merry-Lynn N, Morrow, Jarrett D, Parker, Margaret M, Rennard, Stephen I, Silverman, Edwin K, Tal-Singer, Ruth, Thannickal, Victor J, Tiwari, Hemant K, Washko, George, Wells, J Michael, Wilson, Ava C, Wouters, Emiel FM   +21 more
core   +3 more sources

Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke

Cell Death and Disease, 2023
Ischemic stroke is associated with high mortality and morbidity rates worldwide. However, the molecular mechanisms underlying the neuronal damage incurred by stroke victims remain unclear.
Huiwen Zheng, Xin Guo, Shaomeng Kang, Zhongda Li, Tian Tian, Jianhua Li, Fudi Wang, Peng Yu, Shiyang Chang, Yan-zhong Chang   +9 more
doaj   +1 more source