Results 11 to 20 of about 1,910,895 (254)

Identification of an iron–hepcidin complex [PDF]

, 2008
Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was later shown to be a key player in iron homoeostasis. It is now proposed to be the 'iron hormone' which, by interacting with the iron transporter ferroportin,
Bui, T.T.T., Bui, Tam T.T., Rapisarda, C., Evans, R.W., Bui, T, Cammack, R, Drake, AF, Cammack, Richard, Rapisarda, C, Cammack, R., Drake, A, Evans, R W, Farnaud, SJ, Bui, TT, Evans, Robert W, Farnaud, Sebastien, Farnaud, S., Drake, Alex F., Evans, RW, Rapisarda, Chiara, Bui, Tam, Farnaud, Sébastien Jean-Claude, Drake, A.F., Farnaud, S   +23 more
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Molecular effects of alcohol on iron metabolism

, 2015
This chapter explores the link between iron and alcohol metabolism. Chronic alcohol consumption alters the expression of numerous iron-related proteins including the liver-secreted systemic iron-regulator hepcidin.
Mehta, K., Patel, V.B., Farnaud, S.
core   +5 more sources

Physiology and Pathophysiology of Iron Metabolism

, 2023
This reprint focuses on the importance of the micronutrient iron in human physiological iron homeostasis and iron-related diseases. Daily adequate dietary iron supply ensures vital body functions and hemoglobin synthesis during erythropoiesis. During the

core   +1 more source

Iron metabolism in trypanosomatids, and its crucial role in infection. [PDF]

, 2010
Iron is almost ubiquitous in living organisms due to the utility of its redox chemistry. It is also dangerous as it can catalyse the formation of reactive free radicals - a classical double-edged sword.
Taylor, MC, Kelly, JM
core   +1 more source

Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]

, 2002
As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem, Priem, F, Kaufmann, Stefan HE, Collins, Helen L, Ulrich E. Schaible, Kaufmann, S H E, Schaible, Ulrich E, Helen L. Collins, Collins, H L, Priem, Friedrich, Stefan H.E. Kaufmann, Schaible, U E   +11 more
core   +1 more source

Overexpression of Mitochondrial Ferritin Enhances Blood–Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells

Antioxidants, 2022
Blood–brain barrier (BBB) breakdown, a characteristic feature of ischemic stroke, contributes to poor patient outcomes. Brain microvascular endothelial cells (BMVECs) are a key component of the BBB and dysfunction or death of these cells following ...
Peina Wang, Qianqian Ren, Mengtong Shi, Yuanyuan Liu, Huiyuan Bai, Yan-Zhong Chang   +5 more
doaj   +1 more source

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

Neurobiology of Disease, 2015
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by binding to RNA stem loops known as iron responsive elements (IREs) that are found in the untranslated regions of target mRNAs that ...
Manik C. Ghosh, De-Liang Zhang, Tracey A. Rouault   +2 more
doaj   +1 more source

Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and CeruloplasminSummary

Cellular and Molecular Gastroenterology and Hepatology, 2018
Background & Aims: Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe2+ from the iron exporter ferroportin 1 for delivery to the circulating Fe3 ...
Brie K. Fuqua, Yan Lu, David M. Frazer, Deepak Darshan, Sarah J. Wilkins, Linda Dunn, Alex V. Loguinov, Scott C. Kogan, Pavle Matak, Huijun Chen, Joshua L. Dunaief, Chris D. Vulpe, Gregory J. Anderson   +12 more
doaj   +1 more source

A Novel ALAS2 Missense Mutation in Two Brothers With Iron Overload and Associated Alterations in Serum Hepcidin/Erythroferrone Levels

Frontiers in Physiology, 2020
Iron loading anemias are characterized by ineffective erythropoiesis and iron overload. The prototype is non-transfusion dependent ß-thalassemia (NTDT), with other entities including congenital sideroblastic anemias, congenital dyserythropoietic anemias,
Acaynne Lira Zidanes, Acaynne Lira Zidanes, Giacomo Marchi, Giacomo Marchi, Fabiana Busti, Fabiana Busti, Alessandro Marchetto, Elisa Fermo, Alejandro Giorgetti, Alice Vianello, Alice Vianello, Annalisa Castagna, Annalisa Castagna, Oliviero Olivieri, Oliviero Olivieri, Paola Bianchi, Domenico Girelli, Domenico Girelli   +17 more
doaj   +1 more source

Iron metabolism in human body and its regulatory factors [PDF]

Jichu yixue yu linchuang, 2022
This article reviews the molecular mechanism of iron metabolism covering iron absorption,transportation,utilization and storage with focus on the key proteins involved in iron metabolism and elaborate regulation factors.
CHEN Chun-mei, GE Pin, GUO Chong
doaj   +1 more source