The ins and outs of metal homeostasis by the root nodule actinobacterium Frankia [PDF]
, 2014 Background: Frankia are actinobacteria that form a symbiotic nitrogen-fixing association with actinorhizal plants, and play a significant role in actinorhizal plant colonization of metal contaminated areas.
Furnholm, Teal R., Tisa, Louis S.
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Systemic iron homeostasis and erythropoiesis [PDF]
IUBMB Life, 2017 AbstractIron is an essential nutrient that is potentially toxic due to its redox reactivity. Insufficient iron supply to erythroid cells, the major iron consumers in the body, leads to various forms of anemia. On the other hand, iron overload (hemochromatosis) is associated with tissue damage and diseases of liver, pancreas, and heart.
George, Papanikolaou +1 more
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Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: an interventional study [PDF]
, 2018 The discovery of the ferroportin-hepcidin complex has led to a critical review on the treatment of anemia and anemia of inflammation (AI). Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively regulated by hepcidin, a ...
Antimo Cutone +6 more
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Iron homeostasis and eye disease [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009 Iron is necessary for life, but excess iron can be toxic to tissues. Iron is thought to damage tissues primarily by generating oxygen free radicals through the Fenton reaction.We present an overview of the evidence supporting iron's potential contribution to a broad range of eye disease using an anatomical approach.Iron can be visualized in the cornea ...
Allison, Loh +2 more
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Iron homeostasis: An anthropocentric perspective [PDF]
Journal of Biological Chemistry, 2017 The regulation of iron metabolism in biological systems centers on providing adequate iron for cellular function while limiting iron toxicity. Because mammals cannot excrete iron, mechanisms have evolved to control iron acquisition, storage, and distribution at both systemic and cellular levels.
Coffey, Richard, Ganz, Tomas
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Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. [PDF]
, 2019 Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis. Its expression is regulated by the bone morphogenetic protein 6 (BMP6)/SMAD1/5/8 pathway and by the proinflammatory cytokine interleukin 6 (IL6).
Anower-E-Khuda, Ferdous +8 more
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Quantitative RNA-seq Analysis Unveils Osmotic and Thermal Adaptation Mechanisms Relevant for Ectoine Production in Chromohalobacter salexigens [PDF]
, 2018 Quantitative RNA sequencing (RNA-seq) and the complementary phenotypic assays were implemented to investigate the transcriptional responses of Chromohalobacter salexigens to osmotic and heat stress.
Carmen Vargas +6 more
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Research progress of the role of iron homeostasis in ferroptosis in Alzheimer’s disease
Guoji laonian yixue zazhiFerroptosis is a distinct type of cellular demise frequently identified in the cerebral tissues of individuals afflicted with Alzheimer’s disease (AD).
Luo Chenliang +3 more
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FIT-Binding Proteins and Their Functions in the Regulation of Fe Homeostasis
Frontiers in Plant Science, 2019 Iron, as an essential micronutrient, is required by all living organisms. In plants, the deficiency and excess of iron will impair their growth and development.
Huilan Wu +2 more
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The essential roles of metal ions in insect homeostasis and physiology [PDF]
, 2017 Metal ions play distinct roles in living organisms, including insects. Some, like sodium and potassium, are central players in osmoregulation and ‘blood and guts’ transport physiology, and have been implicated in cold adaptation.
Dow, Julian A.T.
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