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Influence of Iron on Bone Homeostasis [PDF]
Pharmaceuticals, 2018 Bone homeostasis is a complex process, wherein osteoclasts resorb bone and osteoblasts produce new bone tissue. For the maintenance of skeletal integrity, this sequence has to be tightly regulated and orchestrated.
Enikő Balogh +2 more
exaly +5 more sources
Down the Iron Path: Mitochondrial Iron Homeostasis and Beyond
Cells, 2021 Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent. Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate these cofactors along with iron ions into mitochondrial proteins that support ...
Oleh Khalimonchuk +2 more
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Brain Iron Homeostasis and Mental Disorders
Antioxidants, 2023 Iron plays an essential role in various physiological processes. A disruption in iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer.
Qiong Wu +4 more
doaj +2 more sources
Iron homeostasis at the interface of nutrition, infection, and iron supplementation [PDF]
Frontiers in NutritionIron is an essential micronutrient that plays a central role in oxygen transport, mitochondrial respiration, DNA synthesis, immune regulation, and numerous enzymatic reactions.
Özge Mert, Seray Saday, Aybala Temel
doaj +2 more sources
Iron Homeostasis in the Lungs—A Balance Between Health and Disease
Pharmaceuticals, 2019 A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is evident in the lung, where both systems must be properly controlled to maintain lung function.
Martina Muckenthaler +2 more
exaly +3 more sources
Role of Dietary Flavonoids in Iron Homeostasis
Pharmaceuticals, 2019 Balancing systemic iron levels within narrow limits is critical for human health, as both iron deficiency and overload lead to serious disorders. There are no known physiologically controlled pathways to eliminate iron from the body and therefore iron ...
Marija Lesjak, Surjit K S Srai
exaly +3 more sources
Mammalian SLC39A13 Promotes ER/Golgi Iron Transport and Iron Homeostasis in Multiple Compartments
Nature CommunicationsIron is a potent biochemical, and accurate homeostatic control is orchestrated by a network of interacting players at multiple levels. Although our understanding of organismal iron homeostasis has advanced, intracellular iron homeostasis is poorly ...
Kuanyu Li, Fei Sun, Bing Zhou
exaly +2 more sources
Frontiers in Plant Science, 2023 Cellular homeostasis of the micronutrient iron is highly regulated in plants and responsive to nutrition, stress, and developmental signals. Genes for iron management encode metal and other transporters, enzymes synthesizing chelators and reducing ...
Hans-Jörg Mai +3 more
doaj +1 more source
Minireview: Chromatin-based regulation of iron homeostasis in plants
Frontiers in Plant Science, 2022 Plants utilize delicate mechanisms to effectively respond to changes in the availability of nutrients such as iron. The responses to iron status involve controlling gene expression at multiple levels.
Justin Su +4 more
doaj +1 more source
Non-invasive assessment of normal and impaired iron homeostasis in the brain
Nature Communications, 2023 Strict iron regulation is essential for normal brain function. The iron homeostasis, determined by the milieu of available iron compounds, is impaired in aging, neurodegenerative diseases and cancer.
Shir Filo +9 more
doaj +1 more source