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Down the Iron Path: Mitochondrial Iron Homeostasis and Beyond
Cells, 2021 Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent. Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate these cofactors along with iron ions into mitochondrial proteins that support ...
Jonathan V. Dietz +2 more
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Antioxidants, 2023 Iron is essential for life. Many enzymes require iron for appropriate function. However, dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species (ROS) via the Fenton reaction and causes devastating effects on cells ...
Jaewang Lee, Dong-Hoon Hyun
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Iron Homeostasis in the Lungs—A Balance between Health and Disease
Pharmaceuticals, 2019 A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is evident in the lung, where both systems must be properly controlled to maintain lung function.
Joana Neves +3 more
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Frontiers in Plant Science, 2023 Cellular homeostasis of the micronutrient iron is highly regulated in plants and responsive to nutrition, stress, and developmental signals. Genes for iron management encode metal and other transporters, enzymes synthesizing chelators and reducing ...
Hans-Jörg Mai +3 more
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Minireview: Chromatin-based regulation of iron homeostasis in plants
Frontiers in Plant Science, 2022 Plants utilize delicate mechanisms to effectively respond to changes in the availability of nutrients such as iron. The responses to iron status involve controlling gene expression at multiple levels.
Justin Su +4 more
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Non-invasive assessment of normal and impaired iron homeostasis in the brain
Nature Communications, 2023 Strict iron regulation is essential for normal brain function. The iron homeostasis, determined by the milieu of available iron compounds, is impaired in aging, neurodegenerative diseases and cancer.
Shir Filo +9 more
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Advanced Science, 2023 Doxorubicin (DOX)‐induced cardiotoxicity (DoIC) is a major side effect for cancer patients. Recently, ferroptosis, triggered by iron overload, is demonstrated to play a role in DoIC.
Jianan Pan +11 more
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Interpreting Iron Homeostasis in Congenital and Acquired Disorders
Pharmaceuticals, 2023 Mammalian cells require iron to satisfy their metabolic needs and to accomplish specialized functions, such as hematopoiesis, mitochondrial biogenesis, energy metabolism, or oxygen transport.
Natalia Scaramellini +5 more
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Host and microbiota derived extracellular vesicles: Crucial players in iron homeostasis
Frontiers in Medicine, 2022 Iron is a double-edged sword. It is vital for all that’s living, yet its deficiency or overload can be fatal. In humans, iron homeostasis is tightly regulated at both cellular and systemic levels.
Yasmeen Daou +8 more
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Brain Iron Homeostasis and Mental Disorders
Antioxidants, 2023 Iron plays an essential role in various physiological processes. A disruption in iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer.
Qiong Wu +4 more
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