Results 1 to 10 of about 1,016,828 (293)

Iron overload induces ROS-mediated neural stem/progenitor cells apoptosis via mTOR pathway [PDF]

BMC Neuroscience
Intracerebral hemorrhage (ICH) is a health challenge resulting in death or disability. Iron overload has been identified as one of post-ICH damaging factors.
Fengchun Zhao, Wei Quan, Qian Zhang, Yi Yin, Yibin Jiang, Xuyang Zhang, Huanhuan Li, Chao Zhang, Lan Li, Shengli Hu, Fei Li, Rong Hu   +11 more
doaj   +2 more sources

Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice

Journal of Advanced Research
Introduction: Iron overload disrupts gut microbiota and induces ferroptosis, contributing to colitis. However, whether gut microbiota directly drives iron overload-induced colitis and its underlying mechanism remain unclear.
Ke Gu, Aimin Wu, Chen Liu, Bing Yu, Jun He, Xin Lai, Junzhou Chen, Yuheng Luo, Hui Yan, Ping Zheng, Junqiu Luo, Junning Pu, Quyuan Wang, Huifen Wang, Daiwen Chen   +14 more
doaj   +3 more sources

Iron overload disrupts bone homeostasis via dual pathways: inducing ferroptosis of preosteoblastic cells and shaping a proinflammatory immune milieu [PDF]

Frontiers in Pharmacology
Iron overload is regarded as an independent risk factor for osteoporosis, yet the underlying molecular mechanisms remain incompletely understood. In this study, we systematically investigated the impact of iron overload on bone homeostasis using a ...
Yu Pan, Yu Pan, Renfeng Zhao, Chengdong Zhang, Feng Shi, Hui Wu, Dongqin Xiao, Dongqin Xiao   +7 more
doaj   +2 more sources

Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis

Case Reports in Gastroenterology, 2015
Disturbances in iron metabolism can be genetic or acquired and accordingly manifest as primary or secondary iron overload state. Organ damage may result from iron overload and manifest clinically as cirrhosis, diabetes mellitus, arthritis, endocrine ...
Jasbir Makker, Ahmad Hanif, Bharat Bajantri, Sridhar Chilimuri   +3 more
doaj   +3 more sources

Nrf2 activators for the treatment of rare iron overload diseases: From bench to bedside

Redox Biology
Iron overload and related oxidative damage are seen in many rare diseases, due to mutation of iron homeostasis-related genes. As a core regulator on cellular antioxidant reaction, Nrf2 can also decrease systemic and cellular iron levels by regulating ...
Yimin Dong, Meng Zheng, Weizhong Ding, Hanfeng Guan, Jun Xiao, Feng Li   +5 more
doaj   +3 more sources

The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading

Insights into Imaging, 2022
Objectives Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients.
Basant Mohamed Raief Mosaad, Ahmed Samir Ibrahim, Mohamed G. Mansour, Mohsen Saleh ElAlfy, Fatma Soliman Elsayed Ebeid, Emad H. Abdeldayem   +5 more
doaj   +1 more source

Iron Overload in a Patient with Non-Transfusion-Dependent Hemoglobin H Disease and Borderline Serum Ferritin: Can We Rely on Serum Ferritin for Monitoring in This Group of Patients?

Case Reports in Oncology, 2020
Secondary iron overload is a common complication in the context of hematological diseases, as iron accumulates due to different mechanisms including chronic transfusion, increased gastrointestinal absorption, chronic hemolysis and underlying genetic ...
Mohammad Ali, Mohamed A. Yassin, Maya Aldeeb   +2 more
doaj   +1 more source

Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundSex‐related differences in cardiac function and iron metabolism exist in humans and experimental animals. Male patients and preclinical animal models are more susceptible to cardiomyopathies and heart failure.
Subhash K. Das, Vaibhav B. Patel, Ratnadeep Basu, Wang Wang, Jessica DesAulniers, Zamaneh Kassiri, Gavin Y. Oudit   +6 more
doaj   +1 more source

Extensive iron overload in bone marrow: A cause of pancytopenia in a thalassemia major patient – A case report

Asian Journal of Transfusion Science, 2020
Iron overload-associated organ damage in transfusion-dependent anemias is a well-known phenomenon. Here, we discuss a case of 28-year-old, poorly chelated thalassemia major patient, whose blood workup revealed pancytopenia and moderately raised serum ...
Maria Ali, Sidra Asad Ali, Huma Mansoori
doaj   +1 more source

Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow

Brazilian Journal of Medical and Biological Research, 2017
Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with
J.C. Shen, Y.C. Zhang, M.F. Zhao
doaj   +1 more source