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Iron overload disorders

Hepatology Communications, 2022
Iron overload disorders represent a variety of conditions that lead to increased total body iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron saturation can be commonly encountered in the evaluation of elevated liver ...
Christine C. Hsu, Nizar H. Senussi, Kleber Y. Fertrin, Kris V. Kowdley   +3 more
doaj   +4 more sources

Nrf2 activators for the treatment of rare iron overload diseases: From bench to bedside

Redox Biology
Iron overload and related oxidative damage are seen in many rare diseases, due to mutation of iron homeostasis-related genes. As a core regulator on cellular antioxidant reaction, Nrf2 can also decrease systemic and cellular iron levels by regulating ...
Yimin Dong, Meng Zheng, Weizhong Ding, Hanfeng Guan, Jun Xiao, Feng Li   +5 more
doaj   +3 more sources

The role of MRI-R2* in the detection of subclinical pancreatic iron loading among transfusion-dependent sickle cell disease patients and correlation with hepatic and cardiac iron loading

Insights into Imaging, 2022
Objectives Pancreatic reserve could be preserved by early assessment of pancreatic iron overload among transfusion-dependent sickle cell disease (SCD) patients.
Basant Mohamed Raief Mosaad, Ahmed Samir Ibrahim, Mohamed G. Mansour, Mohsen Saleh ElAlfy, Fatma Soliman Elsayed Ebeid, Emad H. Abdeldayem   +5 more
doaj   +1 more source

Evaluation of iron overload [PDF]

British Journal of Haematology, 2004
exaly   +4 more sources

Iron Overload in a Patient with Non-Transfusion-Dependent Hemoglobin H Disease and Borderline Serum Ferritin: Can We Rely on Serum Ferritin for Monitoring in This Group of Patients?

Case Reports in Oncology, 2020
Secondary iron overload is a common complication in the context of hematological diseases, as iron accumulates due to different mechanisms including chronic transfusion, increased gastrointestinal absorption, chronic hemolysis and underlying genetic ...
Mohammad Ali, Mohamed A. Yassin, Maya Aldeeb   +2 more
doaj   +1 more source

Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundSex‐related differences in cardiac function and iron metabolism exist in humans and experimental animals. Male patients and preclinical animal models are more susceptible to cardiomyopathies and heart failure.
Subhash K. Das, Vaibhav B. Patel, Ratnadeep Basu, Wang Wang, Jessica DesAulniers, Zamaneh Kassiri, Gavin Y. Oudit   +6 more
doaj   +1 more source

Extensive iron overload in bone marrow: A cause of pancytopenia in a thalassemia major patient – A case report

Asian Journal of Transfusion Science, 2020
Iron overload-associated organ damage in transfusion-dependent anemias is a well-known phenomenon. Here, we discuss a case of 28-year-old, poorly chelated thalassemia major patient, whose blood workup revealed pancytopenia and moderately raised serum ...
Maria Ali, Sidra Asad Ali, Huma Mansoori
doaj   +1 more source

Iron-overload myopathy [PDF]

International Journal of Hematology, 2011
A 66-year-old male patient presented with a 4-month history of progressive muscle weakness. Twelve years prior to presentation he was evaluated for fatigue, weight loss, new-onset diabetes and elevated liver enzymes and was diagnosed with hereditary hemochromatosis, homozygous for the C282Y mutation in the HFE gene.
Javier, Munoz, Natalia, Ferrari, Philip, Kuriakose   +2 more
openaire   +2 more sources

Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow

Brazilian Journal of Medical and Biological Research, 2017
Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with
J.C. Shen, Y.C. Zhang, M.F. Zhao
doaj   +1 more source

Assessment of hepatic and cardiac iron overload in thalassemia patients by magnetic resonance imaging: Our experience in Alexandria University

The Egyptian Journal of Radiology and Nuclear Medicine, 2018
Aim of the study: The aim of this study was to assess the utility of MRI as a non-invasive technique for grading of the hepatic and cardiac iron overload in Thalassemia patients in a cohort of patients in Alexandria, Egypt.
Sara K. Elfawal, Doaa M. Emara, Ahmed A. Shehata   +2 more
doaj   +1 more source